EFFICACY OF MRUDWEEKADI KASHAYA AND KALYANAKA GHRIT NASYA IN THE TREATMENT OF ALCOHOLIC ADDICTION (MADATYAYA)

Madatyaya (Alcohol Withdrawal Syndrome) is a crucial problem in India, many people lose their life due to it. Madya (Alcohol) is when taken judiciously act like Nector but when used without restriction act like poison and creates symptoms of Madatyaya (Alcohol withdrawal Syndrome). It ruins our social mental and economic status. As a doctor it is our responsibility to help such alcohol addicts by counselling and treating them to recover from this addiction. It was with this intention that the disease Madatyaya has been chosen for the study.A study was conducted to access efficacy of ‘‘Mrudvikadi Kashayam & Kalyanaka Ghrita Nasyam’’. 50 patients of Madatyaya were selected in control group and 50 patients in trial group by random selection method. Control group was not given any medicine; however they were observed for 42 days for all parameters. Trial group patients received medications in the form of Gandharva Haritaki for the first 6 days followed by ‘Mrudvikadi Kashayam panartha’ in the dose of 80ml with Jala (water) in 2 divided dose, morning and evening after food for the duration of 42 days and Kalayanakaa ghrita Pratimarsha Nasya 6 drops in each nostril from day 7 for 42 days.  Gradation scale was used for the purpose of case taking; however at the time of statistical analysis Wileoxan test, Mann-Whitney test, Paired t-test, Unpaired t-test were used. It revealed that ‘Mrudvikadi Kashayam & Kalyanaka Ghrita Nasya’ is effective in Madatyaya. It significantly reduces the symptoms. Agnimandya, Aruchi, Hrullas, Chardi, Daha, Murcha, Gaurav, Kasa, Tandra, Atisweda, Daurbalya and Nidranasha. Both the groups showed better efficacy in alleviation of symptoms of Pralap, Parshwashoola, Trishna and Shirokampa.‘Mrudvikadi Kashayam’ is Balya, Rasayana agni deepana and srotoshodhaka and Pachana,  and the utility of Kalyanaka ghrita indicates its action on Manovahastrotas by empowering it. ‘Mrudvikadi Kashayam’ enhances the nutritional status of such alcoholic patients, also appetite and metabolism is increased due to its Deepan karma, which directly affects the Hb level in patients. As Pippali, Yashtimadhu, possesses Vishghna property, ‘Mrudvikadi Kashayam’ de-toxified the toxic effects of Madya on Liver thus helpful in lowering LFT values. In Madatyaya due to Madya along with Agni dhushti, Srotodushti is also a pathological change. Hence, to treat that Mrudweekadi Kashaya and Kalyanaka Ghrita was selected.

Seismic assesement of masonry infill RC framed building with soft ground floor

Construction of multistoried buildings with open ground floor is a common trend of urbanization of cities of many parts of many countries. Social and functional need to provide parking space at ground level outweighs the seismic vulnerability of such buildings. Generally these buildings are designed as RC framed structures without regards to structural action of masonry infill walls present in the upper floors. In the present paper an investigation has been made to study the behavior of RC frames with various arrangement of infill when subjected to dynamic earthquake loading. Result of bare and infill frame are compared and somem conclusions are made in view of IS -1893(2002) code

Atorvastatin calcium loaded chitosan nanoparticles: in vitro evaluation and in vivo pharmacokinetic studies in rabbits

In this study, we prepared atorvastatin calcium (AVST) loaded chitosan nanoparticles to improve the oral bioavailability of the drug. Nanoparticles were prepared by solvent evaporation technique and evaluated for its particle size, entrapment efficiency, zeta potential, in vitro release and surface morphology by scanning electron microscopy (SEM). In addition, the pharmacokinetics of AVST from the optimized formulation (FT5) was compared with marketed immediate release formulation (Atorva(r)) in rabbits. Particle size of prepared nanoparticles was ranged between 179.3 ± 7.12 to 256.8 ± 8.24 nm with a low polydispersity index (PI) value. Zeta potential study showed that the particles are stable with positive values between 13.03 ± 0.32 to 46.90 ± 0.49 mV. FT-IR studies confirmed the absence of incompatibility of AVST with excipient used in the formulations. In vitro release study showed that the drug release was sustained for 48 h. Results of pharmacokinetics study showed significant changes in the pharmacokinetic parameter (2.2 fold increase in AUC) of the optimized formulation as compared to marketed formulation (Atorva(r)). Thus, the developed nanoparticles evidenced the improvement of oral bioavailability of AVST in rabbit model.</p

Search for Tensor, Vector, and Scalar Polarizations in the Stochastic Gravitational-Wave Background

The detection of gravitational waves with Advanced LIGO and Advanced Virgo has enabled novel tests of general relativity, including direct study of the polarization of gravitational waves. While general relativity allows for only two tensor gravitational-wave polarizations, general metric theories can additionally predict two vector and two scalar polarizations. The polarization of gravitational waves is encoded in the spectral shape of the stochastic gravitational-wave background, formed by the superposition of cosmological and individually unresolved astrophysical sources. Using data recorded by Advanced LIGO during its first observing run, we search for a stochastic background of generically polarized gravitational waves. We find no evidence for a background of any polarization, and place the first direct bounds on the contributions of vector and scalar polarizations to the stochastic background. Under log-uniform priors for the energy in each polarization, we limit the energy densities of tensor, vector, and scalar modes at 95% credibility to Ω0T<5.58×10-8, Ω0V<6.35×10-8, and Ω0S<1.08×10-7 at a reference frequency f0=25 Hz. © 2018 American Physical Society

Erratum: "A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo" (2021, ApJ, 909, 218)

[no abstract available