Steady state fluctuation relations for systems driven by an external random force

We experimentally study the fluctuations of the work done by an external Gaussian random force on two different stochastic systems coupled to a thermal bath: a colloidal particle in an optical trap and an atomic force microscopy cantilever. We determine the corresponding probability density functions for different random forcing amplitudes ranging from a small fraction to several times the amplitude of the thermal noise. In both systems for sufficiently weak forcing amplitudes the work fluctuations satisfy the usual steady state fluctuation theorem. As the forcing amplitude drives the system far from equilibrium, deviations of the fluctuation theorem increase monotonically. The deviations can be recasted to a single master curve which only depends on the kind of stochastic external force.Comment: 6 pages, submitted to EP

Entropy production and fluctuation theorems under feedback control: the molecular refrigerator model revisited

We revisit the model of a Brownian particle in a heat bath submitted to an actively controlled force proportional to the velocity that leads to thermal noise reduction (cold damping). We investigate the influence of the continuous feedback on the fluctuations of the total entropy production and show that the explicit expression of the detailed fluctuation theorem involves different dynamics and observables in the forward and backward processes. As an illustration, we study the analytically solvable case of a harmonic oscillator and calculate the characteristic function of the entropy production in a nonequilibrium steady state. We then determine the corresponding large deviation function which results from an unusual interplay between 'boundary' and 'bulk' contributions.Comment: 16 pages, 5 figures. References 9,10,13,14,15 added. A few changes in the text. Accepted for publication in J. Stat. Mec

VHCF response of heat-treated SLM Ti6Al4V Gaussian specimens with large loaded volume

Abstract Among the materials used for the production of components through Additive Manufacturing (AM) processes, the Selective-Laser-Melting (SLM) Ti6Al4V alloy is widely employed in aerospace applications for its high specific strength and in biomedical applications for its good biocompatibility. Actual structural applications are generally limited to static loading conditions where the large defects originating during the SLM process do not play a significant role for the static failure. On the contrary, the same defects strongly affect the fatigue response of the parts since they act as crack initiation sites that rapidly lead to fatigue failure. In the literature, a lot of research has been carried out to investigate the quasi-static and the High-Cycle Fatigue properties of the SLM Ti6Al4V alloy but there are still few studies on its Very-High-Cycle Fatigue (VHCF) response. In the paper, the VHCF response of Ti6Al4V specimens, which are vertically orientated during the SLM building and then subjected to a conventional heat treatment (2 hours heating in vacuum at 850°C), is experimentally assessed. Ultrasonic VHCF tests are carried out on Gaussian specimens with a large risk-volume (2300 mm3). Fracture surfaces are investigated for revealing the defect originating the fatigue failure. The Stress Intensity Factor Threshold associated to the experimental failures is finally estimated

Carbon nanotubes adhesion and nanomechanical behavior from peeling force spectroscopy

Applications based on Single Walled Carbon Nanotube (SWNT) are good example of the great need to continuously develop metrology methods in the field of nanotechnology. Contact and interface properties are key parameters that determine the efficiency of SWNT functionalized nanomaterials and nanodevices. In this work we have taken advantage of a good control of the SWNT growth processes at an atomic force microscope (AFM) tip apex and the use of a low noise (1E-13 m/rtHz) AFM to investigate the mechanical behavior of a SWNT touching a surface. By simultaneously recording static and dynamic properties of SWNT, we show that the contact corresponds to a peeling geometry, and extract quantities such as adhesion energy per unit length, curvature and bending rigidity of the nanotube. A complete picture of the local shape of the SWNT and its mechanical behavior is provided

Microstructure and preliminary fatigue analysis on AlSi10Mg samples manufactured by SLM

Nowadays, selective laser melting (SLM) is considered as the most challenging technology for manufacturing complex components in different industrial fields, such as biomedical, aerospace and racing. It is well-known that SLM may yield to microstructures significantly different from those obtained by conventional casting, thus affecting the mechanical properties of the component. In the present paper, microstructural and mechanical tests were carried out on AlSi10Mg samples manufactured by SLM technique in the XY building configuration. Homogeneous composition and typical microstructures were achieved for all the investigated samples. The mechanical properties were assessed through a tensile test and through the Impulse Excitation Technique (IET). The feasibility of ultrasonic Very High Cycle Fatigue (VHCF) tests with Gaussian specimens characterized by large loaded volumes (risk-volumes) was also experimentally verified in the paper. A Gaussian specimen was designed and manufactured. A preliminary ultrasonic test was then carried out on the manufactured specimen and the fracture surface was finally investigated

Frequency dependence of viscous and viscoelastic dissipation in coated micro-cantilevers from noise measurement

We measure the mechanical thermal noise of soft silicon atomic force microscopy cantilevers. Using an interferometric setup, we have a resolution down to 1E-14 m/rtHz on a wide spectral range (3 Hz to 1E5 Hz). The low frequency behavior depends dramatically on the presence of a reflective coating: almost flat spectrums for uncoated cantilevers versus 1/f like trend for coated ones. The addition of a viscoelastic term in models of the mechanical system can account for this observation. Use of Kramers-Kronig relations validate this approach with a complete determination of the response of the cantilever: a power law with a small coefficient is found for the frequency dependence of viscoelasticity due to the coating, whereas the viscous damping due to the surrounding atmosphere is accurately described by the Sader model

Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy.

Pegylation of nanoparticles has been widely implemented in the field of drug delivery to prevent macrophage clearance and increase drug accumulation at a target site. However, the shielding effect of polyethylene glycol (PEG) is usually incomplete and transient, due to loss of nanoparticle integrity upon systemic injection. Here, we have synthesized unique PEG-dendron-phospholipid constructs that form super stealth liposomes (SSLs). A \u3b2-glutamic acid dendron anchor was used to attach a PEG chain to several distearoyl phosphoethanolamine lipids, thereby differing from conventional stealth liposomes where a PEG chain is attached to a single phospholipid. This composition was shown to increase liposomal stability, prolong the circulation half-life, improve the biodistribution profile and enhance the anticancer potency of a drug payload (doxorubicin hydrochloride)

Charged membrane as a source for repulsive gravity

We demonstrate an alternative (with respect to the ones existing in literature) and more habitual for physicists derivation of exact solution of the Einstein-Maxwell equations for the motion of a charged spherical membrane with tangential tension. We stress that the physically acceptable range of parameters for which the static and stable state of the membrane producing the Reissner-Nordstrom (RN) repulsive gravity effect exists. The concrete realization of such state for the Nambu-Goto membrane is described. The point is that membrane are able to cut out the central naked singularity region and at the same time to join in appropriate way the RN repulsive region. As result we have a model of an everywhere-regular material source exhibiting a repulsive gravitational force in the vicinity of its surface: this construction gives a more sensible physical status to the RN solution in the naked singularity case.Comment: Accepted for publication in IJMPD, 17-07-2008; 16 pages, 1 figur