How are health, burnout, and satisfactory levels affected by the use of mindfulness therapies among the nursing population?

Abstract Question: How are health, burnout, and satisfactory levels affected by the use of mindfulness therapies among the nursing population? Background: Burnout has increased significantly in the United States and around the world since the COVID-19 pandemic, and it is even more pronounced among healthcare professionals. Significance: The percentage of burnout increased from 20%-40% to over 60% in healthcare professionals, the spring of 2021. This can lead to unsafe practices: human errors, low satisfaction rates, and a negative environment. Purpose: This project will see if mindfulness approaches combat poor health, burnout, and low satisfactory rates in nurses, leading to the overall improvement of the nursing field. Literature review: Numerous practices that help to calm the body and mind are incorporated into the exercise of yoga. Yoga has been demonstrated to reduce stress and anxiety, which in turn decreases burnout. Additionally, several studies showed mindfulness meditation can improve resilience while lowering stress, anxiety, and burnout. Methods: Within 6 months, 60 nurses will take part in this study. Randomly, 20 nurses will be placed in a control group that receives no interventions, the other 20 nurses will be placed in the group that receives yoga as an intervention, and lastly, the last 20 will be placed in the mindfulness meditation group. Their progress will be measured in bi-monthly intervals. Evaluation: The use of surveys, questionnaires, and scales will be used to determine the effectiveness of methods pre- and post- intervention. The use of graphs will also help analyze the interventions and which is more effective. Keywords: Anxiety, Burnout, Healthcare, Mindfulness, Nursing, Stress, and Yog

Chloride anion transporters inhibit growth of methicillin-resistant: Staphylococcus aureus (MRSA) in vitro

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(−) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl– transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro.<br/

Sustainability of the Underground Water System

With more than 250 million tons of trash created in the United States each year, underground water systems are at risk for becoming contaminated with toxins that can cause serious health problems. This video discusses the adverse effects of improperly maintained water systems as well as the laws that have been enacted to protect our country’s water supply

Investigating the Role of Oncogenic KRAS G12 Mutations in Cell Signalling

Cancer is a multistep process reflecting genetic alterations that drive progressive transformation of normal cells into highly proliferative malignant cells. Deregulation of cellular signalling is one of the key traits in cancer, allowing cells to breach anticancer defence mechanisms. The most frequently mutated oncogene in cancer is KRAS, encoding a small GTPase protein involved in controlling the activity of critical signalling pathways that regulate normal cellular proliferation, such as the PI3K and ERK pathways. The prevalence of different codon substitutions in the KRAS gene varies in different tissues. There is emerging evidence supporting the notion that different codon substitutions may trigger different biological effects. We hypothesise that different codon substitutions in KRAS can trigger different feedbacks and signalling dynamics that may result in varying fitness advantages in different tissues. I use quantitative Western blotting and Modular Response Analysis with KRAS isogenic cell lines to characterise how KRAS substitutions at codon G12 perturb the topology and dynamics of the ERK signalling network as a first step to test this hypothesis. My work has identified two mutant-specific interactions in the ERK pathway: a MEK to RAF inhibition seen strongest in G12A, G12C and G12D cells, and a RAF to ERK activation (or loss of inhibition) seen in all mutants compared to WT. Antibody array data suggests the potential role of JNK and TYK2 in mediating these interactions, respectively, and thus my work has provided preliminary, albeit testable, hypotheses for elucidating the possible mechanisms responsible for this rewiring of the ERK pathway. My work has also identified the presence of a second BRAF form present only in the mutants with the strongest MEK to RAF inhibition. It appears this KRAS-mutant specific BRAF form is most likely a splice variant that has enhanced dimerisation capabilities with CRAF. RAF dimerisation is one mechanism via which RAF inhibitors fail to be effective in treating KRAS mutant cancers. This exemplifies the importance of characterising the identity and role of this BRAF form, as it may have implications on development of mutant-specific therapies for KRAS-driven cancers. ERK pathway activation can also regulate the transcription of many downstream targets. I have attempted to characterise KRAS-dependent gene expression changes with RNA sequencing data, with the aim of understanding key differences between mutant and WT KRAS cells and to also understand how the gene expression profiles change over time during the very early steps in oncogenesis. Preliminary data suggests mutant-specific differential gene transcription that may be linked to the RAF inhibition via MEK and/or the second BRAF form. My work currently does not explain the specific mechanisms behind the interactions identified with MRA, however, it does lay down the foundation and provides hypotheses that can be tested in the lab. Gaining mechanistic insight into the pathogenicity of cancer driver mutations and their differential role in different tissues is of fundamental importance to understand how different mutations shape the evolution of cancer clones during carcinogenesis and to design optimal targeted therapeutic strategies

The effect of early life adversity on basolateral amygdala projections to the prefrontal cortex in male and female rats during development

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Sacroiliac joint: A review

Sacroiliac joint (SIJ) pain is one of the common but underdiagnosed source of mechanical low back pain. The incidence is estimated to be in the range of 15%–30% in patients with nonradicular low back pain. The signs and symptoms of SIJ pain mimic pain arising from other causes of low back pain. There is no single symptom or physical examination finding that can firmly diagnose SIJ as a source of patient's pain. There is good evidence suggesting that a combination of three or more positive provocative tests strongly suggests SIJ dysfunction. Intra-articular injection with local anesthetic is considered the gold standard for diagnosis of SIJ pain. Many treatment modalities are available for SIJ pain, ranging from conservative management to surgical interventions. This review article covers all the aspects of SIJ pain, with treatment section mainly covering evidence-based interventional procedures

An atypical case of postsurgical complex regional pain syndrome in a patient having nonhealing varicose venous ulcer treated by lumbar sympathectomy

Complex regional pain syndrome (CRPS) of the lower limb is a relatively uncommon entity as compared to CRPS of the upper extremity. Literature search has revealed only 2 retrospective case series and a single case report of lower extremity CRPS type I from 1975 to 2014 on Pubmed, isolated cases of CRPS type I of lower extremity have also been reported following knee surgeries and arthroscopies. This report presents a case of lower limb CRPS type I, following surgery for varicose vein ulcer. Pain was not relieved with medications. Diagnostic lumbar sympathectomy was done and patient had tremendous relief of pain following that, proving sympathetic mediated pain of the involved limb

Artemisin Combined Therapy in malaria patients: Do we need to search for more?

Introduction: Malaria is a vector borne disease highly prevalent in the topical developing countries. Two main species of plasmodium causing majority of diseases manifestations are P. Vivax and P. falciparum. The approach to antimalarial selection is determined based on the location of the patient. For treatment of uncomplicated P. falciparum malaria, according to WHO guidelines first line therapy mainly includes Artemisin Combined Therapy. Concerns about the emergence of resistance to artemisin derivatives have increased recently. The main aim of the present study is to investigate the effect of using a combination of intravenous artesunate along with oral doxycycline, as a novel ACT for Malarial infections – falciparum vs. vivax. Methodology: Prospective observational study was carried out at V S General Hospital in Ahmedabad, Gujarat, India. A full history of current illness was taken followed by examining the serial peripheral smear reports of the patients till the malarial parasites are not seen on two consecutive occasions. Samples were taken at least 6 hours apart by the capillary method and oral temperature was measured every 6 hours. We excluded other associated viral fevers such as dengue, pediatric age group (&lt;12 years) and Co-Morbid illnesses like hepatic or renal dysfunction. Data analysis was done using SPSS software version 20. Results: Student t test showed that PCT was significantly more in falciparum (mean= 74.53 hours) patients as compared to vivax patients (mean= 51.89 hours). (p&lt;0.001). Also duration of stay was significantly more in patients having falciparum (mean =3.63 days) as compared to patients having vivax (mean = 2.32 days) (p&lt;0.001) Multivariate analysis by linear regression showed that species of the parasite was the most significant independent predictor (B=12.552) of the time to parasite clearance and other significant variable was Grade of parasitemia at 0 hour (B= 12.798). We also found that patients with residual parasitemia was 83.78 %, 40.54% and 10.81% in vivax group whereas it was 100%, 88.15% and 46.05% in falciparum respectively at 24, 48 and 72 hours. Conclusion: The study shows that PCT and residual parasitemia is very high in falciparum patients as compared to previous reports of different studies and also as compared to vivax group patients. ACT resistance is a grave concern for falciparum and more studies should be done to understand pathophysiology and its prevalence in India. We strongly suggest that a continues monitoring needs to be implemented in health policy to understand the dynamicity of emerging resistanc

Socio-demographic, Epidemiological and Environmental Determinants of Acute Gastroenteritis in Western India

Introduction: An outbreak of acute gastroenteritis had occurred in Rajpara village of Bhavnagar district. The objective of this study was to find out the socio-demographic, epidemiological and environmental determinants of this outbreak. Methods: A case-control study was conducted in Rajpara village among 238 cases of acute gastroenteritis and an equal number of controls in January 2015. Multiple logistic regression was used for identifying the variables independently predicting acute gastroenteritis. Results: Upper socio-economic status, occupation requiring travel outside village, source of drinking water from well of ‘new’ Rajpara village, change in taste of water, use of chlorine tablets, travel outside village in last week, another family member affected with acute gastroenteritis, using common utensil for hand washing, hand washing before eating, ate food from outside in last week, having sanitary latrine at house, waste disposal in a common dump (instead of at house), waste accumulation around house and flies inside house were significantly associated with occurrence of acute gastroenteritis. On multiple logistic regression, change in taste of water (P&lt;0.001), waste disposal in a common dump (P=0.012), another family member been affected (P&lt;0.001), waste accumulation around house (P&lt;0.001), higher socio-economic status (P=0.002) and eating outside food (P=0.011) made a significant contribution to prediction. Conclusions: Socio-demographic factors (higher socio-economic status), epidemiological correlates (change in taste of water, another family member been affected with acute gastroenteritis and eating outside food) and environmental determinants (waste disposal in a common dump and waste accumulation around house) significantly determines the occurrence of cases of acute gastroenteritis. Keywords: case-control studies;diarrhea; epidemiologic determinants; gastroenteritis; social determinants of health. | PubMe