Quantitative UV-spectrophotometry estimation of risperidone using hydrotropic solubilization phenomenon

The aim of present study was to develop simple and economical UV- pectrophotometric method for estimation of Risperidone using Area Under Curve (AUC) technique with the application of hydrotropic solubilisation phenomenon. Aqueous urea solution (30% v/v ) was used as hydrotropic agent for solubilising risperidone. The method is based upon integration of area under curve for analysis of risperidone in the wavelength range of 265.0 - 287.40 nm. The drug followed linearity in the concentration range of 4 - 24 g/mL with correlation coefficient value r 2 > 0.99. Proposed method was validated for accuracy, precision, repeatability and ruggedness as per ICH guidelines. The proposed method was applied for qualitative and quantitative estimation of risperidone in pharmaceutical formulation and results were found in good agreement with the label claimed. This developed method can be used for routine analysis of Risperidone in bulk and tablets