Diversity in Central Asia: Culture, transition & entrepreneurship

With the demise of the USSR in 1991, five new countries became independent in Central Asia. This study presents an overview about transition, emergence and nature of entrepreneurship in a world’s region that displays amongst the most important energy resources in gas and oil

Cell cycle regulation of a Xenopus Wee1-like kinase

Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner. The addition of exogenous Wee1 protein to Xenopus cell cycle extracts results in a dose-dependent delay of mitotic initiation that is accompanied by enhanced tyrosine phosphorylation of Cdc2. The activity of the Wee1 protein is highly regulated during the cell cycle: the interphase, underphosphorylated form of Wee1 (68 kDa) phosphorylates Cdc2 very efficiently, whereas the mitotic, hyperphosphorylated version (75 kDa) is weakly active as a Cdc2-specific tyrosine kinase. The down-modulation of Wee1 at mitosis is directly attributable to phosphorylation, since dephosphorylation with protein phosphatase 2A restores its kinase activity. During interphase, the activity of this Wee1 homolog does not vary in response to the presence of unreplicated DNA. The mitosis-specific phosphorylation of Wee1 is due to at least two distinct kinases: the Cdc2 protein and another activity (kinase X) that may correspond to an MPM-2 epitope kinase. These studies indicate that the down-regulation of Wee1-like kinase activity at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase

Textpresso for Neuroscience: Searching the Full Text of Thousands of Neuroscience Research Papers

Textpresso is a text-mining system for scientific literature. Its two major features are access to the full text of research papers and the development and use of categories of biological concepts as well as categories that describe or relate objects. A search engine enables the user to search for one or a combination of these categories and/or keywords within an entire literature. Here we describe Textpresso for Neuroscience, part of the core Neuroscience Information Framework (NIF). The Textpresso site currently consists of 67,500 full text papers and 131,300 abstracts. We show that using categories in literature can make a pure keyword query more refined and meaningful. We also show how semantic queries can be formulated with categories only. We explain the build and content of the database and describe the main features of the web pages and the advanced search options. We also give detailed illustrations of the web service developed to provide programmatic access to Textpresso. This web service is used by the NIF interface to access Textpresso. The standalone website of Textpresso for Neuroscience can be accessed at http://www.textpresso.org/neuroscience

A Philosophical Analysis of Chet Bowers’ Ethical Theory of EcoJustice: Shifting towards Uncertainty Thinking in Science Education

The purpose of this study is to analyze Chet Bowers’ ethical theory of ecojustice as the basis of an ecological philosophy of education that recognizes Earth’s uncertainty. Bowers’ main thesis is that the commons, or what were once shared by members of the community, should be strengthened by education reforms based on ecojustice criteria. He argues for certain ideologies of the local authority of the commons, “Western” science and scientists, and the “ecological crisis.” I argue that these certainties are uncertain, which justifies part certainty as deciphered by local people in places, in relation to others. Further, I develop a theory of ecological pragmatism, or thinking with uncertainty, grounded by the classical American pragmatist theory of John Dewey and other scholars. My expectation is to empower science teachers and their students to become informed, and share some of the responsibility for participating in local decisions as stakeholders and advocates for local communities, cultural diversity, and Earth’s diverse ecosystems