GEOGEBRA APPLIANCE IN THE TEACHING OF MATHEMATICS IN LOWER GRADES OF ELEMENTARY SCHOOL

Technology has been imposed on today’s students since their birth, them being surrounded by computers, tablets and other tools of the digital age. Mathematics is a teaching subject which represents the gratest obstacle to students in their schooling and prejudice against it has existed since the very beginning of schooling. Information and communication technology can make its learning much easier, both to students and teachers. The aim of the paper was to determine if there was a difference in the achievement of the students taught by contemporary GeoGebra classes and traditional classes. By conducting the research and interpreting the results, the GeoGebra program was found to have a significant role in learning of new contents in mathematics, and students have shown progress by working in the contemporary mode of GeoGebra program. It can be said that this program is very convenient in learning maths, especially in geometry, and the students were satisfied with their work in the program, what is confirmed with the results of the survey questionnaires on satisfaction issue

Variations in amino acid composition in bacterial single stranded DNA–binding proteins correlate with GC content

Background and purposeSSB proteins are essential for the maintenance of the genome in all domains of life. Most bacterial SSBs are active as homotetramers. Each monomer comprises N-terminal domain (OB-fold) which is responsible for ssDNA binding and a disordered C-terminal domain (Ct) with a conserved acidic tail responsible for protein interactions.The variations in these essential proteins prompted us to conduct in silico analyses of the aa composition and properties of two distinct SSB domains in relation to bacterial GC content.Materials and methodsSSB sequences were collected from genomes covering a wide range of GC content from 14 bacterial phyla. The maximum-likelihood (ML) trees were constructed for SSB sequences and corresponding 16S rRNA genes. The aa contents of OB folds and Ct domains were subsequently analysed. ResultsWe showed that SSB proteins followed predicted amino acid (aa) composition as a function of genomic GC content. However, two distinct domains of SSB exhibit significant differences to the expected aa composition. Variations in aa proportion were more prominent in Ct domains. Elevated accumulation of Gly (up to 60 %) and Pro (up to 24 %), significant drop in the proportion of basic Lys and reduction in hydrophobic Leu, Ile and Val were identified in Ct domains of SSBs from high GC genomes. Consequently, this influences the biochemical properties of Ct domains.ConclusionsBased on this comparative study of SSBs we conclude that genomic GC content and two distinct domains with different functional roles participate in shaping aa composition of SSB proteins.</p