Using Windmill Expansion for Document Retrieval

SEMIOTIKS aims to utilise online information to support the crucial decision–making of those military and civilian agencies involved in the humanitarian removal of landmines in areas of conflict throughout the world. An analysis of the type of information required for such a task has given rise to four main areas of research: information retrieval, document annotation, summarisation and visualisation. The first stage of the research has focused on information retrieval, and a new algorithm, “Windmill Expansion” (WE) has been proposed to do this. The algorithm uses retrieval feedback techniques for automated query expansion in order to improve the effectiveness of information retrieval. WE is based on the extraction of human–generated written phases for automated query expansion. Top and Second Level expansion terms have been generated and their usefulness evaluated. The evaluation has concentrated on measuring the degree of overlap between the retrieved URLs. The less the overlap, the more useful the information provided. The Top Level expansion terms were found to provide 90% of useful URLs, and the Second Level 83% of useful URLs. Although there was a decline of useful URLs from the Top Level to the Second Level, the quantity of relevant information retrieved has increased. The originality of SEMIOTIKS lies in its use of the WE algorithm to help non–domain specific experts automatically explore domain words for relevant and precise information retrieval

A Behavioral Analysis of Passphrase Design and Effectiveness

Although the use of multiple methods of user authentication for IT system increases security, passwords are often the only credential required for access. Consequently, the challenge is to discover ways to improve password strength without impairing usability. Longer pass “phrases” have received increased attention as a solution to this challenge because they are potentially more resistant to attacks yet are easy to remember. Recent evidence, however, suggests that passphrases increase the likelihood of typographical errors resulting in login failures and negative user perceptions. This paper presents experimental results that demonstrate well-designed passphrases do not increase login failures and, thereby, generate positive user perceptions. Implications are drawn to help IT managers develop effective IT security policies in utilizing passphrases to improve authentication and to assist researchers in identifying avenues for future research

Extensive Particle Identification with TPC and TOF at the STAR Experiment

Particle identification (PID) capabilities are studied by using the Time Projection Chamber (TPC) and a Time-Of-Flight (TOF) detector together at STAR. The identification capability of charged hadrons is greatly extended compared with that achieved by TPC and TOF separately. Particle spectra from p+p, d+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV and Au+Au collisions at $\sqrt{s_{_{NN}}}=62.4$ GeV are used to develop the methods. The transverse momentum ($p_T$) ranges of $\pi$, and $p(\bar{p})$ identification are from $\sim0.3$ GeV/$c$ to $\sim10$ GeV/$c$. The high $p_T$ reach is limited by statistics in current data sets. An important conceptual advance was developed to identify electrons by using a combination of dE/dx in TPC and velocity information from the TOF detectors, which is important for future low-mass dilepton program at STAR.Comment: 19 pages, 22 figures, 3 tables, submitted to NIM

Impact of raw materials on sialyation for a therapeutic protein

Total sialic acid content (TSAC) is a critical product quality attribute (CQA) for a therapeutic protein. Previous studies and results have suggested lot-to-lot variability of raw material, media powder and feed, have potential effects on total sialyation acid content (TSAC) at cell culture fluid (CCF) and harvested cell culture fluid (HCCF). Through searching literature, we found that potential components in media powder and feed such trace metal and vitamins can greatly modulate the sialyation acid level in vivo or in vitro. For instance, the sialic acid content was simultaneously increased in glycopeptides as well as gangliosides under lithium treatment1. Moreover, supplementation of vitamin A, B, C and E were found significant correlation with sialic acid levels in variety of organisms2, 3, & 4. Therefore, an investigation was performed to further examine the relationship between TSAC level and suggested component Multivariate analysis was performed to identify metal and vitamin candidates that potentially have positive or negative effect on sialyation acid level. Top candidates will be selected and experiments will then be performed to carefully evaluate their impacts. We thereby aim to establish the efficient platform to screen for critical regulators of raw materials on TSAC level. This study will provide the insight of understanding better control of product quality and establishes a methodology for identifying the rooting causes in cell culture media contributing to the variability of cell performance. References Edelfors et al. Acta Pharmacol Toxicol. 1981 Chitra et al. Indian Journal of Clinical Biochemistry 2008 Qiao et al. J Nutr Vitaminol 2013. Tarthan et al. process Biochemistry, 201