Some side effects of heparin, heparinoids, and their antagonists

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117045/1/cpt196673379.pd

Some aspects of the pharmacology of oral anticoagulants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116956/1/cpt1970113312.pd

Deep venous thrombosis and pulmonary embolism : Prediction, prevention and treatment*

The manifestations of thromboembolism are highly variable and frequently obscure. Clinical diagnosis of these entities is difficult, and the majority of cases will not be diagnosed by the means presently available to us. Nevertheless, a heightened awareness of the vagaries of this disease can result in considerable improvement in diagnostic accuracy. Prompt diagnosis on the basis of the slightest clinical suspicion, followed by immediate and adequate anticoagulant therapy, should result in a measureable decrease in thromboembolic complications. However, if one hopes to achieve a profound reduction in incidence of thromboembolism, the only approach presently available is prophylactic rather than therapeutic. The use of measures to increase venous return in patients who are immobilized in bed, plus the institution of prophylactic anticoagulant therapy in a selected group of patients with a high predisposition to the development of thromboembolic diseases, should result in a significant reduction in disability and mortality from this theoretically preventable disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32447/1/0000529.pd

Acquired right ventricular outflow tract obstruction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33562/1/0000063.pd

Correlation of plasma levels of digoxin in cardiac patients with dose and measures of renal function

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/117126/1/cpt1974153291.pd

Importance of clinical assessment in selecting patients for pulmonary arteriography

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23623/1/0000586.pd

Recurrence of a left atrial myxoma

A fatal recurrence of a left atrial myxoma was observed despite resection of the original tumor complete with its stalk and a portion of atrial septum. The evidence suggests that this recurrent tumor developed from "pre-tumor" cells in the region of the fossa ovalis. The rate of growth of the second tumor was faster than would have been predicted. Clinical manifestations were similar to those with the initial tumor. Wide excision of the atrial septum with the stalk of such tumors should offer the best chance for operative cure, but prolonged postoperative observation is important if signs of recurrence are to be detected at a time when operative removal can be carried out with minimal risk to the patient.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34209/1/0000498.pd

Certain immunologic substances in the serum of patients with myocardial infarction and other cardiovascular diseases

Serum anti-heart hemagglutinins occurred in 29 per cent of patients with myocardial infarction, as compared to 6 per cent of normal control subjects, had a high prevalence in patients with rheumatic heart disease, occurred in 2 of 5 with a cardiomyopathy, and had a very low frequency in individuals who had noncardiac diseases with or without a vascular component.Serum inhibitors of anti-heart hemagglutinations were found in one half of the patients with myocardial infarction and in those having diseases with vascular involvement, e.g., lupus erythematosus, pulmonary embolism, and syphilitic aortitis. The inhibitors found associated with cardiovascular diseases inhibit at either the antigen or antiserum site during the hemagglutination test, whereas the normal sera which display inhibition do so at both sites, suggesting a lack of anti-heart specificity. From these data it appears that, with the sequential use of both the anti-heart hemagglutination technique and the inhibition test, positive results can be obtained in over one half of the patients with myocardial infarction.As diagnostic adjuncts, these tests still offer only limited assistance in the clinical detection of cardiovascular diseases. A positive anti-heart hemagglutination inhibition test alone appears to be related to less specific vascular damage.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33389/1/0000788.pd

A natural history study of the prognostic role of coronary arteriography

Coronary cinearteriograms, clinical records, and left ventriculograms of 304 patients studied for evaluation of chest pain were reviewed. Clinical and follow-up data on survival of the normal subjects and the nonoperative group with abnormal arteriograms are presented.Ninety-two per cent of patients with typical angina pectoris had serious coronary occlusive disease. Ninety-eight per cent of patients with relatively normal coronary arteriograms survived for one to 60 or more months (mean follow-up period 24 months).There was a high mortality rate when the left main coronary artery was involved (47 per cent) and when the left coronary anterior descending branch was seriously occluded (28 per cent when arteriographic scores were high and 14 per cent when total scores were low) and a low mortality rate (0 to 7 per cent) when the LAD was normal. Mean follow-up interval in these groups was 19 months.The mortality rate was nearly three times greater when patients had QRS changes on ECG of prior myocardial infarction and six times greater when left ventricular contraction was significantly impaired.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22297/1/0000740.pd

Exact Scale Invariance in Mixing of Binary Candidates in Voting Model

We introduce a voting model and discuss the scale invariance in the mixing of candidates. The Candidates are classified into two categories $\mu\in \{0,1\}$ and are called as `binary' candidates. There are in total $N=N_{0}+N_{1}$ candidates, and voters vote for them one by one. The probability that a candidate gets a vote is proportional to the number of votes. The initial number of votes (`seed') of a candidate $\mu$ is set to be $s_{\mu}$. After infinite counts of voting, the probability function of the share of votes of the candidate $\mu$ obeys gamma distributions with the shape exponent $s_{\mu}$ in the thermodynamic limit $Z_{0}=N_{1}s_{1}+N_{0}s_{0}\to \infty$. Between the cumulative functions $\{x_{\mu}\}$ of binary candidates, the power-law relation $1-x_{1} \sim (1-x_{0})^{\alpha}$ with the critical exponent $\alpha=s_{1}/s_{0}$ holds in the region $1-x_{0},1-x_{1}<<1$. In the double scaling limit $(s_{1},s_{0})\to (0,0)$ and $Z_{0} \to \infty$ with $s_{1}/s_{0}=\alpha$ fixed, the relation $1-x_{1}=(1-x_{0})^{\alpha}$ holds exactly over the entire range $0\le x_{0},x_{1} \le 1$. We study the data on horse races obtained from the Japan Racing Association for the period 1986 to 2006 and confirm scale invariance.Comment: 19 pages, 8 figures, 2 table