Key Performance Indicators for Sustainable Urban Development: Case Study Approach

Abstract Built environment energy efficiency improvement at the urban scale plays a key role to reduce the detrimental environmental impacts. However, the design and implementation of sustainable development scenarios is a complex process involving a large number of decision criteria and actors. An on-going Interreg project, "CesbaMED", emphasizes to employ a common sustainability assessment framework at the urban scale, which is a set of eight regional assessment tools, named CESBA MED SNTool. This tool is an innovative decision-making process, which supports the development of energy efficiency plans for building stock in the context of their surrounding neighbourhoods. Moreover, this tool produces the MED Passport, which compares the sustainability performances of buildings and neighbourhoods. This study aims at presenting the on-going research activities with a specific focus on the selection of the set of relevant Key Performance Indicators (KPIs) among the indicators of CesbaMED project for the case study of the city of Turin (Italy), based on stakeholders' preferences. A workshop was organized to select the criteria and to assign the stakeholders' preferences using the "Delphi" survey method. This method is used in order to investigate the stakeholders' perspectives on the impact of each indicator on the different future sustainable scenarios. The results show that the stakeholders decided to remove and modify some KPIs for the specific case study of Turin with respect to its particularities

Circular economy and the role of universities in urban regeneration: the case of Ortigia, Syracuse

Regeneration processes activate stable regimes of interaction and interdependence among the architectural, economic, cultural and social sub-systems in settlements. The thesis of this paper is that in order to progress towards sustainable and inclusive cities, urban governance should widen the decision-making arena, promoting virtuous circular dynamics based on knowledge transfer, strategic decision making and stakeholders’ engagement. The historic urban landscape is a privileged la b for this purpose. The paper adapts the Triple-Helix model of knowledge-industry-government relationships to interpret the unexpected regimes of interaction between Local Authority and Cultural Heritage Assets triggered in the late 90es by the establishment of a knowledge provider such as a Faculty of Architecture in the highly degraded heritage context of the city of Syracuse, Italy. Following this approach, the authors explain the urban regeneration happened over the last 20 years in the port city of Syracuse, based on knowledge sharing and resources’ protection that promoted processes of social engagement and institutional empowerment for both new residents and entrepreneur

COVID-19 and Type 1 Diabetes: Concerns and Challenges

Due to the current COVID-19 pandemic, worldwide population's lifestyle has changed dramatically, causing psychosocialconsequences. Patients presenting a preexisting chronic condition, as Type 1 Diabetes (T1D), are the ones suffering the most from this situation. Moreover, people affected by diabetes are the ones with the worst prognosis, if infected by SARS-CoV-2. We analyzed why patients with T1D were poorly represented between the subjects hospitalized for COVID-19 and why the cases of diabetic ketoacidosis (DKA) were fewerand more severe compared with the past years. Furthermore, literature has showed howpatients of all ages with T1D did not experience a deterioration in their glucose control throughout the lockdown. Among other causes, this is also due tothe surging use of telemedicine. Finally, we tried to understand how the coronavirus tropism for endocrine tissues could influence the future epidemiology of T1D, focusing on the effects they have on pancreatic beta-cells

Hazelnut Skin in Ewes’ Diet: Effects on Colostrum Immunoglobulin G and Passive Transfer of Immunity to the Lambs

SIMPLE SUMMARY: A ewe’s diet in the last period of gestation can modify the immunoglobulin G composition of the colostrum and consequently the health status of lambs. This study aims to determine the role of hazelnut skin on the immunological colostrum quality and the passive immunity transfer in newborns. The results show that hazelnut skin supplementation in the diet positively affects the immunoglobulin G composition of the colostrum. The experimental trial underlines that the use of by-products in livestock feeding provides a paramount opportunity to create a circular economy system with health benefit on farmed animals. ABSTRACT: Passive immunity transfer has a pivotal role in newborn lambs, where the colostrum represents the primary source of immunoglobulins. This study hypothesized that the high content in polyphenolic compounds, mono- and poly-unsaturated fatty acids, and vitamin E of hazelnut skin affects blood and colostrum immunoglobulin G (IgG) concentration and related gamma-glutamyl-transferase (GGT) and lactate dehydrogenase (LDH) levels in sheep and their lambs. In the last 45 days of pregnancy, ewes were divided into a control (CTR) and a hazelnut skin supplemented group (HZN). Blood and colostrum were collected from ewes and lambs before the first suckling, at 24 and 48 h after birth, then IgG concentration, GGT and LDH activity levels were measured. IgG concentration in the colostrum and in lamb’s serum were significantly greater in HZN than CTR. No significant difference was detected for ewe’s blood. A significant positive correlation was found between IgG and GGT in lambs’ serum and colostrum, between IgG and LDH, as well as between GGT and LDH in lambs’ serum and colostrum. Our results suggest that hazelnut skin supplementation influences IgG colostrum concentration, with improved immune passive transfer to the suckling lambs. The transfer of maternal derived immune factors is confirmed by the GGT and LDH enzyme activity levels

Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers.

Abstract Exosomes-secreted microRNAs play an important role in metastatic spread. During this process breast cancer cells acquire the ability to transmigrate through blood vessels by inducing changes in the endothelial barrier. We focused on miR-939 that is predicted to target VE-cadherin, a component of adherens junction involved in vessel permeability. By in silico analysis miR-939 was found highly expressed in the basal-like tumor subtypes and in our cohort of 63 triple-negative breast cancers (TNBCs) its expression significantly interacted with lymph node status in predicting disease-free survival probability. We demonstrated, in vitro , that miR-939 directly targets VE-cadherin leading to an increase in HUVECs monolayer permeability. MDA-MB-231 cells transfected with a miR-939 mimic, released miR-939 in exosomes that, once internalized in endothelial cells, favored trans-endothelial migration of MDA-MB-231-GFP cells by the disruption of the endothelial barrier. Notably, when up taken in endothelial cells exosomes caused VE-cadherin down-regulation specifically through miR-939 as we demonstrated by inhibiting miR-939 expression in exosomes-releasing TNBC cells. Together, our data indentify an extracellular pro-tumorigenic role for tumor-derived, exosome-associated miR-939 that can explain its association with worse prognosis in TNBCs

Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies

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Dental Ritual Mutilations and Forensic Odontologist Practice: a Review of the Literature

Uvod: Etnička sakaćenja imaju antropološko značenje, kako u suvremenom tako i u nekadašnjem ljudskom ponašanju, ovisno o geografskim, religioznim i kulturnim čimbenicima koji znatno mogu pomoći forenzičnom stomatologu u postupku izrade dentalnog profila. Sakaćenje zuba i ukrasi na njima bili su, i još uvijek jesu, uobičajeni među mnogim etničkim skupinama i kulturama. Kroz povijest ljudskoga roda zdravlje zuba bilo je simbol mladosti, ljepote i snage, ali može imati i druga značenja. Sakaćenje zuba obilježje je mnogih nestalih kultura i prakticiralo se uglavnom tijekom religijskih rituala, u estetske svrhe i kao simbol pripadnosti određenoj socijalnoj skupini. No slični običaji i danas su uobičajeni u nekim područjima diljem svijeta. Materijali i metode: Članak je zapravo sustavni pregled literature o ritualnom sakaćenju zuba iz ranih 1960-ih, a uključeni su i podatci s PubMeda, Scopusa i Google Scolara. Istaraživanje je namjerno ograničeno na ritualno sakaćenje koje se može definirati kao bilo koje nepovratno narušavanje integriteta ljudskoga organizma učinjeno u ritualne svrhe i bez namjere liječenja. Zato su isključeni svi slučajevi pojedinačnih ili višestrukih samovađenja zuba učinjenih iz psihotičnih razloga te oralno sakaćenje djece jer se takva praksa u nekim etničkim skupinama smatra terapijskom. Zaključak: Spoznaje o promjenama na zubima nakon oralnoga sakaćenja važne su pri identifikaciji živih ili umrlih osoba, ili čak ljudskih ostataka jer odaju odgovarajuće informacije o etničkom i kulturološkom podrijetlu subjekta. U ovom članku navedena su i neka medicinskopravna stajališta o sakaćenju zuba, a namijenjena su doktorima dentalne medicine.Background: Ethnic mutilations have a social and anthropological significance both in contemporary and past human behavior, influenced by geographic, religious and cultural factors which can greatly help forensic odontologist’s practice in dental profiling process. ental ritual mutilations and dental decorations were - and still are - practiced among many ethnic groups and cultures. Throughout the history of humanity, having healthy teeth has a symbolic meaning of youth, beauty and strength, but it can also have other meanings. Dental ritual mutilations were documented in many cultures in the past and were practiced mainly for religious rituals purposes, for esthetic reasons and because they represented a symbol of status or of belonging to a particular social group. Similar rituals are still performed. Material and Method: The present paper is a systematic review of the literature reporting on dental ritual mutilations from the early 1960s and is included in Pubmed, Scopus and Googlescholar. The research was deliberately limited only to the ritual mutilations, which can be defined as “any irreversible impairment of the integrity of the human organism, made with a ritual purpose and without any curative aim”. Therefore all the articles dealing with single or multiple dental self extractions of psychotic origins were excluded, as well as the infant oral mutilations, since the practice is deemed to have therapeutical effects among ethnic groups dedited to this practice. Conclusions: The knowledge of dental alteration due to oral mutilations can be a powerful tool for the identification procedures of living or dead persons or even in human remains especially providing relevant information about the ethnic origins and the cultural background of a subject. Some medical legal issues for the odontologist about dental mutilation are also addressed in the paper

The cypsela (achene) of Echinacea purpurea as a diffusion unit of a community of microorganisms

Echinacea purpurea is a plant cultivated worldwide for its pharmaceutical properties, mainly related to the stimulation of the immune system in the treatment of respiratory infections. The cypselas (fruits) of E. purpurea were examined in order to investigate the presence, localization and potential function(s) of endophytic microorganisms. Electron and confocal microscopy observations showed that three different components of microorganisms were associated to cypselas of E. purpurea: (i) one endocellular bacterial component in the cotyledons, enclosed within the host membrane; (ii) another more generic bacterial component adhering to the external side of the perianth; and (iii) a fungal component inside the porous layer of the perianth, the woody and porous modified residual of the flower, in the form of numerous hyphae able to cross the wall between adjacent cells. Isolated bacteria were affiliated to the genera Paenibacillus, Pantoea, and Sanguibacter. Plate tests showed a general resistance to six different antibiotics and also to an antimicrobial-producing Rheinheimera sp. test strain. Finally, microbiome-deprived E. purpurea seeds showed a reduced ability to germinate, suggesting an active role of the microbiome in the plant vitality. Our results suggest that the endophytic bacterial community of E. purpurea, previously found in roots and stem/leaves, might be already carried at the seed stage, hosted by the cotyledons. A further microbial fungal component is transported together with the seed in the perianth of the cypsela, whose remarkable structure may be considered as an adaptation for fungal transportation, and could influence the capability of the seed to germinate in the soil

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented