8 research outputs found
HLA-haploidentical allografting with high-dose post-transplant cyclophosphamide: clinical outcomes and immunereconstitution.
Hematopoietic stem and progenitor cell composition in peripheral blood and in mobilized CD34+ cells harvests.
CLINICAL IMPACT OF IMMUNOPHENOTYPIC REMISSION AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION IN MULTIPLE MYELOMA
Prospective molecular monitoring of minimal residual disease after nonmyeloablative allografting in newly diagnosed multiple myeloma
High Rates of Prolonged Molecular Remissions After Tandem Autologous-Nonmyeloablative Allografting in Newly Diagnosed Myeloma
High Rates of Prolonged Molecular Remissions After Tandem Autologous-Nonmyeloablative Allografting in Newly Diagnosed Myeloma
MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
Abnormal activation of MET/HGF (Hepatocyte Growth Factor) pathway has been described in several tumours and increased HGF plasmatic levels have been detected in patients with aggressive multiple myeloma (MM). MET and HGF mRNA expression was investigated in 105 samples of purified plasma cells derived from newly diagnosed MM patients treated with bortezomib-based induction therapy. Gene expression was compared with response to therapy and clinical outcome. MET gene copy number was also evaluated. MET mRNA expression was higher in CD138+ than in CD138- cells (median 76\ub790 vs. 11\ub724; P = 0\ub70009). Low MET mRNA expression characterized patients with better response (complete response or very good partial response) compared to other patients (median 56\ub710 vs. 134\ub783; P = 0\ub70006). After a median follow-up of 50 months, patients with high MET mRNA expression displayed a worse progression-free survival (PFS; P = 0\ub70029) and overall survival (OS; P = 0\ub70023) compared to those with low MET mRNA levels. Patients with both high MET mRNA expression and high \u3b22-microglobulin level (>5\ub75 mg/l) had further worse median PFS (P < 0\ub70001) and OS (P < 0\ub70001). Patients carrying 4 MET gene copies (8 out of 82, 9\ub78%) also had a short PFS. High MET mRNA expression identifies patients with dismal PFS and OS and the combination with high \u3b22-microglobulin further characterizes patients with worse outcome