Mémento pour la gestion des projets d'assainissement : fascicule 3 : les eaux pluviales

Ce fascicule aborde la gestion des eaux pluviales à deux niveaux : celui de la planification, du fait de l’importance de cette réflexion amont (fiche « enjeux d’urbanisme et d’aménagement »), et celui du projet d'aménagement, public ou privé, de type rénovation urbaine, création de lotissement, de ZAC, de zone industrielle, … Il ne traite pas le projet pluvial "isolé" du projet d'aménagement (création ou réhabilitation de collecteur, dispositif de traitement des eaux pluviales, …). Il insiste sur l’importance de prendre en compte la gestion des eaux pluviales très à l’amont du projet et en associant très tôt l’ensemble des acteurs de l’aménagement

Advances in the treatment of prolactinomas

Prolactinomas account for approximately 40% of all pituitary adenomas and are an important cause of hypogonadism and infertility. The ultimate goal of therapy for prolactinomas is restoration or achievement of eugonadism through the normalization of hyperprolactinemia and control of tumor mass. Medical therapy with dopamine agonists is highly effective in the majority of cases and represents the mainstay of therapy. Recent data indicating successful withdrawal of these agents in a subset of patients challenge the previously held concept that medical therapy is a lifelong requirement. Complicated situations, such as those encountered in resistance to dopamine agonists, pregnancy, and giant or malignant prolactinomas, may require multimodal therapy involving surgery, radiotherapy, or both. Progress in elucidating the mechanisms underlying the pathogenesis of prolactinomas may enable future development of novel molecular therapies for treatment-resistant cases. This review provides a critical analysis of the efficacy and safety of the various modes of therapy available for the treatment of patients with prolactinomas with an emphasis on challenging situations, a discussion of the data regarding withdrawal of medical therapy, and a foreshadowing of novel approaches to therapy that may become available in the future

Rôle des inhibiteurs de CDK dans la différenciation conjointe de l'ovocyte et des cellules du cumulus chez le bovin

Chez le bovin, l'ovocyte bloqué en prophase méiotique acquière séquentiellement son aptitude à reprendre la méiose, puis à se développer. Cette période de différenciation terminale permet le stockage d'ARN et de protéines, probablement nécessaires au développement embryonnaire précoce. Les ovocytes sortis du follicule reprennent spontanément la méiose. Une étape de pré-culture, mimant le blocage méiotique, pourrait leur permettre d'achever cette différenciation in vitro. Nous avons montré que l'utilisation de la roscovitine, inhibiteur spécifique du MPF, permet de cultiver des ovocytes en arrêt méiotique sans détériorer leur compétence au développement, ni la fonctionnalité des cellules du cumulus. Cette molécule nous a aussi permis d'améliorer notre compréhension des régulations du cycle cellulaire de l'ovocyte bovin et plus précisément de mettre en évidence l'existence d'au moins une voie de signalisation non directement liée à l'activité du MPF. Ces connaissances devraient permettre de définir des conditions de culture optimisées mais aussi la compréhension des mécanismes de reprise de la méiose des ovocytes et le discernement des événements liées à l'activité du MPF durant cette reprise.In bovine, oocytes which are blocked in meiotic prophase acquire sequentially their competence to resume and complete meiosis and the potential for development. This period of oocyte terminal differentiation allows the storage of maternal RNA and proteins necessary for embryos development. In vitro, as son as extracted from their follicular environment, oocytes spontaneously resume meiosis. A preliminary culture allowing the maintenance of oocytes at meiotic prophase might allow them to complete this differentiation step in vitro. We showed that the use of roscovitine allowed maintaining oocytes in meiotic block without loss of developmental potential, nor cumulus cells functionalities. This work will allow improving the culture conditions of bovine oocytes in order to increase their final developmental competence and will allow a better understanding the mechanisms of meiosis resumption control in oocytes and to distinguish between the events that are related to MPF activation or not in this complex process.TOURS-BU Sciences Pharmacie (372612104) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Fifth DSRG symposium at CHU UCL Namur, 18/10/2019. “Centralization of injectables and robotization”

The physico-chemical stability of an injectable preparation (IV) is conditioned by different parameters. A collaboration between the pharmacy, the chemistry laboratory and the statisticians of the scientific support unit was established in 1996, in order to carry out long-term chemical stability studies of commonly used IVs and to be able to take charge of their preparation in pharmacy. In 24 years of activity, the Drug Stability Research Group (DSRG) tested 39 IV at different concentration and temperature of storage. The DSRG has organized an annual symposium since 2015. The theme of the 2019 edition was devoted to the robotization of injectable reconstitution operations, focused on their impact on the workplace and the existing equipment

Effect of cyclin-dependent kinase inhibitors on oocyte cell cycle progression and on cumulus oocyte complex functionality

International audienc

Effect of follicular size on meiotic and developmental competence of porcine oocytes

International audienc

Several Signaling Pathways Are Involved in the Control of Cattle Oocyte Maturation

International audienc