La crisis sociopolítica colombiana: un análisis no coyuntural de la coyuntura

Gran parte de los análisis de coyuntura que se realizan sobre la situación colombiana tienen la limitan-te de ser comentarios sobre uno u otro hecho destacado que sucedió en la última semana o, con suerte para el análisis, en el último mes. / Contenido. Preliminares; Capítulo 1 - Instituciones y partidos; Capítulo 2 - Drogas ilícitas; Capítulo 3 - Política y economía; Capítulo 4 - Política social y conflicto; Anexos

Quality control in the subject "clínica odontológica integrada". Creation of new evaluation methodologies and chek-list type self-assessment to minimize cognitive errors in dental practice teaching

Evaluación, autoevaluación y control de calidad de la asistencia clínica mediante herramientas tipo check-list. Transferencia y aplicación de experiencias positivas en la enseñanza de la Clínica Odontológica Integrada Infantil.The present project arises from the necessity of improvement in the clinical care of the subject Clínica Odontológica Integrada, which is taken by students from the last two years of the Degree in Dentistry. The increase in positive motivation of the patients and their families during the operative procedures will generate a greater perception of the quality of attention. We have checked the obvious difficulty for students to realize the needs arised in the clinic when patients are treated.Depto. de Especialidades Clínicas OdontológicasFac. de OdontologíaFALSEsubmitte

A single nucleotide polymorphism uncovers a novel function for the transcription factor Ace2 during Candida albicans hyphal development

Candida albicans is a major invasive fungal pathogen in humans. An important virulence factor is its ability to switch between the yeast and hyphal forms, and these filamentous forms are important in tissue penetration and invasion. A common feature for filamentous growth is the ability to inhibit cell separation after cytokinesis, although it is poorly understood how this process is regulated developmentally. In C. albicans, the formation of filaments during hyphal growth requires changes in septin ring dynamics. In this work, we studied the functional relationship between septins and the transcription factor Ace2, which controls the expression of enzymes that catalyze septum degradation. We found that alternative translation initiation produces two Ace2 isoforms. While full-length Ace2, Ace2L, influences septin dynamics in a transcription-independent manner in hyphal cells but not in yeast cells, the use of methionine-55 as the initiation codon gives rise to Ace2S, which functions as the nuclear transcription factor required for the expression of cell separation genes. Genetic evidence indicates that Ace2L influences the incorporation of the Sep7 septin to hyphal septin rings in order to avoid inappropriate activation of cell separation during filamentous growth. Interestingly, a natural single nucleotide polymorphism (SNP) present in the C. albicans WO-1 background and other C. albicans commensal and clinical isolates generates a stop codon in the ninth codon of Ace2L that mimics the phenotype of cells lacking Ace2L. Finally, we report that Ace2L and Ace2S interact with the NDR kinase Cbk1 and that impairing activity of this kinase results in a defect in septin dynamics similar to that of hyphal cells lacking Ace2L. Together, our findings identify Ace2L and the NDR kinase Cbk1 as new elements of the signaling system that modify septin ring dynamics in hyphae to allow cell-chain formation, a feature that appears to have evolved in specific C. albicans lineages

Festival Juvenil de Teatro Grecolatino de Segóbriga : historia, actividades, dimensión educativa del festival, guías didácticas y trabajos escolares

Resumen tomado de la publicaciónLos profesores asturianos de lenguas clásicas pretenden acercar el teatro clásico a los escolares. Estructurada en cuatro apartados (Historia y actividades del festival; Dimensión educativa del festival; Guías didácticas; Trabajos escolares premiados en la sede de Gijón),la publicación repasa las actividades que el festival ha llevado a cabo en sus trece años de existencia, presenta veintisiete guías didácticas con el fin de facilitar y ahondar en la lectura de los escritores grecolatinos en el aula y recoge los trabajos realizados por alumnos de ESO y bachillerato premiados en los concursos que cada primavera convoca este Festival.AsturiasUniversidad de Oviedo. Facultad de Ciencias de la Educación; Calle Aniceto Sela s. n.; 33005 Oviedo; +34985103215; +34985103214;ES