Radiating black hole solutions in arbitrary dimensions

We prove a theorem that characterizes a large family of non-static solutions to Einstein equations in $N$-dimensional space-time, representing, in general, spherically symmetric Type II fluid. It is shown that the best known Vaidya-based (radiating) black hole solutions to Einstein equations, in both four dimensions (4D) and higher dimensions (HD), are particular cases from this family. The spherically symmetric static black hole solutions for Type I fluid can also be retrieved. A brief discussion on the energy conditions, singularities and horizons is provided.Comment: RevTeX 9 pages, no figure

Dolichol: A Component of the Cellular Antioxidant Machinery

Dolichol, an end product of the mevalonate pathway, has been proposed a biomarker of aging, but its biological role, not to mention its catabolism, has not been fully understood. UV-B radiation was used to induce oxidative stress in isolated rat hepatocytes by the collagenase method. Effects on dolichol, phospholipids-bound polyunsaturated fatty acids (PL PUFA) and known lipid soluble antioxidants [coenzyme Q (CoQ) and α-tocopherol] were studied. The increase in oxidative stress was detected by a probe sensitive to reactive oxygen species (ROS). Peroxidation of lipids was assessed by measuring the release of thiobarbituric acid reactive substances (TBARS). Dolichol, CoQ and α-tocopherol were assessed by high-pressure liquid chromatography (HPLC), PL PUFA by gas-liquid chromatography (GC). UV-B radiation caused an immediate increase in ROS as well as lipid peroxidation and a simultaneous decrease in the levels of dolichol and lipid soluble antioxidants. Decrease in dolichol paralleled changes in CoQ levels and was smaller than that in α-tocopherol. The addition of mevinolin, a competitive inhibitor of the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoAR), magnified the loss of dolichol and was associated with an increase in TBARS production. Changes in PL PUFA were minor. These findings highlight that oxidative stress has very early and similar effects on dolichol and lipid soluble antioxidants. Lower levels of dolichol are associated with enhanced peroxidation of lipids, which suggest that dolichol may have a protective role in the antioxidant machinery of cell membranes and perhaps be a key to understanding some adverse effects of statin therapy

Changes in dolichol and pentosidine levels in the age-mismatched heterotopically transplanted rat heart.

none9To address some basic questions about primary and secondary events in the process of aging in different cell and tissue types, we studied changes in the levels of biomarkers of the aging cells (dolichol) and connective tissue (pentosidine) in the heart of older (22-month-old) Lewis rats heterotopically transplanted in younger (3-month-old) syngenic recipients. Results showed that age-mismatched transplantation did not alter the age-related accumulation of dolichol and significantly reduced the accumulation of pentosidine in cardiac tissue. It is concluded that aging of heart muscle and connective tissues is controlled by two independent clocks; that accumulation of dolichol in older tissues may be a primary consequence of the process of aging, whereas the accumulation of pentosidine may be secondary, perhaps to changes in circulating cells endowed with advanced glycation end products-specific receptors; in the perspective of organ transplantation, the environment of a younger host may positively interact with the graft and rejuvenate its collagenCAVALLINI G.; DI STEFANO R.; BONANOMI G.; MOSCA F.; P. ODETTI; PARENTINI I.; POGGI A.; ROSSI S.; BERGAMINI E.Cavallini, G.; DI STEFANO, R.; Bonanomi, G.; Mosca, F.; Odetti, Patrizio; Parentini, I.; Poggi, A.; Rossi, S.; Bergamini, E

Insulin release form isolated, human islets after acute or prolonged exposure to glimepiride

[abstract non disponibile

Stress ossidativo, alterazioni dell’HMGCoA reduttasi e del metabolismo degli isoprenoidi, e patogenesi dell’ipercolesterolemia dell’anziano

The aging process enhances oxidative stress and causes an alteration in membrane lipid and an increase in dolichol tissue levels and rate of synthesis and an increase in cholesterol synthesis and plasma levels. Recent observations show that changes in dolichol and cholesterol synthesis are secondary to a constitutive activation of HMGCoA activity, which may be caused by the ageing-dependent increase in oxidative stress in membranes