58 research outputs found
Genome-wide analyses identify common variants associated with macular telangiectasia type 2
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS) with 476 cases and 1,733 controls of European ancestry. Genome-wide significant associations (P < 5 × 10−8) were identified at three independent loci (rs73171800 at 5q14.3, P = 7.74 × 10−17; rs715 at 2q34, P = 9.97 × 10−14; rs477992 at 1p12, P = 2.60 × 10−12) and then replicated (P < 0.01) in an independent cohort of 172 cases and 1,134 controls. The 5q14.3 locus is known to associate with variation in retinal vascular diameter, and the 2q34 and 1p12 loci have been implicated in the glycine/serine metabolic pathway. We subsequently found significant differences in blood serum levels of glycine (P = 4.04 × 10−6) and serine (P = 2.48 × 10−4) between MacTel cases and controls
The Distribution and Research Value of Archaeological Mussel Shell: An Overview from Mississippi
Changes to freshwater mussel assemblages after 25 years of impoundment and river habitat fragmentation
Understanding the Damages Caused by the 1999 Kocaeli Earthquake on One of the Towers of the Theodosian Walls of Constantinople
A Comparison of Freshwater Mussels (Unionidae) from a Late-Archaic Archeological Excavation with Recently Sampled Verdigris River, Kansas, Populations
Paleoclimate of the Little Ice Age to the Present in the Kankakee Valley of Illinois and Indiana, USA Based on 18
Using Instrument-Guided Team Reflection and Debriefing to Cultivate Teamwork Knowledge, Skills, and Attitudes in Pre-Clerkship Learning Teams
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