4 research outputs found
The Prevalence Of Antiphospholipid Syndrome In Patients With Recurrent Pregnancy Loss: A Report From South Of Iran
In order to determine the role of different anti-phospholipid
antibodies as an etiologic factor in recurrent pregnancy failure, a
prospective study was done on one-hun-dred and thirty-eight women who
had unexplained recurrent pregnancy loss (group I) with one-hundred
well-matched women with normal reproductive outcome allocated as
control group (GII). Sera from 138 patients and 100 controls were
analyzed for anticardiolipin antibody (ACLA) and lupus anticoagulant
(LA). ACLA was measured by Elisa and LA by activated PTT. Sixteen
women (11.6%) had positive ACLA in group I, while 3 (3%) of group II
were positive for this antibody (p= 0.0157 and odds ratio = 4.24). LA
was positive in 12(8.7%) of group I and 3(3%) of group II, but the
difference was not significant (p= 0.074, odds ratio=3.08). Overall 24
women (17.4%) were positive for one of the mentioned antibodies (p=
0.00055, OR= 6.81). Four patients were positive for both antibodies.
This study emphasizes the relationship between antiphospholipid
syndrome and recurrent pregnancy failure