Economic Activity and Institutions

This paper is one of two working papers concerning the waste management sector transition project run from MERIT under the direction of René Kemp. This paper examines some of the numerous meanings and interpretations associated with the words “institution” and “institutions” and the different levels at which the two notions are employed. Institutionalism, institutionalization, institutional change and related terms are discussed followed by an examination of the links between “institutionalism” and the discipline of economics. The analytical, policy and political implications of the institutionalist approach are discussed and ways in which the institutionalist approach may be applied to changes in the economy during transitions are explored.Institutions, Institutional Analysis, Scale, Policy

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis

Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage. Chronic myeloid leukaemia (CML) arises from a genetic alteration in a normal haemopoietic stem cell (HSC) giving rise to a leukaemic stem cell (LSC) within the bone marrow (BM) ‘niche’. CML is characterised by the presence of the oncogenic tyrosine kinase fusion protein breakpoint cluster region-abelson murine leukaemia viral oncogene homolog 1 (BCR-ABL), which is responsible for driving the disease through activation of downstream signal transduction pathways. Recent evidence from our group and others indicates that important regulatory networks involved in establishing primitive and definitive haemopoiesis during development are reactivated in myeloid leukaemia, giving rise to an LSC population with altered self-renewal and differentiation properties. In this review, we explore the role the bone morphogenic protein (BMP) signalling plays in stem cell pluripotency, developmental haemopoiesis, HSC maintenance and the implication of altered BMP signalling on LSC persistence in the BM niche. Overall, we emphasise how the BMP and Wnt pathways converge to alter the Cdx–Hox axis and the implications of this in the pathogenesis of myeloid malignancies

Technological Change and Institutions: A Case Study

The arena of mobile telecommunication in Europe has undergone a technological transition from analogue (first generation) to digital (second generation) technologies. While this transition is immediately attributable to shifts in demand and supply patterns, closer examination reveals that there are numerous other intervening factors that have facilitated this transition. This paper utilizes a conceptual framework for institutional analysis developed in earlier work to identify and discuss some of these factors. The paper concludes with a discussion of the implications from this study for an institutional perspective on technological change.economics of technology ;

“Good” Governance and Policy Analysis: What of Institutions?

Policy formation is only one the three main components in the continuum of policy formation – policy implementation – policy evaluation – policy formation. To fully understand why policy outcomes often fall significantly short of policy intentions we need to examine the structuring factors, i.e., the institutions of governance, that shape the policy process. This paper focuses on the interplay between the policy process, governance, and institutions to articulate a framework for conducting institutionally sensitive policy analysis. A comparative study of the waste subsystems in the Netherlands and the United Kingdom reveals that each subsystem is the product of its “own” institutional landscape, and not directly and immediately subject to the whims of policy making at the EU scale of governance. Although there are signs of “Europeanization” in both cases, national problems, policies, and politics as manifest through the full spectrum of formal and informal institutions continue to play a major role in facilitating and curtailing change in each of the two waste subsystems. The paper concludes with a discussion of the implications of institutionally sensitive policy analysis for the current discourse on governance for sustainable development at the European scale.Economics ;

How "black" is the black sheep compared to all others? Turkey and the EU

In this paper we question the validity of the arguments against Turkey's membership of the EU and challenge the political wisdom of excluding Turkey from Europe. First, we argue that fundamental European values are not as uniform as they are made out to be. There are significant differences among the member states and the different European regions on basic values relating to religion and democracy. Second, we argue that many of Turkey's supposed cultural differences with the rest of Europe are in fact unsubstantiated. We support our arguments by analyzing widely available macroeconomic evidence and the data from the European Values Study, 1999 (EVS99).Turkey, EU, Institutions, Institutional Analysis, Values, EVS

Transitions: An Institutionalist Perspective

A transition to a new technological regime is complete (and stable) when accompanied with a co-stabilization between the mode of regulation and the regime of accumulation. Key to understanding the dynamics of transitions are the factors, including institutions, that “regulate” and stabilize the regime of accumulation over time. However, the available frameworks for institutional analysis employ arbitrary and narrow definition of institutions, focus mainly on the policy domain, and do not pay sufficient attention to the evolutionary characteristics of change as manifested in emergence of numerous institutions that underlie transitions. This paper consists of three parts. The first part critically reviews and synthesizes some of the main approaches for conducting institutional analysis. The second part rearticulates the concept of “transitions”, or technological regime shifts, from a systems perspective to make a case for investigating transitions as multi-level, multi-scale, and multi-system phenomena best understood in their institutional contexts. The third part proposes a framework for examining institutional change and demonstrates how this framework may be used to identify the key factors and conditions whose convergence might result in transitions in a given subsystem. Examples are drawn from the Dutch waste management subsystem to demonstrate how this framework should be operationalized.economics of technology ;

Economic growth, innovation systems, and institutional change: A Trilogy in Five Parts

Development and growth are products of the interplay and interaction among heterogeneous actors operating in specific institutional settings. There is a much alluded-to, but under-investigated, link between economic growth, innovation systems, and institutions. There is widespread agreement among most economists on the positive reinforcing link between innovation and growth. However, the importance of institutions as catalysts in this link has not been adequately examined. The concept of innovation systems has the potential to fill this gap. But these studies have not conducted in-depth institutional analyses or focussed on institutional transformation processes, thereby failing to link growth theory to the substantive institutional tradition in economics. In this paper we draw attention to the main shortcomings of orthodox and heterodox growth theories, some of which have been addressed by the more descriptive literature on innovation systems. Critical overviews of the literatures on growth and innovation systems are used as a foundation to propose a new perspective on the role of institutions and a framework for conducting institutional analysis using a multi-dimensional typology of institutions. The framework is then applied to cases of Taiwan and South Korea to highlight the instrumental role played by institutions in facilitating and curtailing economic development and growth.economics of technology ;

Regional Innovation Systems: Current Discourse and Challenges for Future Research

In recent years, the concept of Regional Innovation Systems has evolved into a widely used analytical framework generating the empirical foundation for innovation policy making. Yet, the approaches utilizing this framework remain ambiguous on such key issues as the territorial dimension of innovation, e.g., the region, and the apparently important role played by “institutions” or the institutional context in the emergence and sustenance of regional innovation systems. This paper reviews and summarizes the most important ideas and arguments of the recent theorizing on regional innovation systems to provide the basis for a critical examination of such issues as (1) definition confusion and empirical validation; (2) the territorial dimension of regional innovation systems; and (3) the role of institutions. Key-words: Regional innovation systems, institutions, regions, research, policy JEL CODES: O31, R58

Economic growth, innovation systems, and institutional change: a trilogy in five parts

Development and growth are products of the interplay and interaction among heterogeneous actors operating in specific institutional settings. There is a much alluded-to, but under-investigated, link between economic growth, innovation systems, and institutions. There is widespread agreement among most economists on the positive reinforcing link between innovation and growth. However, the importance of institutions as catalysts in this link has not been adequately examined. The concept of innovation systems has the potential to fill this gap. But these studies have not conducted in-depth institutional analyses or focussed on institutional transformation processes, thereby failing to link growth theory to the substantive institutional tradition in economics. In this paper we draw attention to the main shortcomings of orthodox and heterodox growth theories, some of which have been addressed by the more descriptive literature on innovation systems. Critical overviews of the literatures on growth and innovation systems are used as a foundation to propose a new perspective on the role of institutions and a framework for conducting institutional analysis using a multi-dimensional typology of institutions. The framework is then applied to cases of Taiwan and South Korea to highlight the instrumental role played by institutions in facilitating and curtailing economic development and growth

Realizing spin-Hamiltonians in nanoscale active photonic lattices

Spin models arise in the microscopic description of magnetic materials and have been recently used to map certain classes of optimization problems involving large degrees of freedom. In this regard, various optical implementations of such Hamiltonians have been demonstrated to quickly converge to the global minimum in the energy landscape. Yet, so far, an integrated nanophotonic platform capable of emulating complex magnetic materials is still missing. Here, we show that the cooperative interplay among vectorial electromagnetic modes in coupled metallic nanolasers can be utilized to implement certain types of spin Hamiltonians. Depending on the topology/geometry of the arrays, these structures can be governed by a classical XY Hamiltonian that exhibits ferromagnetic and antiferromagnetic couplings, as well as geometrical frustration. Our results pave the way towards a scalable nanophotonic platform to study spin exchange interactions and could address a variety of optimization problems