Building a Sustainable Innovation Ecosystem in Universities for Ideation and Entrepreneurial Competence: The University of Lagos Experience

What is new? Universities in the global south particularly in sub-Saharan African countries have not impacted greatly on their host communities as research efforts in these universities are not linked to innovation addressing societal challenges. What was the approach? The University of Lagos (UNILAG), recognizing that a robust innovation ecosystem is central to building capacity in the innovation space for unleashing the creative potentials of both faculty and students beyond traditional teaching and research, activated three units to drive innovation-related activities in the university. This article presents critical discussions on the University of Lagos’s experience in driving innovation through novel institutional frameworks facilitated by the Research Management Office, the Innovation & Technology Management Office, and the Entrepreneurship & Skills Development Centre. The article also presents challenges encountered in the process and strategies employed to successfully navigate through the challenges, lessons learned, successes recorded in patents and intellectual property management, as well as future directions for greater impact. What is the academic impact? The paper makes recommendations for sustainability and for the implementation of efficient strategies in newly established units seeking to strategically drive innovation-related activities. What is the wider impact? Practical implications of the UNILAG’s experience for Research and management practitioners in developing countries are articulated

Fostering social connections through internet use: visually impaired older people’s use of computer mediated communications

In today’s ICT dynamic society, questions continue on how internet use affects social relationships and well being. By building upon past work and conceptualising visually impaired older adults as a distinct user group, this research explored the perceptions of visually impaired older people concerning how they build and maintain social ties via Computer Mediated Communication (CMC). The research attempts to create an understanding of how internet use could be of benefit to visually impaired older adults and what implications it has for their social well being. The study employed tools of ethnography [observations in an internet café specifically for visually impaired people and semi structured interviews]. One to one and focus group interviews were conducted with 23 visually impaired older adults between the ages of 60 87 years. All participants were registered visually impaired members of a Voluntary organisation in Newcastle, UK. Findings show that participants mainly perceived the internet as a means to establish and maintain social relationships rather than a substitute for social contacts in the face of myriad challenges with socialisation offline. It also enabled them to challenge popular stereotypes about older people and use of new technologies. Many participants regarded internet use as a means to enhance social connectedness and overcome feeling isolated. Findings showed how internet use fits into the communication styles of visually impaired older people and enable them to cope with the challenges of vision loss. Some participants regarded the absence of visual cues in CMC as a communication advantage which afforded them a platform to socialise with others on an equal footing. The implication of findings for existing theoretical concepts of CMC and the need for a more inclusive theoretical stance which integrates the position of visually impaired users were discussed. The study concludes that the internet is a vital tool for social integration of visually impaired groups. It has potential for positive impact on their well being if accessibility is further enhanced

Government Intervention and Support on Smes Firm Performance

The small and medium enterprise firms are renowned for improving the nation’s economy through the provision of job opportunities for its populace, improving the financial and investment status of the countries and provision of innovative products that meets the need of the people. SMEs are key players in the economy, through sustainable development goals (SDGs) enabling them to thrive in the open business environment and actively applying the digital transformation, promoting inclusive and sustainable industrialization should be the core of any country government. This research is designed to explore the influence of government intervention and support on enterprise performance and growth in five business sectors- Hospitality, Education, Health care, Bottled Water Production and Transport and Logistics organizations. The research paper had a descriptive research design with a randomly selected sample size of one hundred and ninety- seven respondents.The research hypotheses were tested using (Factor Analysis and Ordinal Logistic Regression Analysis) with Statistical Packages for Social Science (SPSS) version 25. The results of the study reveal that government intervention policies and intervention programmes when instituted will promote the growth of business firms in Nigeria. Also identified are relevant recommendations that serve as motivation for policy administrators, entrepreneurs, and business managers to ensure that relevant intervention programme is adopted to boost performance and growth of the SME sector in Nigeria

Ethical Issues and Performance of Nigerian Insurance Companies

This study investigated Ethical Issues in Business and Performance of Nigerian Insurance Companies. The specific objective was to establish the effect of business ethics variables on the performance of Nigeria Insurance Companies. Data collection was with the aid of a structured questionnaire administered on 411 employees of insurance companies in Nigeria in the 10 selected organization. A total of 390 responses were processed for analysis. . Statistical techniques such as descriptive and inferential statistics (regression and correlation) were applied in the analysis. It was observed that there exists strong relationship between business ethics and performance of Nigerian Insurance companies. Workforce diversity was found to have negative connection with Nigerian Insurance Companies’ Performance. It was revealed that strong positive relationship exists between organizational ethical code and Nigerian Insurance Companies’ Performance and environmental regulatory compliance impact the performance of Nigerian Insurance Companies negatively. While all the independent variables were found to be statistically significant in predicting the Nigerian Insurance Companies’ Performance. It was concluded that ethical issues significantly impact Nigerian Insurance companies’ performance. To enhance resource utilization and performance, it was suggested that Nigerian Insurance company may consider putting ethical issues as priority in all dealings and guide it jealously in order to wax stronger in the industry

Innovative Behaviour and Firm’s Performance in the Nigerian Manufacturing Sector

The paper examined innovative behaviour and firm’s performance in the Nigerian manufacturing industry. Relevant literatures have emphasized the need to make a strong relevance for innovativeness to act as a catalyst for innovation to occur in the firm. While there has been significant research evidence on the conceptualization of innovation, more of the studies have focused on the descriptive nature of innovation. The population of the study was the staff in the selected company and questionnaire was distributed on the company’s sample. The study employed the univariate analysis of variance (ANOVA) to ascertain the statistical significance and the level to which innovativeness give rise to variation in firm’s performance in the selected organization. The study emphasized the immense benefit manufacturing firms and industrial policy makers will make towards the attainment of innovativeness to contribute adequately to the economic development of the nation and the social well-being of the citizens

Models for Predicting Time to Sputum Conversion Among Multi-Drug Resistant Tuberculosis Patients in Lagos, South–West Nigeria

Background: Multi-drug resistant tuberculosis (MDR-TB) develops due to problems such as irregular drug supply, poor drug quality, inappropriate prescription, and poor adherence to treatment. These factors allow the development and subsequent transmission of resistant strains of the pathogen. However, due to the chronic nature of MDR-TB, cure models allow us to investigate the covariates that are associated with the long-term effects of time-to-sputum conversion among multi-drug resistant (MDR-TB) tuberculosis individuals. Therefore, this study was designed to develop suitable cure models that can predict time to sputum conversion among MDR-TB patients.Methods: A retrospective clinic-based cohort study was conducted on 413 records of patients who were diagnosed of MDR-TB and met inclusion criteria from April 2012 to October 2016 at the Infectious Disease Hospital, Lagos. The main outcome measure (time-to-sputum conversion) was the time from the date of MDR-TB treatment to the date of specimen collection for the first of two consecutive negative smear and culture taken 30 days apart. The predictor variables of interest include: demographic (age, gender and marital status) and clinical (registration group, number of drugs resistant to at treatment initiation, HIV status, diabetes status, and adherence with medication) characteristics. Kaplan-Meier estimates of a detailed survivorship pattern among the patients were examined using Cox regression models. Mixture Cox cure models were fitted to the main outcome variable using Log-normal, Log-logistic and Weibull models as alternatives to the violation of Proportional Hazard (PH) assumption. Akaike Information Criterion (AIC) was used for models comparison based on different distributions, while the effect of predictors of time to sputum conversion was reported as Hazard Ratio (HR) at α0.05.Results: Age was 36.8 ± 12.7 years, 60.8% were male and 67.6% were married. Majority of the patients (58.4%) converted to sputum negatives. Patients who were resistant to two drugs at treatment initiation had 39% rate of conversion than those resistant to at least three drugs [HR: 1.39; CI: 0.98, 1.98]. The likelihood of sputum conversion time was shorter among non-diabetic patients compared to diabetics [HR: 0.55; CI: 0.24, 0.85]. The overall median time for sputum conversion was 5.5 (IQR: 1.5–11.5). In the cure model, resistance to more drugs at the time of initiation was significantly associated with a longer time to sputum culture conversion for Log normal Cox mixture [2.06 (1.36–3.47)]; Log-logistic Cox mixture cure [2.56(1.85–4.09)]; and Weibull Cox mixture [2.81(1.94–4.19)]. Diabetic patients had a significantly higher sputum conversion rate compared to non-diabetics; Log-normal Cox mixture [2.03(1.17–3.58)]; Log-logistic Cox mixture cure [2.11(1.25–3.82)]; and Weibull Cox mixture [2.02(1.17–3.34)]. However, Log-normal PH model gave the best fit and provided the fitness statistics [(−2LogL: 519.84); (AIC: 1053.68); (BIC: 1078.04)]. The best fitting Log-normal PH model was Y = 1.00X1+2.06X2+0.98X3+2.03X4+ε where Y is time to sputum conversion and Xs are age, number of drugs, adherence, and diabetes status.Conclusion: The models confirmed the presence of some factors related with sputum conversion time in Nigeria. The quantum of drugs resistant at treatment initiation and diabetes status would aid the clinicians in predicting the rate of sputum conversion of patients

Exploring barriers to guideline implementation for prescription of surgical antibiotic prophylaxis in Nigeria.

Background: In Nigeria, the prescription of surgical antibiotic prophylaxis for prevention of surgical site infection tends to be driven by local policy rather than by published guidelines (e.g. WHO and Sanford). Objectives: To triangulate three datasets and understand key barriers to implementation using a behavioural science framework. Methods: Surgeons (N = 94) from three teaching hospitals in Nigeria participated in an online survey and in focus group discussions about barriers to implementation. The theoretical domains framework (TDF) was used to structure question items and interview schedules. A subgroup (N = 20) piloted a gamified decision support app over the course of 6 months and reported barriers at the point of care. Results: Knowledge of guidelines and intention to implement them in practice was high. Key barriers to implementation were related to environmental context and resources and concern over potential consequences of implementing recommendations within the Nigerian context applicable for similar settings in low-to-middle-income countries. Conclusions: The environmental context and limited resource setting of Nigerian hospitals currently presents a significant barrier to implementation of WHO and Sanford guidelines. Research and data collected from the local context must directly inform the writing of future international guidelines to increase rates of implementation

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56 604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100 000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100 000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100 000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100 000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100 000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation

Internet use: Perceptions and experiences of visually impaired older adults

Many older people are increasingly using the internet. This study investigated the experiences of visually impaired older people on internet use and explored how it fits into their lives. 20 visually impaired older people aged 60 years and over were recruited from a voluntary organisation for blind people. Qualitative interviews were conducted with all participants to investigate how they perceive the relevance of internet use to their daily lives. Findings suggest that the internet not only has potential to promote their ability to perform daily tasks, cope with vision impairment and feel socially included. However, the rapid pace of technological advancement is feared as a development that could further widen the digital divide if they are not carried along by addressing barriers to their internet