Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action

peer reviewedIt has been shown previously that female mice homozygous for an alpha-fetoprotein (AFP) null allele are sterile as a result of anovulation, probably due to a defect in the hypothalamic-pituitary axis. Here we show that these female mice exhibit specific anomalies in the expression of numerous genes in the pituitary, including genes involved in the gonadotropin-releasing hormone pathway, which are underexpressed. In the hypothalamus, the gonadotropin-releasing hormone gene, Gnrh1, was also found to be down-regulated. However, pituitary gene expression could be normalized and fertility could be rescued by blocking prenatal estrogen synthesis using an aromatase inhibitor. These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation

Assignment of the rat Crebbp and Rxrip13 to the chromosome bands 10q12-21 and 10q24 respectively by in situ hybridization

Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Assignment of the hepatocyte nuclear factor 3 genes to rat chromosome bands 6q23-->q24 (alpha: Hnf3a), 3q41 (beta: Hnf3b) and 1q21-->q22 (gamma: Hnf3g) by in situ hybridization.

Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Assignment of the rat Crebbp and Rxrip13 genes to chromosome bands 10q12→q21 and 10q24 respectively by in situ hybridization

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Assignment of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization.

Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Assignment of the cyclin-dependent kinase inhibitor genes Cdkn2a and Cdkn2b to rat chromosome bands 5q32-->q34 and 5q31-->q33, respectively by fluorescence in situ hybridization, using small PCR-generated probes.

Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

The TORC1 effector kinase Npr1 fine-tunes the inherent activity of the three Mep ammonium transport proteins

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Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Assignment of the gene encoding renin binding protein (Renbp) to rat chromosome Xq37 by in situ hybridization and radiation hybrid mapping

Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe