Violation of the Δ\DeltaI=1/2 rule in the nonmesonic weak decay of Λ\Lambda hypernuclei

Violations of the $\Delta$I=1/2 rule are investigated in the nonmesonic weak hypernuclear decay using a weak $\Lambda$N$\to$NN transition potential based on meson exchange. While the weak $\Delta$I=3/2 matrix elements of baryons with pseudoscalar mesons are known to be very small, the same matrix elements of baryons with vector mesons, evaluated in the factorization approximation, are found to be significant. Within the uncertainties of the factorization approximation we find that the total rate increases by at most 6% lying within the error bars of the more recent experimental result. The neutron- to proton-induced rate, on the other hand, can change by up to a factor of two, while the asymmetry parameter is strongly affected as well.Comment: 17 pages. Paper related to a contribution presented at the International Conference on Hypernuclear and Strange Particle Physics (HYP97). Submitted to Phys. Lett.

Механізми вдосконалення управління інноваційною діяльністю в умовах економічної нестабільності

Розглядаються особливості глобально-постіндустріального розвитку. Досліджено методичні основи системи моніторингу, прогнозування, планування і забезпечення реалізації інноваційної діяльності та головні засади механізму її функціонування.Peculiarities of the global post-industrial development are reviewed. Methodical fundamentals of the system for monitoring, forecasting, planning and provision of innovation activity implementation and main principles of its functioning mechanisms are reviewed

The weak strangeness production reaction pn→pΛpn \to p\Lambda in a one-boson-exchange model

The weak production of Lambdas in nucleon-nucleon scattering is studied in a meson-exchange framework. The weak transition operator for the $NN \to N \Lambda$ reaction is identical to a previously developed weak strangeness-changing transition potential $\Lambda N \to NN$ that describes the nonmesonic decay of hypernuclei. The initial $NN$ and final $YN$ state interaction has been included by using realistic baryon-baryon forces that describe the available elastic scattering data. The total and differential cross sections as well as the parity-violating asymmetry are studied for the reaction $pn \to p\Lambda$. These observables are found to be sensitive to the choice of the strong interaction potential and the structure of the weak transition potential.Comment: 25 pages, 8 postscript figures. Submitted to Phys. Rev.

Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

Stem cell factor (SCF) has an important role in the proliferation, differentiation, survival, and migration of hematopoietic cells. SCF exerts its effects by binding to cKit, a receptor with intrinsic tyrosine kinase activity. Activation of phosphatidylinositol 3'-kinase (PI3-K) by cKit was previously shown to contribute to many SCF-induced cellular responses. Therefore, PI3-K-dependent signaling pathways activated by SCF were investigated. The PI3-K-dependent activation and phosphorylation of the tyrosine kinase Tec and the adapter molecule p62Dok-1 are reported. The study shows that Tec and Dok-1 form a stable complex with Lyn and 2 unidentified phosphoproteins of 56 and 140 kd. Both the Tec homology and the SH2 domain of Tec were identified as being required for the interaction with Dok-1, whereas 2 domains in Dok-1 appeared to mediate the association with Tec. In addition, Tec and Lyn were shown to phosphorylate Dok-1, whereas phosphorylated Dok-1 was demonstrated to bind to the SH2 domains of several signaling molecules activated by SCF, including Abl, CrkL, SHIP, and PLCgamma-1, but not those of Vav and Shc. These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling

Drought and coyotes mediate the relationship between mesopredators and human disturbance in California

Mesopredators in California are facing two major changes to their ecosystem: drought and the expansion of human disturbance. As a result, mesopredators are likely shifting their habitat use as well as their interspecies interactions to balance resource needs and risk-taking on the landscape. In response to severe drought, the California Department of Fish and Wildlife deployed 585 camera traps throughout the Mojave Desert and Central Valley documenting mammalian mesopredator presence in a drought year (2016) and a post-drought year (2017). The objectives of this study were to examine spatial patterns of mesopredator occurrence and co-occurrence with a dominant predator, the coyote (Canis latrans), at a large spatial scale across varying levels of human disturbance and to investigate how drought may mediate these relationships. Single-season, single-species occupancy models were used to elucidate the relationship between human disturbance, drought, and mesopredator habitat use in both ecoregions. Conditional two-species occupancy models were then fit to establish the effect coyotes may have had on subordinate mesopredators and their relationships with human disturbance during and after the drought. I found that human disturbance differentially affected both the occupancy and detection of mesopredator species and that these relationships were sometimes mediated by drought and the presence of coyotes. Except for the domestic cat (Felis catus), all mesopredators showed some kind of response to drought. Detection of mesopredators in the Central Valley was typically higher in 2016, especially in low disturbance sites, indicating that species became more active during the drought to meet resource needs. However, detection and occupancy of mesopredators in the Mojave Desert tended to increase after the drought, suggesting that species were responding to an increase in resources, possibly the density of prey. Coyotes in the Mojave Desert became more detectable in high human disturbance in 2016 and less detectable in 2017, signifying that they were increasing activity in human disturbance during the drought, possibly to obtain anthropogenic resources. Additionally, subordinate species, particularly in the Central Valley, appeared to take greater risks during the drought with increased use of water sources, despite the presence of coyotes. These findings suggest that drought not only affects individual species and their relationships to human disturbance, but that it can also impact their interspecies interactions and use of different landscape features

Tyrosine kinase receptor RON functions downstream of the erythropoietin

Erythropoietin (EPO) is required for cell survival during differentiation and for progenitor expansion during stress erythropoiesis. Although signaling pathways may couple directly to docking sites on the EPO receptor (EpoR), additional docking molecules expand the signaling platform of the receptor. We studied the roles of the docking molecules Grb2-associated binder-1 (Gab1) and Gab2 in EPO-induced signal transduction and erythropoiesis. Inhibitors of phosphatidylinositide 3-kinase and Src kinases suppressed EPO-dependent phosphorylation of Gab2. In contrast, Gab1 activation depends on recruitment and phosphorylation by the tyrosine kinase receptor RON, with which it is constitutively associated. RON activation induces the phosphorylation of Gab1, mitogen-activated protein kinase (MAPK), and protein kinase B (PKB) but not of signal transducer and activator of transcription 5 (Stat5). RON activation was sufficient to replace EPO in progenitor expansion but not in differentiation. In conclusion, we elucidated a novel mechanism specifically involved in the expansion of erythroblasts involving RON as a downstream target of the Epo

Ювілеї та пам’ятні дати

Native mass spectrometry is emerging as a powerful tool for the characterization of intact antibodies and antibody-based therapeutics. Here, we demonstrate new possibilities provided by the implementation of a high mass quadrupole mass selector on the recently introduced Orbitrap Exactive EMR mass spectrometer. This configuration allows precursor ion selection, and thus tandem mass spectrometry experiments, even on analytes with masses in the hundreds of kilodaltons. We apply tandem mass spectrometry to localize the drug molecules in the therapeutic antibody-drug conjugate brentuximab vedotin, which displays a heterogeneous drug load. Our tandem MS data reveal that drug conjugation takes place nonhomogeneously to cysteine residues both on the light and heavy chains. Next, we analyzed how many antigens bind to IgG hexamers, based on a recently described antibody mutant IgG1-RGY that forms hexamers and activates complement in solution. The fully saturated IgG1-RGY-antigen complexes displayed a stoichiometry of IgG:CD38 of 6:12, possessing a molecular weight of about 1.26 MDa and demonstrating that IgG assembly does not hamper antigen binding. Through tandem MS experiments, we retrieve information about the spatial arrangement and stoichiometry of the subunits within this complex. These examples underscore the potential of this further modified Orbitrap-EMR instrument especially for the in-depth characterization by native tandem mass spectrometry of antibodies and antibody-based constructs

Финансовое обеспечение деятельности туристического предприятия

Целью статьи является разработка рекомендаций по повышению эффективности финансового обеспечения деятельности туристического предприятия, определение приоритетных путей совершенствования финансовых показателей его деятельности