A Study on Biocompatibility of Three Endodontic Sealers: Intensity and Duration of Tissue Irritation

Introduction: Several studies have evaluated the inflammatory reaction triggered by Epiphany (EPH), a contemporary endodontic sealer. However, they used conventional parameters, which need additional analysis to better understand the reactions induced by this sealer compared to other traditional sealers. Methods and Materials: The intensity and time span of tissue irritations for three endodontic sealers were assessed by inflammatory reactions, fibrous capsule measurement and mast cell counts. Tubes containing freshly mixed EPH, AH plus (AHP) and Endofill (ENF) were subcutaneously implanted into the backs of 28 Wistar rats. The side wall of the tube was used as the control. At 14, 21, 42 and 60 days, the connective tissue surrounding the implants (n=7) was stainedfor histopathological analysis. The Friedman test was applied to compare the results. The level of significance was set at 0.05. Results: At days 14 and 21, a significant difference among the groups was observed, with the ENF showing the worst tissue response (P<0.001). ENF remained the most aggressive sealer at 42 and 60 days, compared with EPH (P<0.05). No differences were found for the fibrous capsule thicknesses among the groups in each period. The number of mast cells per field did not show difference among the sealers at 21 and 60 days. Conclusions: EPH and AHP elicited similar patterns of irritation, as demonstrated by the inflammatory scores and fibrous capsule thicknesses. ENF caused the highest degree of tissue damage. The increase in mast cell counts observed during the early and late periods shows the possibility of late hypersensitivity to the test materials

Effects of titanium surface anodization with CaP incorporation on human osteoblastic response

In this study we investigated whether anodization with calcium phosphate (CaP) incorporation (Vulcano®) enhances growth factors secretion, osteoblast-specific gene expression, and cell viability, when compared to acid etched surfaces (Porous®) and machined surfaces (Screw®) after 3 and 7 days. Results showed significant cell viability for Porous and Vulcano at day 7, when compared with Screw (p=0.005). At the same time point, significant differences regarding runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and bone sialoprotein (BSP) expression were found for all surfaces (p0.05). Although no significant correlation was found for growth factors secretion and Runx2 expression, a significant positive correlation between this gene and ALP/BSP expression showed that their strong association is independent on the type of surface. The incorporation of CaP affected the biological parameters evaluated similar to surfaces just acid etched. The results presented here support the observations that roughness also may play an important role in determining cell response

DERMATOLOGICAL MANIFESTATIONS OF POLYCYSTIC OVARY SYNDROME

Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in women of reproductive age, characterized by hormonal imbalances, ovulatory dysfunction, and multiple ovarian cysts. In addition to gynecological symptoms, PCOS can also present significant dermatological manifestations, which affect not only the appearance, but also the quality of life of patients. These manifestations include hirsutism, acne, alopecia and skin pigmentation, among others. Understanding the relationship between PCOS and its dermatological manifestations is crucial for early diagnosis and adequate management of the condition. Objective: To analyze and synthesize recent scientific literature on dermatological manifestations associated with polycystic ovary syndrome, highlighting its prevalence, clinical characteristics and therapeutic approaches. Methodology: The systematic review was conducted in accordance with PRISMA guidelines. Searches were carried out in the PubMed, Scielo and Web of Science databases, limited to articles published in the last 10 years, using the descriptors "polycystic ovary syndrome", "dermatological manifestations", "hirsutism", "acne", "alopecia" . The inclusion criteria were original human studies, in English or Portuguese, that investigated dermatological manifestations in patients with PCOS. Exclusion criteria were animal studies, case reports and narrative reviews. Results: The analysis of the selected studies revealed a high prevalence of dermatological manifestations in patients with PCOS, with hirsutism and acne being the most common. Factors such as insulin resistance and hyperandrogenism play an important role in the development of these manifestations. Several therapeutic approaches, including hormonal agents and insulin modulators, have been investigated for the management of these symptoms. Conclusion: This review highlights the importance of identifying and adequately treating dermatological manifestations in PCOS, aiming not only to improve aesthetics, but also the quality of life and overall health of patients. Early recognition of these symptoms can lead to effective interventions and better long-term clinical outcomes.Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions in women of reproductive age, characterized by hormonal imbalances, ovulatory dysfunction, and multiple ovarian cysts. In addition to gynecological symptoms, PCOS can also present significant dermatological manifestations, which affect not only the appearance, but also the quality of life of patients. These manifestations include hirsutism, acne, alopecia and skin pigmentation, among others. Understanding the relationship between PCOS and its dermatological manifestations is crucial for early diagnosis and adequate management of the condition. Objective: To analyze and synthesize recent scientific literature on dermatological manifestations associated with polycystic ovary syndrome, highlighting its prevalence, clinical characteristics and therapeutic approaches. Methodology: The systematic review was conducted in accordance with PRISMA guidelines. Searches were carried out in the PubMed, Scielo and Web of Science databases, limited to articles published in the last 10 years, using the descriptors "polycystic ovary syndrome", "dermatological manifestations", "hirsutism", "acne", "alopecia" . The inclusion criteria were original human studies, in English or Portuguese, that investigated dermatological manifestations in patients with PCOS. Exclusion criteria were animal studies, case reports and narrative reviews. Results: The analysis of the selected studies revealed a high prevalence of dermatological manifestations in patients with PCOS, with hirsutism and acne being the most common. Factors such as insulin resistance and hyperandrogenism play an important role in the development of these manifestations. Several therapeutic approaches, including hormonal agents and insulin modulators, have been investigated for the management of these symptoms. Conclusion: This review highlights the importance of identifying and adequately treating dermatological manifestations in PCOS, aiming not only to improve aesthetics, but also the quality of life and overall health of patients. Early recognition of these symptoms can lead to effective interventions and better long-term clinical outcomes

ASSESSMENT AND SURGICAL MANAGEMENT OF APPENDICITIS IN PEDIATRICS

Acute appendicitis is one of the most common surgical emergencies in childhood, requiring rapid assessment and intervention. The clinical and radiological characteristics of this condition may vary in children, presenting significant diagnostic challenges. Surgical management is essential to avoid serious complications, such as perforation and peritonitis. Considering the importance of an early and precise approach, the evaluation and surgical management of appendicitis in pediatrics have been the subject of studies and systematic reviews to optimize clinical practice. Objective: To analyze and synthesize recent studies on the evaluation and surgical management of appendicitis in children, aiming to identify the best diagnostic and therapeutic practices. Methodology: The review was carried out in accordance with PRISMA guidelines. The PubMed, Scielo and Web of Science databases were searched for articles published in the last 10 years. The descriptors used included "pediatric appendicitis", "diagnosis", "surgery", "management" and "evaluation". The inclusion criteria were original studies focusing on clinical evaluation, imaging diagnosis and surgical management in pediatric patients with acute appendicitis. Exclusion criteria were studies in languages other than English, Portuguese or Spanish, case reports and narrative reviews. Results: The results highlighted the importance of careful clinical evaluation, together with the use of imaging tests, such as ultrasound and computed tomography, in the diagnostic approach to appendicitis in children. In addition, several surgical strategies were discussed, including laparoscopy, and the role of pre- and postoperative antibiotic therapy. Factors such as age, clinical presentation and time elapsed since the onset of symptoms were considered when making surgical decisions. Conclusion: The systematic review highlights the importance of a multidisciplinary and individualized approach in the evaluation and surgical management of appendicitis in pediatrics. The evidence gathered provides support to improve clinical practices, aiming for an effective and safe approach in this specific context.Acute appendicitis is one of the most common surgical emergencies in childhood, requiring rapid assessment and intervention. The clinical and radiological characteristics of this condition may vary in children, presenting significant diagnostic challenges. Surgical management is essential to avoid serious complications, such as perforation and peritonitis. Considering the importance of an early and precise approach, the evaluation and surgical management of appendicitis in pediatrics have been the subject of studies and systematic reviews to optimize clinical practice. Objective: To analyze and synthesize recent studies on the evaluation and surgical management of appendicitis in children, aiming to identify the best diagnostic and therapeutic practices. Methodology: The review was carried out in accordance with PRISMA guidelines. The PubMed, Scielo and Web of Science databases were searched for articles published in the last 10 years. The descriptors used included "pediatric appendicitis", "diagnosis", "surgery", "management" and "evaluation". The inclusion criteria were original studies focusing on clinical evaluation, imaging diagnosis and surgical management in pediatric patients with acute appendicitis. Exclusion criteria were studies in languages other than English, Portuguese or Spanish, case reports and narrative reviews. Results: The results highlighted the importance of careful clinical evaluation, together with the use of imaging tests, such as ultrasound and computed tomography, in the diagnostic approach to appendicitis in children. In addition, several surgical strategies were discussed, including laparoscopy, and the role of pre- and postoperative antibiotic therapy. Factors such as age, clinical presentation and time elapsed since the onset of symptoms were considered when making surgical decisions. Conclusion: The systematic review highlights the importance of a multidisciplinary and individualized approach in the evaluation and surgical management of appendicitis in pediatrics. The evidence gathered provides support to improve clinical practices, aiming for an effective and safe approach in this specific context

Avaliação do selamento apical dos cimentos endorez e endomethasone.

Avaliação do selamento apical dos cimentos endorez e endomethasone

Análise radiográfica da espessura dental do 1° molar superior após preparo anticurvatura.

Análise radiográfica da espessura dental do 1° molar superior após preparo anticurvatura

Radiographic and histomorphometric analysis of bone healing using autogenous graft associated with platelet-rich plasma obtained by 2 different methods

The aim of this study was to conduct radiographic and histomorphometric analysis of bone healing in the calvaria of rabbits, using an autogenous graft associated with PRP obtained by 2 different methods. Thirty rabbits were divided into control and experimental groups. Lesions were produced in the calvaria and filled with autogenous graft ( control) or autogenous graft and PRP obtained by the Anitua or modified Sonnleitner methods. The animals were humanely killed 15 days after surgery and the calvarias were radiographed. The radiographs were digitized to assess the radiographic density. By histologic images of the lesion, the bone matrix was quantified. There were no significant differences in the radiographic density and the bone matrix area between the groups. The association of PRP with autogenous bone did not improve the healing process, irrespective of the method used early during healing

Avaliação histomorfométrica computadorizada do remanescente dentinário da raiz mésio vestibular do primeiro molar inferior, após o preparo com brocas de gates glidden.

Avaliação histomorfométrica computadorizada do remanescente dentinário da raiz mésio vestibular do primeiro molar inferior, após o preparo com brocas de gates glidden