Syndrome des antiphospholipides, thrombose vasculaire et infection virale (étude de la littérature à propos de trois observations)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

La cholestase anictérique au cours de la maladie de Horton (étude réalisée sur 88 patients adultes suivi au CHU [centre hospitalier universitaire] de Poitiers)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Intérêt et place des bandelettes urinaires aux urgences générales

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

L'association maladies systémiques et syndromes myélodysplasiques (à propos de 19 observations)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Étude des moyens possibles pour améliorer la couverture vaccinale en France (Recueil des opinions d'un échantillon de la population de la Vienne et des Deux-Sèvres)

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Safety of Immune Checkpoint Inhibitor Resumption after Interruption for Immune-Related Adverse Events, a Narrative Review

Immune checkpoint inhibitors (ICIs) have become the standard of care for several types of cancer due to their superiority in terms of survival benefits in first- and second-line treatments compared to conventional therapies, and they present a better safety profile (lower absolute number of grade 1–5 adverse events), especially if used in monotherapy. However, the pattern of ICI-related adverse events is totally different, as they are characterized by the development of specific immune-related adverse events (irAEs) that are unique in terms of the organs involved, onset patterns, and severity. The decision to resume ICI treatment after its interruption due to irAEs is challenged by the need for tumor control versus the risk of occurrence of the same or different irAEs. Studies that specifically assess this point remain scarce, heterogenous and mostly based on small samples of patients or focused only on the recurrence rate of the same irAE after ICI resumption. Moreover, patients with grade ≥3 irAEs were excluded from many of these studies. Herein, we provide a narrative review on the field of safety of ICI resumption after interruption due to irAE(s)

Serum soluble CD23 levels in giant cell arteritis'

International audienceLymphocytes and monocytes express various levels of membrane-bound CD23, the low affinity receptor for IgE (FceRII), and in some cases release it as a soluble form. Soluble CD23 (sCD23) has been implicated in the regulation of many immunological functions of T and B lymphocytes, macrophages and myeloid cells in humans. To study serum sCD23 levels in inflammatory conditions, we selected a systemic disease sensitive to corticotherapy, the giant cell arteritis, which is characterized by an inflammation of the temporal artery. Serum sCD23 levels, as measured by a radioimmunoassay, were increased in these patients, and returned to normal values within the 24 h following initiation of corticotherapy. The data suggest that the increase in sCD23 levels in giant cell arteritis results from an overproduction

Outcome of anti-PL12 positive patients with antisynthetase syndrome.[Profil évolutif du syndrome des antisynthétases avec anticorps anti-PL12]

International audienceOBJECTIVES: The aim of the present study was to assess the outcome in anti-PL12 patients with antisynthetase syndrome (ASS). METHODS: The medical records of anti-PL12 (n=5) patients with ASS were retrospectively analyzed without prior selection. To exclude false-positive patients, we included patients who were successively tested positive for anti-PL12 antibody at least twice by immunodot and/or Western blot. RESULTS: Anti-PL12 patients experienced: myositis (n=2), Raynaud's phenomenon (n=2), mechanic's hands (n=1), joint impairment (n=4), digestive involvement (n=2), and interstitial lung disease (ILD) (n=4). The two patients with myositis exhibited deterioration of muscle manifestations despite therapy. As regards outcome of ILD, patients developed resolution (n=1), stabilization (n=1) or deterioration (n=2) of pulmonary status. One patient died of pyogenic pneumonia. CONCLUSION: Our series underscores that the presence of anti-PL12 antibody is associated with a particular phenotype of ASS characterized by: (1) less frequent although severe/steroid refractory myositis; (2) less common mechanic's hands and calcinosis cutis; (3) both frequent and severe ILD. Taken together, our findings suggest that PM/DM patients should routinely undergo the search for anti-PL12 antibody as this autoantibody appears to impact patients' prognosis. Furthermore, ILD patients with anti-PL12 antibody should routinely undergo clinical screening for underlying ASS

Predictors of High Motivation Score for Performing Research Initiation Fellowship, Master 1, Research Master 2, and PhD Curricula During Medical Studies

International audienceTranslational research plays a crucial role in bridging the gap between fundamental and clinical research. The importance of integrating research training into medical education has been emphasized. Predictive factors that help to identify the most motivated medical students to perform academic research are unknown. In a cross-sectional study on a representative sample of 315 medical students, residents and attending physicians, using a comprehensive structured questionnaire we assessed motivations and obstacles to perform academic research curricula (ie, research initiation fellowship, Master 1, Research Master 2, and PhD). Independent predictive factors associated with high ''motivation score'' (top quartile on motivation score ranging from 0 to 10) to enroll in academic research curricula were derived using multivariate logistic regression analysis. Independent predictors of high motivation score for performing Master 1 curriculum were: ''considering that the integration of translational research in medical curriculum is essential'' (OR, 3.79; 95% CI, 1.49–9.59; P ¼ 0.005) and ''knowledge of at least 2 research units within the university'' (OR, 3.60; 95% CI, 2.01–6.47; P < 0.0001). Independent predictors of high motivation score for performing Research Master 2 curriculum were: ''attending physician'' (OR, 4.60; 95% CI, 1.86–11.37; P ¼ 0.001); ''considering that the integration of translational research in medical curriculum is essential'' (OR, 4.12; 95% CI, 1.51– 11.23; P ¼ 0.006); ''knowledge of at least 2 research units within the university'' (OR, 3.51; 95% CI, 1.91–6.46; P ¼ 0.0001); and ''male gender'' (OR, 1.82; 95% CI, 1.02–3.25; P ¼ 0.04). Independent predictors of high motivation score for performing PhD curriculum were: ''con-sidering that the integration of translational research in medical curriculum is essential'' (OR, 5.94; 95% CI, 2.33–15.19; P ¼ 0.0002) and ''knowl-edge of at least 2 research units within the university'' (OR, 2.63; 95% CI, 1.46–4.77; P ¼ 0.001). This is the first study that has identified factors determining motivations and barriers to carry out academic research curricula among undergraduate and postgraduate medical students. Improving these 2 areas will certainly have an impact on a better involvement of the next generation of physicians in translational medicine

Characterization of the secreted polysaccharides of the<em> Mycoplasma mycoides</em> cluster and analysis of their associated predicted genomic pathways

International audienc