Updating the Bogardus social distance studies: A new national survey

The last quarter of the 20th century witnessed a number of events and social transformations that have had great implications for religious and ethnic relations around the world. This study seeks to gauge the changes in sentiment towards various U.S. ethnic and religious groups by updating and replicating the Bogardus social distance scale. The Bogardus study, which was designed to measure the level of acceptance that Americans feel towards members of the most common ethnic groups in the United States, was conducted five times between 1920 and 1977 with very few changes in research design. Consistent with prior replications, the authors of this study collected a random sample of 2,916 college students and administered the social distance scale in the form of a questionnaire. The findings indicate that the mean level of social distance towards all ethnic groups, as well as the spread between the groups with the highest and lowest levels of social distance, decreased since 1977. Mean comparisons and ANOVA test also showed that gender, nation of origin, and race are all significant indicators of the level of social distance towards all groups

An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data

Citation: Shi, Z. Z., Chapes, S. K., Ben-Arieh, D., & Wu, C. H. (2016). An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data. Plos One, 11(8), 39. doi:10.1371/journal.pone.0161131We present an agent-based model (ABM) to simulate a hepatic inflammatory response (HIR) in a mouse infected by Salmonella that sometimes progressed to problematic proportions, known as "sepsis". Based on over 200 published studies, this ABM describes interactions among 21 cells or cytokines and incorporates 226 experimental data sets and/or data estimates from those reports to simulate a mouse HIR in silico. Our simulated results reproduced dynamic patterns of HIR reported in the literature. As shown in vivo, our model also demonstrated that sepsis was highly related to the initial Salmonella dose and the presence of components of the adaptive immune system. We determined that high mobility group box-1, C-reactive protein, and the interleukin-10: tumor necrosis factor-a ratio, and CD4+ T cell: CD8+ T cell ratio, all recognized as biomarkers during HIR, significantly correlated with outcomes of HIR. During therapy-directed silico simulations, our results demonstrated that anti-agent intervention impacted the survival rates of septic individuals in a time-dependent manner. By specifying the infected species, source of infection, and site of infection, this ABM enabled us to reproduce the kinetics of several essential indicators during a HIR, observe distinct dynamic patterns that are manifested during HIR, and allowed us to test proposed therapy-directed treatments. Although limitation still exists, this ABM is a step forward because it links underlying biological processes to computational simulation and was validated through a series of comparisons between the simulated results and experimental studies

Contemporary social problems, 5th ed./ Parrillo

xxii, 500 hal.: ill.; 23 cm

Encyclopedia of social problems 1 and 2/ Edit.: Vincent N. Parrillo

xliv, 1045 hal.; 25 cm

Encyclopedia of social problems 1 and 2/ Edit.: Vincent N. Parrillo

xliv, 1045 hal.; 25 cm