Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study:Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

To improve the ‘personalized-medicine ’ approach to the treatment of depression, we need to identify biomarkers that, assessed before starting treatment, predict future response to antidepressants (‘predictors’), as well as biomarkers that are targeted by antidepressants and change longitudinally during the treatment (‘targets’). In this study, we tested the leukocyte mRNA expression levels of gene