A randomised controlled trial of oral misoprostol vs injection methylergometrine for prevention of post partum hemorrhage

Background: To compare the efficacy of 600mcg of oral misoprostol with 0.2mg of injection methylergometrine for the prevention of post partum hemorrhage.Methods: 200 apparently normal pregnant women were randomized to receive either 600mcg of oral misoprostol (study group) after delivery of baby or 0.2 mg of methylergometrine intravenously (control group) after delivery of placenta. Primary outcome was to know the incidence of post partum hemorrhage in both the groups. Secondary outcome measures were to look for mean blood loss, need for any other uterotonic agents, need for blood transfusion, need for surgical intervention, mean duration of third stage and side effects of both the drugs.Results: Out of 200 cases, two cases were excluded for the final analysis. Incidence of PPH was 9% in misoprostol group & 6% in methylergometrine group which was not significant (p >0.05). There were no significant differences among both the groups in mean blood loss, duration of bleeding, need for further oxytocics and duration of third stage. Shivering was significantly more common in misoprostol group (36% Vs 2% p< 0.0027). Conclusion: Efficacy of 600mcg of oral misoprostol is comparable to injection methylergometrine 0.2 mg intravenously for prevention of post partum hemorrhage. So, in settings where methylergometrine is used routinely for prophylaxis, oral misoprostol can be used with more ease & other advantages over injectables. Significantly more number of patients in misoprostol will have shivering as a major side effect, which should be kept in mind

Variability for grain mold resistance in sorghum F3 progenies of red × red and red × white grain crosses

The present investigation was carried out to estimate the nature and magnitude of genetic variability for yield and grain moldresistance in 99 sorghum F3 progenies of red × red and red × white crosses including parents and checks. Variation for grain moldassociated traits was analyzed with respect to grain hardness, panicle compactness, grain colour, glume length and glume colour.Among 99 F3 progenies 30 progenies exhibited partly hard grains and 19 progenies had hard grains and which exhibited lowincidence of grain mold. In case of panicle compactness, 6 progenies had very loose, 9 progenies had loose and 26 progenies hadsemi-loose panicles and exhibited low incidence of grain mold. Twenty one progenies and seven progenies had long glumecoverage and very long glume coverage respectively and these were resistant to grain mold. All the red grain coloured progeniesshowed low incidence of grain mold and progenies which had red and black coloured glumes were moderately resistant.Genotypes with hard grains, loose panicles, medium to long glume coverage and red and black coloured glumes had lowincidence of grain mold. First and eleventh F3 progenies of IS 24995 × IS 23585, first and ninth progeny of IS 24996 × IS 23585and 8th progeny of IS 25022 × IS 23585 were high yielding and resistant to grain mold

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