Irradiation Tests for Commercial Off-the Shelf Components with Atmospheric-like Neutrons and Heavy-Ions

This paper presents the results of the irradiation, performed with atmospheric-like neutrons and heavy-ions, of Commercial Off-the Shelf Components (COTS), which can be used in space missions. In such cases, it is crucial to perform tests in a radiation environment that emulates the environment of different orbits around Earth. In our study we used atmosphericlike neutrons with fluences up to 1011 neutrons/cm-2 and Kr ions of fluences up to 107 ions/cm-2. These intensities are augmented with respect to the atmospheric one in order to shorten the irradiation time while simulating a long-time exposure during a possible mission in Low Earth Orbit (LEO). A similar radiation environment to LEO can also be present during High-Energy Physics experiments. Therefore, the study herby reported can also be helpful for accelerator physics. In this paper we show in detail procedures, setup and results we have obtained on a commercial device normally exploited in automotive environments.Comment: 9 pages, 10 figures, 7 table

Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma

Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Short-wave infrared imaging (SWIR) has advantages over conventional near-infrared I (NIR-I) imaging with reduced tissue scattering and autofluorescence. Here, two NIR-I dyes (IRDye800CW and IR12), with long tails emitting in the SWIR range, were conjugated with a clinical-grade anti-GD2 monoclonal antibody (Dinutuximab-beta) to compare NIR-I and SWIR imaging for neuroblastoma surgery. A first-of-its-kind multispectral NIR-I/SWIR fluorescence imaging device was constructed to allow an objective comparison between the two imaging windows. Conjugates were first characterized in vitro. Tissue-mimicking phantoms, imaging specimens of known geometric and material composition, were used to assess the sensitivity and depth penetration of the NIR-I/SWIR device, showing a minimum detectable volume of ~0.9 mm3 and depth penetration up to 3 mm. In vivo, fluorescence imaging using the NIR-I/SWIR device showed a high tumor-to-background ratio (TBR) for both dyes, with anti-GD2-IR800 being significantly brighter than anti-GD2-IR12. Crucially, the system enabled higher TBR at SWIR wavelengths than at NIR-I wavelengths, verifying SWIR imaging enables high-contrast delineation of tumor margins. This work demonstrates that by combining the high-specificity of anti-GD2 antibodies with the availability and translatability of existing NIR-I dyes, along with the advantages of SWIR in terms of depth and tumor signal-to-background ratio, GD2-targeted NIR-I/SWIR-guided surgery could improve the treatment of neuroblastoma patients, warranting investigation in future clinical trials

The Gamma-Flash data acquisition system for observation of terrestrial gamma-ray flashes

Gamma-Flash is an Italian project funded by the Italian Space Agency (ASI) and led by the National Institute for Astrophysics (INAF), devoted to the observation and study of high-energy phenomena, such as terrestrial gamma-ray flashes and gamma-ray glows produced in the Earth's atmosphere during thunderstorms. The project's detectors and the data acquisition and control system (DACS) are placed at the "O. Vittori" observatory on the top of Mt. Cimone (Italy). Another payload will be placed on an aircraft for observations of thunderstorms in the air. This work presents the architecture of the data acquisition and control system and the data flow.Comment: 4 pages, 1 figure, Astronomical Data Analysis Software and System XXXII (2022

The clinical effectiveness of an integrated multidisciplinary evidence-based program to prevent intraoperative pressure injuries in high-risk children undergoing long-duration surgical procedures: a quality improvement study

The prevention of hospital-acquired pressure injuries (HAPIs) in children undergoing long-duration surgical procedures is of critical importance due to the potential for catastrophic sequelae of these generally preventable injuries for the child and their family. Long-duration surgical procedures in children have the potential to result in high rates of HAPI due to physiological factors and the difficulty or impossibility of repositioning these patients intraoperatively. We developed and implemented a multi-modal, multi-disciplinary translational HAPI prevention quality improvement program at a large European Paediatric University Teaching Hospital. The intervention comprised the establishment of wound prevention teams, modified HAPI risk assessment tools, specific education, and the use of prophylactic dressings and fluidized positioners during long-duration surgical procedures. As part of the evaluation of the effectiveness of the program in reducing intraoperative HAPI, we conducted a prospective cohort study of 200 children undergoing long-duration surgical procedures and compared their outcomes with a matched historical cohort of 200 children who had undergone similar surgery the previous year. The findings demonstrated a reduction in HAPI in the intervention cohort of 80% (p < 0.01) compared to the comparator group when controlling for age, pathology, comorbidity, and surgical duration. We believe that the findings demonstrate that it is possible to significantly decrease HAPI incidence in these highly vulnerable children by using an evidence-based, multi-modal, multidisciplinary HAPI prevention strategy

Multimodality Imaging for Diagnosis and Characterization of a Cardiac Hydatid Cyst

Here, we report the case of a young patient admitted to the emergency department because of abdominal pain. Computed tomography revealed a mass within her right heart. Through serial multimodality imaging testing, including computed tomography, three-dimensional (2D)- and three-dimensional echocardiography, as well as cardiac magnetic resonance, the diagnosis of cardiac involvement in the course of Echinococcus granulosus infection was hypothesized

Proliferative Fasciitis of the Hand in a Nine-Year-Old Girl: A Case Report and Review of the Literature

info:eu-repo/semantics/publishe