Explosive dissolution and trapping of block copolymer seed crystallites

The study of the dissolution of polymer crystals is a challenging task. Here the authors use crystallization-driven self-assembly of coil-crystalline block copolymers as a trapping technique to track the change in length of 1D seed crystallites during annealing

Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase

High-throughput screening (HTS) of ~50,000 chemical compounds against phosphorylated and unphosphorylated c-Met, a tyrosine kinase receptor for hepatocyte growth factor (HGF), was carried out in order to compare hit rates, hit potencies and also to explore scaffolds that might serve as potential leads targeting only the unphosphorylated form of the enzyme. The hit rate and potency for the confirmed hit molecules were higher for the unphosphoryalted form of c-Met. While the target of small molecule inhibitor discovery efforts has traditionally been the phosphorylated form, there are now examples of small molecules that target unphosphorylated kinases. Screening for inhibitors of unphosphorylated kinases may represent a complementary approach for prioritizing chemical scaffolds for hit-to-lead follow ups

INTERMOLECULAR COMPLEXES OF GERMANIUM(II

This thesis examines the synthesis, structural characterization, and reactivity of neutral and charged intermolecular donor complexes of germanium(II). Base stabilized complexes of dimesitylgermylene (Mes2Ge) (mes = mesityl = 2,4,6- trimethylphenyl) with either an anionic diisopropylphenyl-substituted N-heterocyclic gallium® (NHGa\u27) ligand or a diisopropyl substituted N-heterocyclic carbene (NHC) ligand were synthesized by the addition of two equivalents of either NHGa\u27 or NHC to tetramesityldigermene (Mes2Ge=GeMes2). The complexes [NHGa-GeMes2] and NHC- GeMes2 are the first two examples of a transient germylene (Mes2Ge) being stabilized by intermolecular donors. A series of NHC complexes of GefG (R = F, Cl, Br, I, CI/O3SCF3,0\u27Bu, NCS, Mes) were synthesized. The !H NMR spectra of the NHC-GeR2 complexes show broad signals at room temperature which was rationalized by either conformational interchanges or intermolecular exchanges. The NHC-GeR2 complexes were also examinedcomputationally. Theenergyofcomplexationwasfoundtodecreaseif7T donor atoms are located adjacent to the germanium centre. The reactivity of selected NHC-GeR2 (R = Cl, OlBu, or Mes) complexes towards 2,3-dimethylbutadiene, S^-di-Wtyl-orthoquinone, methyl iodide, pivalic acid and benzophenone was examined. In comparison with uncomplexed GeR2 species, the NHC-GeR2 complexes are less reactive. The prospect of using the NHC-GeR2 complexes as a synthon for GeR2 appears to be reaction specific. Finally, a series of cationic germanium(II) complexes were synthesized and characterized, including examples of germanium(II) centred dications. A germanium 111 centred dication supported by three NHC ligands [NHC3Ge][I]2 was characterized and examined computationally. The structure of (cryptand[2.2.2]Ge) , as the inflate salt, was reported and is the first example of a non-metal cation situated within a cryptand. A number cationic germanium crown ether complexes were are also synthesized including [[12]crown-4)2*Ge]2+, [[15]crown-5*GeOTf]+ and [benzo[15]crown-5•GeC1]+ and [benzo[15]crown-5•GeOTf. The geometries of the crown ether-germanium complexes were found to be highly dependent on the size of the crown ether and the substituent located on the germanium

The Anionic Ring-Opening Polymerization of N-(tolylsulfonyl)azetidines to Produce Linear Poly(trimethylenimine) and Closed-System Block-Copolymers

Files Added on Nov 8, 2018 are data made for revisions Rupar – PI Reisman – Doctoral Candidate, performed experiments and collected data Scalfani – Assisted with data sharing All processed and unprocessed data for The Anionic Polymerization of N-(tolylsulfonyl)azetidines to Produce Linear Poly(trimethylenimine) and Closed-System Block-Copolymer