691 research outputs found
Atmospheric pressure chemical ionisation mass spectrometry for the routine analysis of low molecular weight analytes
An LC-MS/MS Analysis of Opiate Residues on Thomas Chatterton’s (1752-1770) Memorandum Book:Did he Die from a Laudanum Overdose?
Characterisation of Flavonoid Aglycones by Negative Ion Chip-Based Nanospray Tandem Mass Spectrometry
Flavonoids are one of the most important classes of natural products having a wide variety of biological activities. There is wide interest in a range of medical and dietary applications, and having a rapid, reliable method for structural elucidation is essential. In this study a range of flavonoid standards are investigated by chip-based negative ion nanospray mass spectrometry. It was found that the different classes of flavonoid studied have a combination of distinct neutral losses from the precursor ion [M-H]− along with characteristic low-mass ions. By looking only for this distinct pattern of product ions, it is possible to determine the class of flavonoid directly. This methodology is tested here by the analysis of a green tea extract, where the expected flavonoids were readily identified, along with quercetin, which is shown to be present at only about 2% of the most intense ion in the spectrum
A computational and experimental study of the fragmentation of L-leucine, L-isoleucine and L-allo-isoleucine under collision-induced dissociation tandem mass spectrometry.
Identification of β-Carotene Oxidation Products Produced by Bleaching Clay Using UPLC-ESI-MS/MS
A study of the application of graphite MALDI to the analysis of short-chain polyethylene glycols
Linear and star architecture methacrylate-functionalised PDMS
Methacrylate-terminated poly(dimethylsiloxane)s in both linear and star architectures have been produced through a time-efficient 1 pot, 2 stage reaction which involved hydrosilylation of small molecule silanes with allyl methacrylate and subsequent equilibration of the product with octamethylcyclotetrasiloxane (D4) in the presence of an acid catalyst. This synthetic route required only one work-up procedure and the products were comparable to those produced by 2 step processes typically reported in literature. All methacrylate-terminated products were approximately double the molar masses anticipated based on reagent loadings. This is thought to be due to redistribution of siloxane bonds in the presence of the platinum hydrosilylation catalyst accompanied by a loss of silicon from the reaction by evaporation of dimethylsilane. It is believed that this is the first report of such siloxane equilibration occurring at room temperature
The Synthesis of Mycobacterial Dimycoloyl Diarabinoglycerol Based on Defined Synthetic Mycolic Acids
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