On the distinction of empathic and vicarious emotions

In the introduction to the special issue “The Neural Underpinnings of Vicarious Experience” the editors state that one “may feel embarrassed when witnessing another making a social faux pas”. In our commentary we address this statement and ask whether this example introduces a vicarious or an empathic form of embarrassment. We elaborate commonalities and differences between these two forms of emotional experiences and discuss their underlying mechanisms. We suggest that both, vicarious and empathic emotions, originate from the simulation processes mirroring and mentalizing that depend on anchoring and adjustment. We claim the term “empathic emotion” to be reserved exclusively for incidents where perceivers and social targets have shared affective experience, whereas “vicarious emotion” offers a wider scope and also includes non-shared affective experiences. Both are supposed to be highly functional in social interactions

from a better etiological understanding, through valid diagnosis, to more effective health care

Background Autism Spectrum Disorder (ASD) is a severe, lifelong neurodevelopmental disorder with early onset that places a heavy burden on affected individuals and their families. Due to the need for highly specialized health, educational and vocational services, ASD is a cost- intensive disorder, and strain on health care systems increases with increasing age of the affected individual. Methods The ASD-Net will study Germany’s largest cohort of patients with ASD over the lifespan. By combining methodological expertise from all levels of clinical research, the ASD-Net will follow a translational approach necessary to identify neurobiological pathways of different phenotypes and their appropriate identification and treatment. The work of the ASD-Net will be organized into three clusters concentrating on diagnostics, therapy and health economics. In the diagnostic cluster, data from a large, well-characterized sample (N = 2568) will be analyzed to improve the efficiency of diagnostic procedures. Pattern classification methods (machine learning) will be used to identify algorithms for screening purposes. In a second step, the developed algorithm will be tested in an independent sample. In the therapy cluster, we will unravel how an ASD-specific social skills training with concomitant oxytocin administration can modulate behavior through neurobiological pathways. For the first time, we will characterize long-term effects of a social skills training combined with oxytocin treatment on behavioral and neurobiological phenotypes. Also acute effects of oxytocin will be investigated to delineate general and specific effects of additional oxytocin treatment in order to develop biologically plausible models for symptoms and successful therapeutic interventions in ASD. Finally, in the health economics cluster, we will assess service utilization and ASD-related costs in order to identify potential needs and cost savings specifically tailored to Germany. The ASD-Net has been established as part of the German Research Network for Mental Disorders, funded by the BMBF (German Federal Ministry of Education and Research). Discussion The highly integrated structure of the ASD-Net guarantees sustained collaboration of clinicians and researchers to alleviate individual distress, harm, and social disability of patients with ASD and reduce costs to the German health care system. Trial registration Both clinical trials of the ASD- Net are registered in the German Clinical Trials Register: DRKS00008952 (registered on August 4, 2015) and DRKS00010053 (registered on April 8, 2016)

Handedness is related to neural mechanisms underlying hemispheric lateralization of face processing

While the right-hemispheric lateralization of the face perception network is well established, recent evidence suggests that handedness affects the cerebral lateralization of face processing at the hierarchical level of the fusiform face area (FFA). However, the neural mechanisms underlying differential hemispheric lateralization of face perception in right- and left-handers are largely unknown. Using dynamic causal modeling (DCM) for fMRI, we aimed to unravel the putative processes that mediate handedness-related differences by investigating the effective connectivity in the bilateral core face perception network. Our results reveal an enhanced recruitment of the left FFA in left-handers compared to right-handers, as evidenced by more pronounced face-specific modulatory influences on both intra- and interhemispheric connections. As structural and physiological correlates of handedness-related differences in face processing, right- and left-handers varied with regard to their gray matter volume in the left fusiform gyrus and their pupil responses to face stimuli. Overall, these results describe how handedness is related to the lateralization of the core face perception network, and point to different neural mechanisms underlying face processing in right- and left-handers. In a wider context, this demonstrates the entanglement of structurally and functionally remote brain networks, suggesting a broader underlying process regulating brain lateralization

A Psychological Perspective on Vicarious Embarrassment and Shame in the Context of Cringe Humor

Cringe humor combines the seemingly opposite emotional experiences of amusement and embarrassment due to others’ transgressions of norms. Psychological theories and empirical studies on these emotional reactions in response to others’ transgressions of social norms have mostly focused on embarrassment and shame. Here, we build on this literature, aiming to present a novel perspective on cringe humor. To do so, we introduce the psychological literature on embarrassment and shame, as well as the processes involved that allow humans to also experience these emotions on behalf of others, and draw theoretical links to cringe comedy. We then systematically disentangle contexts in which audiences experience vicarious embarrassment, and structure our argument based on the ongoing processes and consequences of the observed transgressions of norms based on the constituting dimensions of awareness and intentionality of the normative transgression by the social target. We describe how the behavioral expressions of the target along with the social distance and the current motivations of the audience shape the emotional experience and negotiation of social norms, specifically in response to intentional normative transgressions. While this perspective makes it evident that cringe humor is closely linked to the debate around social normative standards between the actor/actress and the audience, we conclude that the different manifestations and specific situational characteristics have fundamentally different consequences for the affirmation or renegotiation of social normative standards

A Psychological Perspective on Vicarious Embarrassment and Shame in the Context of Cringe Humor

Cringe humor combines the seemingly opposite emotional experiences of amusement and embarrassment due to others’ transgressions of norms. Psychological theories and empirical studies on these emotional reactions in response to others’ transgressions of social norms have mostly focused on embarrassment and shame. Here, we build on this literature, aiming to present a novel perspective on cringe humor. To do so, we introduce the psychological literature on embarrassment and shame, as well as the processes involved that allow humans to also experience these emotions on behalf of others, and draw theoretical links to cringe comedy. We then systematically disentangle contexts in which audiences experience vicarious embarrassment, and structure our argument based on the ongoing processes and consequences of the observed transgressions of norms based on the constituting dimensions of awareness and intentionality of the normative transgression by the social target. We describe how the behavioral expressions of the target along with the social distance and the current motivations of the audience shape the emotional experience and negotiation of social norms, specifically in response to intentional normative transgressions. While this perspective makes it evident that cringe humor is closely linked to the debate around social normative standards between the actor/actress and the audience, we conclude that the different manifestations and specific situational characteristics have fundamentally different consequences for the affirmation or renegotiation of social normative standards

Mentalizing and the Role of the Posterior Superior Temporal Sulcus in Sharing Others' Embarrassment

The experience of embarrassment provides a highly salient cue for the human moral apparatus. Interestingly, people also experience embarrassment on behalf of others' inappropriate conditions. The perceiver's embarrassment often lacks an equivalent expression of embarrassment in the social counterpart. The present study examines this phenomenon and distinguishes neural circuits involved in embarrassment with and embarrassment for another person's mishaps. Using functional magnetic resonance imaging, we show that the embarrassment on behalf of others engages the temporal pole and the medial prefrontal cortex, central structures of the mentalizing network, together with the anterior insula and anterior cingulate cortex. In contrast, sharing others' embarrassment additionally stimulated the posterior superior temporal sulcus (STS), which exhibited increased functional integration with inferior parietal and insular cortex areas. These findings characterize common neural circuits involved in the embodied representation of embarrassment and further unravel the unique role of the posterior STS in sharing others' affective state

Altered physiological, affective, and functional connectivity responses to acute stress in patients with alcohol use disorder

The present study examined physiological and affective responses to stress and functional connectivity in Alcohol Use Disorder

Mechanisms of hemispheric lateralization: Asymmetric interhemispheric recruitment in the face perception network

Perceiving human faces constitutes a fundamental ability of the human mind, integrating a wealth of information essential for social interactions in everyday life. Neuroimaging studies have unveiled a distributed neural network consisting of multiple brain regions in both hemispheres. Whereas the individual regions in the face perception network and the right-hemispheric dominance for face processing have been subject to intensive research, the functional integration among these regions and hemispheres has received considerably less attention. Using dynamic causal modeling (DCM) for fMRI, we analyzed the effective connectivity between the core regions in the face perception network of healthy humans to unveil the mechanisms underlying both intra- and interhemispheric integration. Our results suggest that the right-hemispheric lateralization of the network is due to an asymmetric face-specific interhemispheric recruitment at an early processing stage - that is, at the level of the occipital face area (OFA) but not the fusiform face area (FFA). As a structural correlate, we found that OFA gray matter volume was correlated with this asymmetric interhemispheric recruitment. Furthermore, exploratory analyses revealed that interhemispheric connection asymmetries were correlated with the strength of pupil constriction in response to faces, a measure with potential sensitivity to holistic (as opposed to feature-based) processing of faces. Overall, our findings thus provide a mechanistic description for lateralized processes in the core face perception network, point to a decisive role of interhemispheric integration at an early stage of face processing among bilateral OFA, and tentatively indicate a relation to individual variability in processing strategies for faces. These findings provide a promising avenue for systematic investigations of the potential role of interhemispheric integration in future studies