BIOMECHANICS ANALYSIS OF WATER POLO THROWING

The purpose of this study is to investigate the parameters of displacement. velocity, and acceleration of water polo over arm throwing. Six water polo athletes participated in this study. Kwon 3D was utilized to analyze arm movement of water polo shooting, including the displacement, velocity, and acceleration of wrist, elbow, shoulder, and ball. The results indicated, first, the displacement of arm movement was quadratic polynomial at a frequency of 0.6 second with maximum distance of 130.97 cm for ball, 117.17 cm for wrist, 107.04 cm for elbow, and 94.22 cm for shoulder. Second, the velocity of arm movement was a cubic curve with maximum speed of 25.368 m/s for ball, 20.092 m/s for wrist, 19.732 rn/s for elbow, and 23.846 m/s for shoulder. Moreover, the change of maximum velocity of ball and wrist occurred after 1.5 seconds, while the velocity of elbow and shoulder both decreased for 0.5 seconds. Third, the acceleration of arm movement showed a 6th order polynomial at a frequency of 0.2 second with maximum acceleration of 505.082 m/s2 for ball, 545.526 m/s2 for wrist, 401.82 m/s2 for elbow, and 568.26 m/s2 for shoulder

Ring Chromosome 7 Presenting with Intrauterine Growth Restriction and Multiple Anomalies

SummaryObjectiveRing chromosome 7 is a very rare chromosomal anomaly that may have a grave prognosis. Nevertheless, the clinical features associated with ring chromosome 7 are highly variable. Here, we report a case with ring chromosome 7 and the perinatal findings.Case ReportA 32-year-old, gravida 1, para 0, woman was referred to our hospital because of intrauterine growth restriction (IUGR) and oligohydramnios at 35 weeks of gestation. Prenatal ultrasound revealed a severe IUGR fetus presenting with multicystic kidney, hydronephrosis and oligohydramnios. At parturition, the birth weight of this male infant was 1,720 g, and a battery of anomalies were also noted, including imperforate anus, hypospadia, micropenis, right cryptorchidism, severe IUGR, multiple nevi on the forehead, shoulder and left thigh, brain atrophy, right multicystic kidney, and left mild hydronephrosis. Cytogenetic study from cord blood revealed a ring chromosome 7.ConclusionRing chromosome 7 is extremely rare and our case might be the 15th and youngest case in the medical literature. Our case had multicystic kidney and imperforate anus, which have not been reported previously. Prenatal diagnosis of ring chromosome 7 is very difficult. When fetuses present with severe IUGR, oligohydramnios and multicystic kidney, chromosomal aberrations should be kept in mind, and perinatal cytogenetic workup is warranted

THE EFFECT OF PLYOMETRIC TRAINING FOR LOWER EXTREMITIES STRENGTH AND POWER IN HIGH-SCHOOL FEMALE BASKETBALL PLAYERS

Plyometric training is one of very prevailing training methods. It has its unique effect compared to other training methods. Having targeted 16 girl basketball players in senior high school, a set of box horse curriculum was designed with polymetric training for the study. The players were randomly divided into experimental groups (respectively with 30, 40, and 50 cm of box horse) and control group, four players for each group. Except for the control group, the other three groups had to receive 12 weeks of box horse training in addition to general basketball course training. The results of the study showed: Based on the plyometric training designed and applied to senior high school girl basketball players, this study shows that either CMJ or CJ has its effect

Efectos sobre la gestión del conocimiento y la cultura corporativa en el clima de innovación organizativa

El conocimiento y la innovación se consideran rasgos característicos de la nueva era de la economía del conocimiento. Toda organización debe ser capaz de gestionar el conocimiento y de innovar continuamente para hacer patentes sus ventajas competitivas. Sometidas a una creciente competencia de mercado, las empresas dependen cada vez más de la innovación para aumentar la competitividad que les permita sobrevivir y desarrollarse. Un clima de innovación organizativa desempeña por ello un papel central en la ejecución de operaciones y actividades. A tenor de los motivos y propósitos de investigaciones previas, en este estudio se pretende discutir la correlación entre el clima de innovación organizativa y la gestión del conocimiento. Nuestro objeto de investigación se centra en una muestra de trabajadores manuales del parque industrial de Linkou a los que se distribuye 650 cuestionarios. Una vez eliminados los cuestionarios que no eran válidos o los incompletos, se obtienen 348 válidos, con una tasa de recuperación del 54%. Los resultados empíricos muestran lo siguiente: 1. Se produce una correlación parcialmente significativa entre la gestión del conocimiento y la cultura corporativa. 2. Se da una considerable correlación entre cultura corporativa y clima de innovación organizativa. 3 Asimismo, se produce una notable correlación entre gestión del conocimiento y cultura corporativa. 4. Hay un efecto de mediación entre la cultura corporativa relacionada con la gestión del conocimiento y el clima de innovación organizativa.Knowledge and innovation are regarded as characteristics in the new knowledge economy era. Any organization should be able to manage knowledge and continuously innovate in order to present their competitive advantages. Under increasing market competition, enterprises depend more on innovation to enhance the competitiveness for survival and development. Organizational Innovation Climate therefore plays a critical role in the overall operation and activity performance. According to the previous research motives and purposes, this study aims to discuss the correlations between Organizational Innovation Climate and Knowledge Management. Manufacturers in Linkou Industrial Park are sampled as the research subjects and a total of 650 questionnaires are distributed. Having eliminated invalid and incomplete questionnaires, a total of 348 valid copies are retrieved, with a retrieval rate of 54%. The empirical results show 1. Partially significant correlations between Knowledge Management and Corporate Culture, 2. Remarkable correlations between Corporate Culture and Organizational Innovation Climate, 3. Notable correlations between Knowledge Management and Corporate Culture, and 4. Mediating effects of Corporate Culture on Knowledge Management and Organizational Innovation Climate

SEPTIN12 Genetic Variants Confer Susceptibility to Teratozoospermia

It is estimated that 10–15% of couples are infertile and male factors account for about half of these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men have been able to father offspring. However, teratozoospermia still remains a big challenge to tackle. Septins belong to a family of cytoskeletal proteins with GTPase activity and are involved in various biological processes e.g. morphogenesis, compartmentalization, apoptosis and cytokinesis. SEPTIN12, identified by c-DNA microarray analysis of infertile men, is exclusively expressed in the post meiotic male germ cells. Septin12+/+/Septin12+/− chimeric mice have multiple reproductive defects including the presence of immature sperm in the semen, and sperm with bent neck (defect of the annulus) and nuclear DNA damage. These facts make SEPTIN12 a potential sterile gene in humans. In this study, we sequenced the entire coding region of SEPTIN12 in infertile men (n = 160) and fertile controls (n = 200) and identified ten variants. Among them is the c.474 G>A variant within exon 5 that encodes part of the GTP binding domain. The variant creates a novel splice donor site that causes skipping of a portion of exon 5, resulting in a truncated protein lacking the C-terminal half of SEPTIN12. Most individuals homozygous for the c.474 A allele had teratozoospermia (abnormal sperm <14%) and their sperm showed bent tail and de-condensed nucleus with significant DNA damage. Ex vivo experiment showed truncated SEPT12 inhibits filament formation in a dose-dependent manner. This study provides the first causal link between SEPTIN12 genetic variant and male infertility with distinctive sperm pathology. Our finding also suggests vital roles of SEPT12 in sperm nuclear integrity and tail development

Women with endometriosis have higher comorbidities: Analysis of domestic data in Taiwan

AbstractEndometriosis, defined by the presence of viable extrauterine endometrial glands and stroma, can grow or bleed cyclically, and possesses characteristics including a destructive, invasive, and metastatic nature. Since endometriosis may result in pelvic inflammation, adhesion, chronic pain, and infertility, and can progress to biologically malignant tumors, it is a long-term major health issue in women of reproductive age. In this review, we analyze the Taiwan domestic research addressing associations between endometriosis and other diseases. Concerning malignant tumors, we identified four studies on the links between endometriosis and ovarian cancer, one on breast cancer, two on endometrial cancer, one on colorectal cancer, and one on other malignancies, as well as one on associations between endometriosis and irritable bowel syndrome, one on links with migraine headache, three on links with pelvic inflammatory diseases, four on links with infertility, four on links with obesity, four on links with chronic liver disease, four on links with rheumatoid arthritis, four on links with chronic renal disease, five on links with diabetes mellitus, and five on links with cardiovascular diseases (hypertension, hyperlipidemia, etc.). The data available to date support that women with endometriosis might be at risk of some chronic illnesses and certain malignancies, although we consider the evidence for some comorbidities to be of low quality, for example, the association between colon cancer and adenomyosis/endometriosis. We still believe that the risk of comorbidity might be higher in women with endometriosis than that we supposed before. More research is needed to determine whether women with endometriosis are really at risk of these comorbidities

Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers

Despite many evidences supporting the concept of “oncogene addiction” and many hypotheses rationalizing it, there is still a lack of detailed understanding to the precise molecular mechanism underlying oncogene addiction. In this account, we developed a mathematic model of epidermal growth factor receptor (EGFR) associated signaling network, which involves EGFR-driving proliferation/pro-survival signaling pathways Ras/extracellular-signal-regulated kinase (ERK) and phosphoinositol-3 kinase (PI3K)/AKT, and pro-apoptotic signaling pathway apoptosis signal-regulating kinase 1 (ASK1)/p38. In the setting of sustained EGFR activation, the simulation results show a persistent high level of proliferation/pro-survival effectors phospho-ERK and phospho-AKT, and a basal level of pro-apoptotic effector phospho-p38. The potential of p38 activation (apoptotic potential) due to the elevated level of reactive oxygen species (ROS) is largely suppressed by the negative crosstalk between PI3K/AKT and ASK1/p38 pathways. Upon acute EGFR inactivation, the survival signals decay rapidly, followed by a fast increase of the apoptotic signal due to the release of apoptotic potential. Overall, our systems biology modeling together with experimental validations reveals that inhibition of survival signals and concomitant release of apoptotic potential jointly contribute to the tumor cell death following the inhibition of addicted oncogene in EGFR addicted cancers