The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Causal Modelling of Heavy-Tailed Variables and Confounders with Application to River Flow

Confounding variables are a recurrent challenge for causal discovery and inference. In many situations, complex causal mechanisms only manifest themselves in extreme events, or take simpler forms in the extremes. Stimulated by data on extreme river flows and precipitation, we introduce a new causal discovery methodology for heavy-tailed variables that allows the use of a known potential confounder as a covariate and allows its effect to be almost entirely removed when the variables have comparable tails, and also decreases it sufficiently to enable correct causal inference when the confounder has a heavier tail. We introduce a new parametric estimator for the existing causal tail coefficient and a permutation test. Simulations show that the methods work well and the ideas are applied to the motivating dataset

The Effect of a Short Observational Record on the Statistics of Temperature Extremes

In June 2021, the Pacific Northwest experienced a heatwave that broke all previous records. Estimated return levels based on observations up to the year before the event suggested that reaching such high temperatures is not possible in today's climate. We here assess the suitability of the prevalent statistical approach by analyzing extreme temperature events in climate model large ensemble and synthetic extreme value data. We demonstrate that the method is subject to biases, as high return levels are generally underestimated and, correspondingly, the return period of low-likelihood heatwave events is overestimated, if the underlying extreme value distribution is derived from a short historical record. These biases have even increased in recent decades due to the emergence of a pronounced climate change signal. Furthermore, if the analysis is triggered by an extreme event, the implicit selection bias affects the likelihood assessment depending on whether the event is included in the modeling.ISSN:0094-8276ISSN:1944-800