1 research outputs found
The effect of clofibrate on decreasing serum Bilirubin in healthy term neonates under home phototherapy
Objective: this study was designed to determine the effect of
clofibrate on neonatal uncomplicated jaundice treated with home
phototherapy. Methods: This clinical trial study was performed on 60
newborns with jaundice that received home phototherapy. Inclusion
criteria were body weight between 2500 to 4000 gr, breastfed, total
serum bilirubin (TSB) between 14 to 20 mg/dl, aged over 72 hours. The
neonates were randomly divided into two groups. All received home
phototherapy. Group I received a single dose of 50 mg/kg clofibrate and
the other group served as control group. Total serum bilirubin level
was measured every 24 hours. Findings: Two groups were matched
regarding weight, sex, age and first TSB. At 24 and 48 hours of
treatment, the mean values of TSB in the clofibrate group were 13.72
(1.56), 9.5 (0.56) and in the control group 15.30 (1.44), 12.6 (1.44).
The results show that TSB was significantly decreased after 24 and 48
hours in clofibrate group (P<0.001). The mean duration of
phototherapy in group I was 72(0.0) hours and in the control group
76.80 (±9.76) hours. The duration of phototherapy was
significantly shorter in clofibrate group (P<0.001). Conclusion:
clofibrate is effective for outpatients with neonatal
hyperbilirubinemia who are under home phototherapy. Of course, further
studies are needed for approved routine use of this drug in the
treatment of neonatal jaundice