4,729 research outputs found
Electromechanical Reliability Testing of Three-Axial Silicon Force Sensors
This paper reports on the systematic electromechanical characterization of a
new three-axial force sensor used in dimensional metrology of micro components.
The siliconbased sensor system consists of piezoresistive mechanicalstress
transducers integrated in thin membrane hinges supporting a suspended flexible
cross structure. The mechanical behavior of the fragile micromechanical
structure isanalyzed for both static and dynamic load cases. This work
demonstrates that the silicon microstructure withstands static forces of 1.16N
applied orthogonally to the front-side of the structure. A statistical Weibull
analysis of the measured data shows that these values are significantly reduced
if the normal force is applied to the back of the sensor. Improvements of the
sensor system design for future development cycles are derived from the
measurement results.Comment: Submitted on behalf of TIMA Editions
(http://irevues.inist.fr/tima-editions
Spectral properties of the X-ray binary pulsar LMC X-4 during different intensity states
We present spectral variations of the binary X-ray pulsar LMC X-4 observed
with the RXTE/PCA during different phases of its 30.5 day long third period.
Only out of eclipse data were used for this study. The 3-25 keV spectrum,
modeled with high energy cut-off power-law and iron line emission is found to
show strong dependence on the intensity state. Correlations between the Fe line
emission flux and different parameters of the continuum are presented here.Comment: 4 pages, 4 figure
Concentrations of Polychlorinated Biphenyls (PCBâs), Chlorinated Pesticides, and Heavy Metals and Other Elements in Tissues of Belugas, Delphinapterus leucas, from Cook Inlet
Tissues from Cook Inlet beluga whales, Delphinapterus leucas, that were collected as part of the Alaska Marine Mammal Tissue Archival Project were analyzed for polychlorinated biphenyls (PCBâs), chlorinated pesticides, and heavy metals and other elements. Concentrations of total PCBâs (ÎŁPCBâs), total DDT (ÎŁDDT), chlordane compounds, hexachlorobenzene (HCB), dieldrin, mirex, toxaphene, and hexachlorocyclohexane (HCH) measured in Cook Inlet beluga blubber were compared with those reported for belugas from two Arctic Alaska locations (Point Hope and Point Lay), Greenland, Arctic Canada, and the highly contaminated stock from the St. Lawrence estuary in eastern Canada. The Arctic and Cook Inlet belugas had much lower concentrations (ÎŁPCBâs and ÎŁDDT were an order of magnitude lower) than those found in animals from the St. Lawrence estuary. The Cook Inlet belugas had the lowest concentrations of all (ÎŁPCBâs aver-aged 1.49 ± 0.70 and 0.79 ± 0.56 mg/kg wet mass, and ÎŁDDT averaged 1.35 ± 0.73 and 0.59 ± 0.45 mg/kg in males and females, respectively). Concentrations in the blubber of the Cook Inlet males were significantly lower than those found in the males of the Arctic Alaska belugas (ÎŁPCBâs and ÎŁDDT were about half). The lower levels in the Cook Inlet animals might be due to differences in contaminant sources, food web differences, or different age distributions among the animals sampled. Cook Inlet males had higher mean and median concentrations than did females, a result attributable to the transfer of these compounds from mother to calf during pregnancy and during lactation. Liver concentrations of cadmium and mercury were lower in the Cook Inlet belugas (most cadmium values were <1 mg/kg and mercury values were 0.704â11.42 mg/kg wet mass), but copper levels were significantly higher in the Cook Inlet animals (3.97â123.8 mg/kg wet mass) than in Arctic Alaska animals and similar to those reported for belugas from Hudson Bay. Although total mercury levels were the lowest in the Cook Inlet population, methylmercury concentrations were similar among all three groups of the Alaska animals examined (0.34â2.11 mg/kg wet mass). As has been reported for the Point Hope and Point Lay belugas, hepatic concentrations of silver were r
The production of Necator americanus larvae for use in experimental human infection
Background: Although there is unprecedented interest in experimental human hookworm infection, details of hookworm manufacture and characterisation have been sparsely reported. In this report, we detail the production and characterisation of Necator americanus larvae for use in a recently published clinical trial.
Methods: Faeces was obtained from an experimentally infected donor. Faecal hookworm DNA was determined by quantitative PCR. Paired samples were incubated in either sterile water or sterile water mixed with antimicrobials (amphotericin and gentamicin). Coproculture was performed by modified Harada-Mori method. The harvested larvae were then processed in either sterile water or antiseptic solution. Larval yield was then calculated (larvae per gram), larval viability was determined by thermally induced motility assay and microbial burden was determined at the day of harvest, at 48 h and at 7 days.
Results: Twenty-eight faecal cultures were performed over 16 months. The faecal hookworm DNA content was variable over this time. There was no association of larval yield with faecal hookworm DNA content. Pre-treatment of faeces with antimicrobials did not influence larval yield. Larval motility was 85.3% (95% CI 79.3â91.3%). Incubation of larvae in antiseptics did not reduce viability at 14 days with a marginal mean of 68.6% (95% CI 59.1â78.1%) washed in water vs. 63.3% (95% CI 53.8 â 72.9%) when incubated in betadine (pâ=â0.38). Larvae washed in sterile water did not meet microbial bioburden criteria. Incubation in antiseptic resulted in acceptable microbial bioburden at 48 h but not at 7 days. Although the addition of gentamicin did reduce the microbial bio-burden acceptable levels, it was found to significantly lower larval motility at 7 days compared to incubation in sterile water and motility at 7 days 37.8% (95% CI 4.7â70.9%) vs. 67.3% (95% CI 35.2â99.3%, pâ<â0.001), respectively.
Conclusions: Despite standardised culture methodologies and the use of a single donor, larval yield varied considerably between batches and had no association with faecal hookworm DNA. Larval viability decreases over time and the age of larvae at time of use are likely to be important. Microbial bioburden maybe temporarily reduced by incubation in antiseptics and has little effect on viability. Incubation of larvae in gentamicin is effective at reducing microbial bioburden but is deleterious to larval viability
Platelet Function Monitoring in Patients With Coronary Artery Disease
Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing
Simulated LSST Survey of RR Lyrae Stars throughout the Local Group
We report on a study to determine the efficiency of the Large Synoptic Survey Telescope (LSST) to recover the periods, brightnesses, and shapes of RR Lyrae stars' light curves in the volume extending to heliocentric distances of 1.5 Mpc. We place the smoothed light curves of 30 type ab and 10 type c RR Lyrae stars in 1007 fields across the sky, each of which represents a different realization of the LSST sampling cadences, and that sample five particular observing modes. A light curve simulation tool was used to sample the idealized RR Lyrae stars' light curves, returning each as it would have been observed by LSST, including realistic photometric scatter, limiting magnitudes, and telescope downtime. We report here the period, brightness, and light curve shape recovery as a function of apparent magnitude and for survey lengths varying from 1 to 10 years. We find that 10 years of LSST data are sufficient to recover the pulsation periods with a fractional precision of ~10^(â5) for â„90% of ab stars within â360 kpc of the Sun in Universal Cadence fields and out to â760 kpc for Deep Drilling fields. The 50% completeness level extends to â600 kpc and â1.0 Mpc for the same fields, respectively. For virtually all stars that had their periods recovered, their light curve shape parameter Ï_31 was recovered with sufficient precision to also recover photometric metallicities to within 0.14 dex (the systematic error in the photometric relations). With RR Lyrae stars' periods and metallicities well measured to these distances, LSST will be able to search for halo streams and dwarf satellite galaxies over half of the Local Group, informing galaxy formation models and providing essential data for mapping the Galactic potential. This study also informs the LSST science operations plan for optimizing observing strategies to achieve particular science goals. We additionally present a new [Fe/H]-Ï_31 photometric relation in the r band and a new and generally useful metric for defining period recovery for time domain surveys
The mechanically induced structural disorder in barium hexaferrite, BaFe12O19, and its impact on magnetism
The response of the structure of the M-type barium hexaferrite (BaFe12O19) to mechanical action through high-energy milling and its impact on the magnetic behaviour of the ferrite are investigated. Due to the ability of the Fe-57 Mossbauer spectroscopic technique to probe the environment of the Fe nuclei, a valuable insight on a local atomic scale into the mechanically induced changes in the hexagonal structure of the material is obtained. It is revealed that the milling of BaFe12O19 results in the deformation of its constituent polyhedra (FeO6 octahedra, FeO4 tetrahedra and FeO5 triangular bi-pyramids) as well as in the mechanically triggered transition of the Fe3+ cations from the regular 12k octahedral sites into the interstitial positions provided by the magnetoplumbite structure. The response of the hexaferrite to the mechanical treatment is found to be accompanied by the formation of a non-uniform nanostructure consisting of an ordered crystallite surrounded/separated by a structurally disordered surface shell/interface region. The distorted polyhedra and the non-equilibrium cation distribution are found to be confined to the amorphous near-surface layers of the ferrite nanoparticles with the thickness extending up to about 2 nm. The information on the mechanically induced short-range structural disorder in BaFe12O19 is complemented by an investigation of its magnetic behaviour on a macroscopic scale. It is demonstrated that the milled ferrite nanoparticles exhibit a pure superparamagnetism at room temperature. As a consequence of the far-from-equilibrium structural disorder in the surface shell of the nanoparticles, the mechanically treated BaFe12O19 exhibits a reduced magnetization and an enhanced coercivity.DFG/SPP/1415APVV/0528-11VEGA/2/0097/1
Oxygen Moment Formation and Canting in Li2CuO2
The possibilities of oxygen moment formation and canting in the quasi-1D
cuprate Li2CuO2 are investigated using single crystal neutron diffraction at 2
K. The observed magnetic intensities could not be explained without the
inclusion of a large ordered oxygen moment of 0.11(1) Bohr magnetons.
Least-squares refinement of the magnetic structure of Li2CuO2 in combination
with a spin-density Patterson analysis shows that the magnetization densities
of the Cu and O atoms are highly aspherical, forming quasi-1D ribbons of
localised Cu and O moments. Magnetic structure refinements and low-field
magnetization measurements both suggest that the magnetic structure of Li2CuO2
at 2 K may be canted. A possible model for the canted configuration is
proposed.Comment: 10 pages, 8 figures (screen resolution
The conjugacy problem for the automorphism group of the random graph
We prove that the conjugacy problem for the automorphism group of the random
graph is Borel complete, and discuss the analogous problem for some other
countably categorical structures.Comment: 7 page
Reionization: Characteristic Scales, Topology and Observability
Recently the numerical simulations of the process of reionization of the
universe at z>6 have made a qualitative leap forward, reaching sufficient sizes
and dynamic range to determine the characteristic scales of this process. This
allowed making the first realistic predictions for a variety of observational
signatures. We discuss recent results from large-scale radiative transfer and
structure formation simulations on the observability of high-redshift Ly-alpha
sources. We also briefly discuss the dependence of the characteristic scales
and topology of the ionized and neutral patches on the reionization parameters.Comment: 4 pages, 5 figures (4 in color), to appear in Astronomy and Space
Science special issue "Space Astronomy: The UV window to the Universe",
proceedings of 1st NUVA Conference ``Space Astronomy: The UV window to the
Universe'' in El Escorial (Spain
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