Progressive associative phonagnosia: A neuropsychological analysis

AbstractThere are few detailed studies of impaired voice recognition, or phonagnosia. Here we describe two patients with progressive phonagnosia in the context of frontotemporal lobar degeneration. Patient QR presented with behavioural decline and increasing difficulty recognising familiar voices, while patient KL presented with progressive prosopagnosia. In a series of neuropsychological experiments we assessed the ability of QR and KL to recognise and judge the familiarity of voices, faces and proper names, to recognise vocal emotions, to perceive and discriminate voices, and to recognise environmental sounds and musical instruments. The patients were assessed in relation to a group of healthy age-matched control subjects. QR exhibited severe impairments of voice identification and familiarity judgments with relatively preserved recognition of difficulty-matched faces and environmental sounds; recognition of musical instruments was impaired, though better than recognition of voices. In contrast, patient KL exhibited severe impairments of both voice and face recognition, with relatively preserved recognition of musical instruments and environmental sounds. Both patients demonstrated preserved ability to analyse perceptual properties of voices and to recognise vocal emotions. The voice processing deficit in both patients could be characterised as associative phonagnosia: in the case of QR, this was relatively selective for voices, while in the case of KL, there was evidence for a multimodal impairment of person knowledge. The findings have implications for current cognitive models of voice recognition

Tracking cortical entrainment in neural activity: auditory processes in human temporal cortex.

A primary objective for cognitive neuroscience is to identify how features of the sensory environment are encoded in neural activity. Current auditory models of loudness perception can be used to make detailed predictions about the neural activity of the cortex as an individual listens to speech. We used two such models (loudness-sones and loudness-phons), varying in their psychophysiological realism, to predict the instantaneous loudness contours produced by 480 isolated words. These two sets of 480 contours were used to search for electrophysiological evidence of loudness processing in whole-brain recordings of electro- and magneto-encephalographic (EMEG) activity, recorded while subjects listened to the words. The technique identified a bilateral sequence of loudness processes, predicted by the more realistic loudness-sones model, that begin in auditory cortex at ~80 ms and subsequently reappear, tracking progressively down the superior temporal sulcus (STS) at lags from 230 to 330 ms. The technique was then extended to search for regions sensitive to the fundamental frequency (F0) of the voiced parts of the speech. It identified a bilateral F0 process in auditory cortex at a lag of ~90 ms, which was not followed by activity in STS. The results suggest that loudness information is being used to guide the analysis of the speech stream as it proceeds beyond auditory cortex down STS toward the temporal pole.This work was supported by an EPSRC grant to William D. Marslen-Wilson and Paula Buttery (EP/F030061/1), an ERC Advanced Grant (Neurolex) to William D. Marslen-Wilson, and by MRC Cognition and Brain Sciences Unit (CBU) funding to William D. Marslen-Wilson (U.1055.04.002.00001.01). Computing resources were provided by the MRC-CBU and the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/). Andrew Liu and Phil Woodland helped with the HTK speech recogniser and Russell Thompson with the Matlab code. We thank Asaf Bachrach, Cai Wingfield, Isma Zulfiqar, Alex Woolgar, Jonathan Peelle, Li Su, Caroline Whiting, Olaf Hauk, Matt Davis, Niko Kriegeskorte, Paul Wright, Lorraine Tyler, Rhodri Cusack, Brian Moore, Brian Glasberg, Rik Henson, Howard Bowman, Hideki Kawahara, and Matti Stenroos for invaluable support and suggestions.This is the final published version. The article was originally published in Frontiers in Computational Neuroscience, 10 February 2015 | doi: 10.3389/fncom.2015.0000

Immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density and shedding, and middle ear infection in mice

Pneumococcal Conjugate Vaccines (PCVs) have substantially reduced the burden of disease caused by Streptococcus pneumoniae (the pneumococcus). However, protection is limited to vaccine serotypes, and when administered to children who are colonized with pneumococci at the time of vaccination, immune responses to the vaccine are blunted. Here, we investigate the potential of a killed whole cell pneumococcal vaccine (WCV) to reduce existing pneumococcal carriage and mucosal disease when given therapeutically to infant mice colonized with pneumococci. We show that a single dose of WCV reduced pneumococcal carriage density in an antibody-dependent manner. Therapeutic vaccination induced robust immune responses to pneumococcal surface antigens CbpA, PspA (family 1) and PiaA. In a co-infection model of otitis media, a single dose of WCV reduced pneumococcal middle ear infection. Lastly, in a two-dose model, therapeutic administration of WCV reduced nasal shedding of pneumococci. Taken together, our data demonstrate that WCV administered in colonized mice reduced pneumococcal density in the nasopharynx and the middle ear, and decreased shedding. WCVs would be beneficial in low and middle-income settings where pneumococcal carriage in children is high

Convergence Acceleration via Combined Nonlinear-Condensation Transformations

A method of numerically evaluating slowly convergent monotone series is described. First, we apply a condensation transformation due to Van Wijngaarden to the original series. This transforms the original monotone series into an alternating series. In the second step, the convergence of the transformed series is accelerated with the help of suitable nonlinear sequence transformations that are known to be particularly powerful for alternating series. Some theoretical aspects of our approach are discussed. The efficiency, numerical stability, and wide applicability of the combined nonlinear-condensation transformation is illustrated by a number of examples. We discuss the evaluation of special functions close to or on the boundary of the circle of convergence, even in the vicinity of singularities. We also consider a series of products of spherical Bessel functions, which serves as a model for partial wave expansions occurring in quantum electrodynamic bound state calculations.Comment: 24 pages, LaTeX, 12 tables (accepted for publication in Comput. Phys. Comm.

Search for the Decay τ−→4pi−3π+(π0)ντ\tau^{-}\to 4pi^{-}3\pi^{+}(\pi^{0})\nu_{\tau}

We have searched for the decay of the tau lepton into seven charged particles and zero or one pi0. The data used in the search were collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR) and correspond to an integrated luminosity of 4.61 fb^(-1). No evidence for a signal is found. Assuming all the charged particles are pions, we set an upper limit on the branching fraction, B(tau- -> 4pi- 3pi+ (pi0) nu_tau) < 2.4 x 10^(-6) at the 90% confidence level. This limit represents a significant improvement over the previous limit.Comment: 9 page postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN

Flavor-Specific Inclusive B Decays to Charm

We have measured the branching fractions for B -> D_bar X, B -> D X, and B -> D_bar X \ell^+ \nu, where ``B'' is an average over B^0 and B^+, ``D'' is a sum over D^0 and D^+, and``D_bar'' is a sum over D^0_bar and D^-. From these results and some previously measured branching fractions, we obtain Br(b -> c c_bar s) = (21.9 $\pm$ 3.7)%, Br(b -> s g) K^- \pi^+) = (3.69 $\pm$ 0.20)%. Implications for the ``B semileptonic decay problem'' (measured branching fraction being below theoretical expectations) are discussed. The increase in the value of Br(b -> c c_bar s) due to $B -> D X$ eliminates 40% of the discrepancy.Comment: 12 page postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN

Measurement of Br(D0→K−π+)Br(D^{0}\to K^{-}\pi^{+}) using Partila Reconstruction of Bˉ→D∗+Xℓ−νˉ\bar{B}\to D^{*+}X\ell^{-}\bar{\nu}

We present a measurement of the absolute branching fraction for $D^0 -> K^- pi^+$ using the reconstruction of the decay chain $Bbar -> D^{*+} X l^- nubar$, $D^{*+} -> D^0 pi^+$ where only the lepton and the low-momentum pion from the $D^{*+}$ are detected. With data collected by the CLEO II detector at the Cornell Electron Storage Ring, we have determined $Br(D^0 -> K^- pi^+)= [3.81 +- 0.15(stat.) +- 0.16(syst.)]$.Comment: 10 page postscript file, postscript file also available through http://w4.lns.cornell.edu/public/CLN

Measurement of the Bˉ→Dℓνˉ\bar{B}\to D\ell\bar{\nu} Partila Width and Form Factor Parameters

We have studied the decay $\bar{B} \to D\ell\bar{\nu}$, where $\ell=e or \mu$. From a fit to the differential decay rate $d\Gamma/dw$ we measure the rate normalization ${\cal F}_D(1)|V_{cb}|$ and form factor slope $\hat{\rho}^2_D$, and, using measured values of $\tau_B$, find $\Gamma(\bar{B} \to D\ell\bar{\nu}) = (12.0 \pm 0.9 \pm 2.1) ns^{-1}$. The resulting branching fractions are ${\cal B}(\bar{B}^0 \to D^+\ell^-\bar{\nu})=(1.87 \pm 0.15 \pm 0.32)$ and ${\cal B}(B^- \to D^0\ell^-\bar{\nu})=(1.94 \pm 0.15 \pm 0.34)$. The form factor parameters are in agreement with those measured in $\bar{B} \to D^*\ell\bar{\nu}$ decays, as predicted by heavy quark effective theory.Comment: 11 pages, postscript file also available through http://w4.lns.cornell.edu/public/CLN