A rare case of serologically diagnosed overlap syndrome presents as an idiopathic inflammatory myositis without any overlapping features

Overlap syndrome is a rare inflammatory rheumatic condition that shares features suggestive of at least two distinct autoimmune diseases with a reported prevalence of less than 34/100,000 persons and an incidence of less than 20/million/year. One example of an overlap syndrome is the presence of dermatomyositis or polymyositis with other autoimmune afflictions such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or Sjogren’s syndrome. We present a case report of a 22-year-old male presented with progressive weakness in both upper and lower limbs without any other significant complaints. On investigation, serology revealed antibodies suggestive of overlap syndrome, which on further investigations, categorized as idiopathic inflammatory myositis (IIM). This shows that overlap syndrome, as an IIM, is one of the differential diagnoses in patients presenting with progressive extremity weakness involving both extremities even if there is no involvement of any sensory function

FORMULATION OPTIMIZATION AND CHARACTERIZATION OF GANCICLOVIR LOADED DRY CHITOSAN NANOPARTICLES

ABSTRACTObjective: The objective of this work was to formulate, optimize, and characterize ganciclovir (GCV) loaded dry chitosan nanoparticles (CSNPs).Methods: The GCV loaded CSNPs was prepared by ionic gelation method. Box–Behnken design was employed to optimize the influence of independentprocess and formulation variables like drug to polymer ratio, concentration of sodium tripolyphosphate, and stirring time (min) on the dependentvariables such as particle size (PS) and drug encapsulation efficiency (% EE). The optimum conditions were determined by regression analysis of theoutput data.Results: The independent variables had interactive effects and they affected both the responses. The optimum formulation had PS within the range of100-120 nm and % EE between 85% and 86%. The prepared GCV loaded CSNPs were dried by fluidized bed drying method. Fourier transform infraredspectra showed there was no physicochemical interaction between GCV and CS. Powder X-ray diffraction study showed less intense crystalline peaksindicated that GCV may exist in the formulation as amorphous nanodispersion or molecular dispersion form. Differential scanning calorimetry studywas performed which indicated that the drug was molecularly dispersed inside the matrix of CS. Higuchi model was the best to fit the in vitro releasedata for the GCV loaded CSNPs.Conclusion: From the results, it can be concluded that the GCV loaded dry CSNPs were formulated, optimized, and characterized using desiredpharmacotechnical properties.Keywords: Chitosan nanoparticles, Box–Behnken design, Sodium tripolyphosphate, Ionic gelation

Power Reduction Sleep Scheduling Technique for Cloud Integrated Green Social Sensor Network

The wireless sensor network is the maximum appropriate technology nowadays with such awesome applications and areas including Infrastructure tracking, environment tracking, health care tracking, etc. Cloud Computing has fantastic data collecting skills and effective data processing ability. Social Network is a group of People or organizations of human beings with similar intentions. Social Sensor Cloud is one type of expertise-sharing mechanism wherein similar types of human beings can connect. Energy Consumption is nowadays the largest challenge as far as the concern with green environment. Because the battery life of the sensor is so limited, the Social Sensor Cloud must be energy efficient. As a result, this article will concentrate on Energy-Efficient Techniques for the Social Sensor Cloud. According to our findings, findings, the majority of energy-saving measures will cope with not unusual place Parameters including Network Lifetime, Network Work rate, Throughput, Energy, Bandwidth, etc. We will Summarize current Technology and we Will Provide Our Architecture for Energy Reduction in Social Sensor Cloud

FORMULATION DEVELOPMENT AND EVALUATION OF TEMOZOLOMIDE LOADED HYDROGENATED SOYA PHOSPHATIDYLCHOLINE LIPOSOMES FOR THE TREATMENT OF BRAIN CANCER

Objective: The objective of this study was to encapsulate temozolomide (TMZ) in the liposomal formulation for the treatment of glioblastoma. TMZis one of the most effective substances in vitro against cells derived from glioblastoma. However, it may not have a significant effect in vivo due topoor penetration in brain which may be attributed to the blood-brain-barrier. The main objective of this investigation is to develop a liposomal drugdelivery system which could improve the brain targeting, and solve the treatment-related problems.Methods: In this study, TMZ loaded liposomes were prepared by ethanol injection method. The characterization of formulated liposomes was carriedout by vesicle size, entrapment efficiency, surface morphology, and in vitro drug release study. The prepared liposomes were also evaluated for celluptake and cell cytotoxicity studies.Results: Particle size and entrapment efficiency were found to be 105.7±3.9 nm and 78.25±0.98%, respectively. 75% of the entrapped drug wasreleased in 24 hrs from the selected liposomal formulation. Cell uptake study reveals that hydrogenated soya phosphatidylcholine (HSPC) loaded TMZliposomes interact with the glioblastoma cells and kill the cancer cells effectively. Cytotoxicity assay confirms that drug loaded HSPC liposomes aremore efficient with respect to killing of glioblastoma cells as compared to plain drug.Conclusion: These results suggest that the TMZ loaded HSPC liposome may serve as a proficient targeted drug delivery system for the effectivemanagement of glioblastoma.Keywords: Temozolomide, Liposomes, Hydrogenated soya phosphatidylcholine, Cholesterol, Glioblastoma

A systematic literature review on Security of Unmanned Aerial Vehicle Systems

Unmanned aerial vehicles (UAVs) are becoming more common, and their operational range is expanding tremendously, making the security aspect of the inquiry essential. This study does a thorough assessment of the literature to determine the most common cyberattacks and the effects they have on UAV assaults on civilian targets. The STRIDE assault paradigm, the challenge they present, and the proper tools for the attack are used to categorize the cyber dangers discussed in this paper. Spoofing and denial of service assaults are the most prevalent types of UAV cyberattacks and have the best results. No attack style demands the employment of a hard-to-reach gadget, indicating that the security environment currently necessitates improvements to UAV use in civilian applications.Comment: 10 Pages, 4 Figure

Improving the Isotretinoin Photostability by Incorporating in Microemulsion Matrix

The present paper demonstrates the increased photostability of isotretinoin when loaded in microemulsion. The photodegradation of isotretinoin, in methanol and microemulsion formulation was studied under direct sun light. The photodegradation process was monitored by UV spectrophotometry. In methanol solution, isotretinoin undergoes complete photodegradation just within a few minutes of light exposure. Isotretinoin incorporated in microemulsion formulation showed an increased stability in comparison to the methanol solutions. In particular for isotretinoin, a residual concentration of 75% was still present after a light irradiance versus a residual value of just 16% measured at the same time in methanol solution. Further, degradation kinetic parameters of isotretinoin-loaded microemulsion formulation were demonstrated increase isotretinoin half-life about five-times in comparison with a methanol solution under a direct sun light