4 research outputs found
Structure of human heat-shock transcription factor 1 in complex with DNA
- Author
- A Fiser
- A Fiser
- A Metz
- A Sali
- A Sandqvist
- AA Vagin
- AM Catanzariti
- AM Jaeger
- Andreas Bracher
- B Calamini
- BA Morgan
- C Dai
- C Jolly
- C Jolly
- C Wu
- CJ Harrison
- DL Grady
- DW Neef
- DW Neef
- DW Neef
- E Zelin
- EF Pettersen
- F Ulrich Hartl
- G French
- G Langer
- G Wiederrecht
- GM Sheldrick
- GN Murshudov
- GT Kleywegt
- GW Vuister
- H Xiao
- H Xiao
- HR Pelham
- J Amin
- J Anckar
- J Treisman
- J Zou
- J Zuo
- Jacob Verghese
- JS Fassler
- JS Larson
- K Abravaya
- K Nadeau
- KD Sarge
- KE Flick
- L Tucker-Kellogg
- M Denegri
- M Lu
- M Ă…kerfelt
- Manajit Hayer-Hartl
- ML Mendillo
- MP Kline
- N Pattaramanon
- O Littlefield
- P Emsley
- P Evans
- P Gouet
- PA Mercier
- PJ Wyatt
- PK Sorger
- PR Evans
- PR Evans
- R Baler
- R Peteranderl
- R Scherz-Shouval
- RI Morimoto
- RI Morimoto
- RM Vabulas
- S Li
- S Li
- S Raychaudhuri
- S Santagata
- SD Westerheide
- SG Ahn
- SK Rabindran
- SV Alarcon
- T Pape
- Tobias Neudegger
- V Hietakangas
- W Kabsch
- WE Balch
- X Xiao
- Y Shi
- YE Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
- Author
- Abe T.
- Abe T.
- Abravaya K.
- Ahn S. G.
- Ali A.
- Allison A. C.
- Amici C.
- Amin J.
- Anckar J.
- Balch W. E.
- Baler R.
- Baler R.
- Batthyany C.
- Batulan Z.
- Becker J.
- Beere H. M.
- Beere H. M.
- Ben-Zvi A.
- Bienz M.
- Bieschke J.
- Boellmann F.
- Bonner J. J.
- Borrelli M. J.
- Bossis G.
- Brodsky J. L.
- Brown K. K.
- Brunet A.
- Bulteau A. L.
- Burcham P. C.
- Caito S.
- Cajone F.
- Calamini B.
- Calderwood S. K.
- Carbone D. L.
- Carbone D. L.
- Casini A.
- Chadli A.
- Chan H. Y.
- Chao P. L.
- Chapman A. L.
- Claiborne A.
- Clay C. E.
- Codreanu S. G.
- Cohen E.
- Conde R.
- Conde R.
- Connor R. E.
- Cotto J.
- Craig E. A.
- Craig E. A.
- Csermely P.
- Dai C.
- Davies M. J.
- Dickinson B. C.
- Dinkova-Kostova A. T.
- Dinkova-Kostova A. T.
- D’Autreaux B.
- Evgrafov O. V.
- Fawcett T. W.
- Gan N.
- Gidalevitz T.
- Gidalevitz T.
- Guettouche T.
- Guo Y.
- Harrison C. J.
- Hartl F. U.
- Hartl F. U.
- Hermawan A.
- Heydari A. R.
- Hieronymus H.
- Hietakangas V.
- Hietakangas V.
- Hilgarth R. S.
- Holbrook N. J.
- Holmberg C. I.
- Homma S.
- Hong Y.
- Hsu A. L.
- Hur W.
- Hyun D. H.
- Jacobs A. T.
- Jakobsen B. K.
- Jakobsen B. K.
- James D. West
- Jolly C.
- Jurivich D. A.
- Kaarniranta K.
- Kamada M.
- Kanfi Y.
- Kansanen E.
- Katsuno M.
- Kevin A. Morano
- Khong T.
- Kim D.
- Klaic L.
- Kline M. P.
- Knauf U.
- Kon M.
- Kondo M.
- Lawson B.
- Le Moan N.
- Lee P.
- Leonard S. E.
- Levinson W.
- Liebler D. C.
- Lindquist S.
- Liu H.
- Liu Q.
- Liu X. Y.
- Liu Y.
- Liu Z.
- Locke M.
- Lu M.
- Lu M.
- Mager W. H.
- Manalo D. J.
- Manalo D. J.
- Marnett L. J.
- Marozkina N. V.
- Mayya V.
- McMillan D. R.
- Mikuriya T.
- Morano K. A.
- Morano K. A.
- Mori K.
- Mori-Iwamoto S.
- Morimoto R. I.
- Morimoto R. I.
- Morley J. F.
- Morley J. F.
- Morrow G.
- Morrow G.
- Moulis J. M.
- Mu T. W.
- Mu T. W.
- Mullally J. E.
- Murata M.
- Nadkarni D. V.
- Nakai A.
- Neckers L.
- Neef D. W.
- Neef D. W.
- Nemani R.
- Nollen E. A.
- Olsen J. V.
- Olsen J. V.
- Ong D. S.
- Osburn W. O.
- Otaka M.
- Pattaramanon N.
- Paulsen C. E.
- Perdrizet G. A.
- Perez-Sala D.
- Perisic O.
- Peteranderl R.
- Peteranderl R.
- Powers E. T.
- Rabindran S. K.
- Rabindran S. K.
- Rahmani M.
- Rand J. D.
- Rossi A.
- Rudolph T. K.
- Salomons F. A.
- Sanchez Y.
- Sanchez Y.
- Sanchez-Gomez F. J.
- Santagata S.
- Santagata S.
- Santoro M. G.
- Sarge K. D.
- Schett G.
- Schlesinger M. J.
- Schulte T. W.
- Sharma S. K.
- Shi Y.
- Shi Y.
- Shibata T.
- Siegel S. J.
- Singh O. V.
- Soncin F.
- Soto C.
- Sreeramulu S.
- Steinkraus K. A.
- Stepanova L.
- Stone D. E.
- Sykiotis G. P.
- Taipale M.
- Tanabe M.
- Tang D.
- Thompson C. A.
- Trott A.
- Uchida K.
- Vargas-Roig L. M.
- Vila A.
- Voellmy R.
- Walter P.
- Wandinger S. K.
- Wang X.
- Wang Y.
- Weerapana E.
- West J. D.
- West J. D.
- West J. D.
- West J. D.
- Westerheide S. D.
- Westerheide S. D.
- Westerheide S. D.
- Westwood J. T.
- Wilde I. B.
- Winter J.
- Winterbourn C. C.
- Woods C. G.
- Wu C.
- Wu J.
- Xia W.
- Yang H.
- Yang H.
- Yanyu Wang
- Yasuda H.
- Zhang Q.
- Zhang Y.
- Zhang Y.
- Zhong M.
- Zou J.
- Zou J.
- Publication venue
- Open Works
- Publication date
- 01/01/2012
- Field of study
All cells have developed various mechanisms to respond and adapt to a variety of environmental challenges, including stresses that damage cellular proteins. One such response, the heat shock response (HSR), leads to the transcriptional activation of a family of molecular chaperone proteins that promote proper folding or clearance of damaged proteins within the cytosol. In addition to its role in protection against acute insults, the HSR also regulates lifespan and protects against protein misfolding that is associated with degenerative diseases of aging. As a result, identifying pharmacological regulators of the HSR has become an active area of research in recent years. Here, we review progress made in identifying small molecule activators of the HSR, what cellular targets these compounds interact with to drive response activation, and how such molecules may ultimately be employed to delay or reverse protein misfolding events that contribute to a number of diseases. © 2012 American Chemical Society
Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System
- Author
- Abbas-Terki T
- Abbas-Terki T
- Aguilaniu H
- Ahn SG
- Akerfelt M
- Alepuz PM
- Ali MM
- Andreasson C
- Andrew AJ
- Azevedo D
- Bagola K
- Baler R
- Bali M
- Batista-Nascimento L
- Baumann F
- Beck T
- Bell SL
- Benaroudj N
- Bergeron JJM
- Bernales S
- Berry DB
- Blumberg H
- Boisrame A
- Bomer U
- Bonner JJ
- Bosis E
- Brejning J
- Brizzio V
- Brodsky JL
- Brodsky JL
- Brown AJ
- Buchan JR
- Buck TM
- Bulman AL
- Burnie JP
- Cabib E
- Cabib E
- Cai H
- Camasses A
- Campuzano V
- Caplan AJ
- Caplan AJ
- Carmody SR
- Carrascosa JL
- Carratu L
- Caruso M
- Cashikar AG
- Cashikar AG
- Causton HC
- Chen T
- Chen Y
- Cheng MY
- Cho HS
- Chung N
- Cicero MP
- Conde R
- Conlin LK
- Conz C
- Corsi AK
- Cowart LA
- Cowart LA
- Cox JS
- Craig EA
- Craig EA
- Craig EA
- Craig EA
- Craven RA
- Creusot F
- Crowe JH
- Cyert MS
- Cyr DM
- D'Silva PD
- D'Silva PR
- de Jong WW
- de Keyzer J
- De Wever V
- Decker CJ
- Delaunay A
- DeRisi JL
- Deshaies RJ
- Dickson RC
- Dickson RC
- DiSalvo S
- Dombek KM
- Doyle SM
- Dragovic Z
- Dragovic Z
- Drees BL
- Dubaquie Y
- Duina AA
- Duina AA
- Dutkiewicz R
- Easton DP
- Echtenkamp FJ
- Ellgaard L
- Ellis J
- Erjavec N
- Eroles P
- Erzberger JP
- Estruch F
- Estruch F
- Farquhar R
- Ferguson SB
- Flaherty KM
- Flick KE
- Flom G
- Flom GA
- Forafonov F
- Fraschini R
- Frazier AE
- Freedman RB
- Freeman BC
- Frydman J
- Frydman J
- Gambill BD
- Gardner BM
- Garreau H
- Gasch AP
- Gautschi M
- Germaniuk A
- Gething MJ
- Ghaemmaghami S
- Giaever G
- Gillece P
- Glick BS
- Gong Y
- Gorner W
- Gorner W
- Gorner W
- Greene MK
- Gross C
- Grousl T
- Hahn JS
- Hainzl O
- Hamman BD
- Harris N
- Harrison CJ
- Hartl FU
- Hashikawa N
- Hashikawa N
- Haslbeck M
- Haslbeck M
- Haslbeck M
- Haslbeck M
- Haslbeck M
- Heck JW
- Hessling M
- Hettema EH
- Heyrovska N
- Hieronymus H
- Ho AK
- Hohfeld J
- Hoj A
- Hon T
- Horst M
- Horton LE
- Hubl ST
- Hundley H
- Ihara Y
- Izawa S
- Jakob CA
- Jakob U
- Jakobsen BK
- James P
- Jenkins GM
- Jenkins GM
- Jermy AJ
- Jiang J
- Johnson BD
- Johnson JL
- Johnson JL
- Johnson JL
- Johnson MK
- Kabani M
- Kabani M
- Kabani M
- Kabir MA
- Kaganovich D
- Kamada Y
- Kampinga HH
- Kang PJ
- Kim R
- Kim S
- Kimura T
- Kimura T
- Knight SA
- Kobayashi N
- Kozany C
- Krzewska J
- Kusakabe T
- Laloraya S
- Lan C
- Lawson B
- Lee DH
- Lee P
- Lee P
- Lee P
- Lee S
- Lee S
- Levine RL
- Levy EJ
- Li J
- Li XS
- Li Y
- Lindquist S
- Lindquist S
- Littlefield O
- Liu B
- Liu Q
- Liu XD
- Liu XD
- Liu Z
- Louvion JF
- Lum R
- Lutz T
- Lyles MM
- Lyman SK
- Mackay RG
- Malcher M
- Mandal AK
- Mandal AK
- Maneu V
- Maneu V
- Martin H
- Martin J
- Martinez-Pastor MT
- Matlack KES
- Matsumoto R
- Mayordomo I
- McClellan AJ
- McClellan AJ
- McCracken AA
- Meier KD
- Meyer AE
- Meyer P
- Miao B
- Minchiotti G
- Mir SS
- Mizunaga T
- Moczko M
- Mokranjac D
- Mokranjac D
- Mokranjac D
- Mollapour M
- Morano KA
- Morimoto RI
- Morishima N
- Moro F
- Motshwene P
- Mukai H
- Nathan DF
- Neef DW
- Neef DW
- Nelson RJ
- Nelson RJ
- Neupert W
- Ng DT
- Nieto-Sotelo J
- Nillegoda NB
- Nishikawa S
- Nishikawa SI
- Norgaard P
- Normington K
- Nwaka S
- Ostermann J
- Pais JE
- Panaretou B
- Pareek G
- Paris S
- Parker R
- Parlati F
- Parsell DA
- Pattaramanon N
- Peisker K
- Perisic O
- Peteranderl R
- Peteranderl R
- Pfeifer K
- Pfund C
- Pfund C
- Piper PW
- Piper PW
- Plemper RK
- Polier S
- Portillo F
- Prodromou C
- Puig A
- Rabindran SK
- Raboy B
- Ran F
- Rao J
- Rassow J
- Rauch T
- Raviol H
- Raviol H
- Reading DS
- Requena JR
- Rezaie S
- Ribeiro MJ
- Richter K
- Robbins N
- Roe SM
- Rollenhagen C
- Rose MD
- Rospert S
- Rottgers K
- Rowley N
- Saavedra C
- Saavedra CA
- Sadeh A
- Sadler I
- Sadlish H
- Sahi C
- Sakurai H
- Sales K
- Sanchez Y
- Sanchez Y
- Sanders SL
- Saris N
- Satyanarayana C
- Scherer PE
- Scheufler C
- Schilke B
- Schilke B
- Schirmer EC
- Schlenstedt G
- Schmidt S
- Schmitt AP
- Schmitt M
- Schmitt M
- Schneider HC
- Schneider HC
- Schrag JD
- Schuermann JP
- Schulte TW
- Scidmore MA
- Sewell AK
- Seymour IJ
- Shahi P
- Shaner L
- Shaner L
- Shaner L
- Shaner L
- Shao J
- Shao J
- Shapiro RS
- Sharma D
- Shearer G
- Shimon L
- Shulga N
- Sichting M
- Siegers K
- Sielaff B
- Silberstein S
- Siligardi G
- Simola M
- Simon SM
- Simons JF
- Singer MA
- Singer MA
- Somer L
- Sondermann H
- Song JL
- Song Y
- Sorger PK
- Sorger PK
- Sorger PK
- Sorger PK
- Sorger PK
- Steel GJ
- Stirling PC
- Stoldt V
- Strain J
- Stromer T
- Stromer T
- Summers DW
- Tachikawa H
- Tachikawa H
- Tachikawa H
- Thanonkeo P
- Thomas G
- Toogun OA
- Travers KJ
- Treger JM
- Treger JM
- Trott A
- Trotter EW
- Trotter EW
- Truscott KN
- Tsai J
- Tyson JR
- Unal E
- Unno K
- Valpuesta JM
- Van Dyck L
- Vembar SS
- Verges E
- Vinh DB
- Voellmy R
- Voellmy R
- Vogel JP
- Vogel M
- Vogel M
- Voisine C
- von Janowsky B
- von Plehwe U
- Voos W
- Voos W
- Wagner I
- Walker KW
- Wandinger SK
- Wandinger SK
- Wang Q
- Wegele H
- Weitzmann A
- Welker S
- Wells GB
- Wendler P
- Wendler P
- Wera S
- Werner-Washburne M
- Westerheide SD
- Westermann B
- Westwood JT
- Wiederrecht G
- Wieser R
- Wotton D
- Wright CM
- Xiao J
- Xu X
- Xu X
- Xu Y
- Yam AY
- Yamamoto N
- Yao Y
- Youker RT
- Zarzov P
- Zhang W
- Zhao R
- Zhong T
- Zhou C
- Zu T
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
- Author
- Abe T.
- Abe T.
- Abravaya K.
- Ahn S. G.
- Ali A.
- Allison A. C.
- Amici C.
- Amin J.
- Anckar J.
- Balch W. E.
- Baler R.
- Baler R.
- Batthyany C.
- Batulan Z.
- Becker J.
- Beere H. M.
- Beere H. M.
- Ben-Zvi A.
- Bienz M.
- Bieschke J.
- Boellmann F.
- Bonner J. J.
- Borrelli M. J.
- Bossis G.
- Brodsky J. L.
- Brown K. K.
- Brunet A.
- Bulteau A. L.
- Burcham P. C.
- Caito S.
- Cajone F.
- Calamini B.
- Calderwood S. K.
- Carbone D. L.
- Carbone D. L.
- Casini A.
- Chadli A.
- Chan H. Y.
- Chao P. L.
- Chapman A. L.
- Claiborne A.
- Clay C. E.
- Codreanu S. G.
- Cohen E.
- Conde R.
- Conde R.
- Connor R. E.
- Cotto J.
- Craig E. A.
- Craig E. A.
- Csermely P.
- Dai C.
- Davies M. J.
- Dickinson B. C.
- Dinkova-Kostova A. T.
- Dinkova-Kostova A. T.
- D’Autreaux B.
- Evgrafov O. V.
- Fawcett T. W.
- Gan N.
- Gidalevitz T.
- Gidalevitz T.
- Guettouche T.
- Guo Y.
- Harrison C. J.
- Hartl F. U.
- Hartl F. U.
- Hermawan A.
- Heydari A. R.
- Hieronymus H.
- Hietakangas V.
- Hietakangas V.
- Hilgarth R. S.
- Holbrook N. J.
- Holmberg C. I.
- Homma S.
- Hong Y.
- Hsu A. L.
- Hur W.
- Hyun D. H.
- Jacobs A. T.
- Jakobsen B. K.
- Jakobsen B. K.
- James D. West
- Jolly C.
- Jurivich D. A.
- Kaarniranta K.
- Kamada M.
- Kanfi Y.
- Kansanen E.
- Katsuno M.
- Kevin A. Morano
- Khong T.
- Kim D.
- Klaic L.
- Kline M. P.
- Knauf U.
- Kon M.
- Kondo M.
- Lawson B.
- Le Moan N.
- Lee P.
- Leonard S. E.
- Levinson W.
- Liebler D. C.
- Lindquist S.
- Liu H.
- Liu Q.
- Liu X. Y.
- Liu Y.
- Liu Z.
- Locke M.
- Lu M.
- Lu M.
- Mager W. H.
- Manalo D. J.
- Manalo D. J.
- Marnett L. J.
- Marozkina N. V.
- Mayya V.
- McMillan D. R.
- Mikuriya T.
- Morano K. A.
- Morano K. A.
- Mori K.
- Mori-Iwamoto S.
- Morimoto R. I.
- Morimoto R. I.
- Morley J. F.
- Morley J. F.
- Morrow G.
- Morrow G.
- Moulis J. M.
- Mu T. W.
- Mu T. W.
- Mullally J. E.
- Murata M.
- Nadkarni D. V.
- Nakai A.
- Neckers L.
- Neef D. W.
- Neef D. W.
- Nemani R.
- Nollen E. A.
- Olsen J. V.
- Olsen J. V.
- Ong D. S.
- Osburn W. O.
- Otaka M.
- Pattaramanon N.
- Paulsen C. E.
- Perdrizet G. A.
- Perez-Sala D.
- Perisic O.
- Peteranderl R.
- Peteranderl R.
- Powers E. T.
- Rabindran S. K.
- Rabindran S. K.
- Rahmani M.
- Rand J. D.
- Rossi A.
- Rudolph T. K.
- Salomons F. A.
- Sanchez Y.
- Sanchez Y.
- Sanchez-Gomez F. J.
- Santagata S.
- Santagata S.
- Santoro M. G.
- Sarge K. D.
- Schett G.
- Schlesinger M. J.
- Schulte T. W.
- Sharma S. K.
- Shi Y.
- Shi Y.
- Shibata T.
- Siegel S. J.
- Singh O. V.
- Soncin F.
- Soto C.
- Sreeramulu S.
- Steinkraus K. A.
- Stepanova L.
- Stone D. E.
- Sykiotis G. P.
- Taipale M.
- Tanabe M.
- Tang D.
- Thompson C. A.
- Trott A.
- Uchida K.
- Vargas-Roig L. M.
- Vila A.
- Voellmy R.
- Walter P.
- Wandinger S. K.
- Wang X.
- Wang Y.
- Weerapana E.
- West J. D.
- West J. D.
- West J. D.
- West J. D.
- Westerheide S. D.
- Westerheide S. D.
- Westerheide S. D.
- Westwood J. T.
- Wilde I. B.
- Winter J.
- Winterbourn C. C.
- Woods C. G.
- Wu C.
- Wu J.
- Xia W.
- Yang H.
- Yang H.
- Yanyu Wang
- Yasuda H.
- Zhang Q.
- Zhang Y.
- Zhang Y.
- Zhong M.
- Zou J.
- Zou J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study