3 research outputs found
Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy
Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or
lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular
damage can be observed. This study evaluated the possible relationship between structure (spectral
domain–optical coherence tomography) and function (Rarebit visual field test) in patients with type 1
diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular
visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of
the macula of diabetic patients (Rs = 0.65, p < 0.001). In multivariable logistic regression analysis, GCL
thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1–2.1). Early
DR seems to include a neurodegenerative component