1 research outputs found
Gut microbiota and COVIDâ19: A systematic review
Abstract Background and Aims Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirusâ2 (SARSâCoVâ2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARSâCoVâ2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARSâCoVâ2 infection and its severity and the impact that SARSâCoVâ2 could have on the gut microbiota. Methods We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then fullâtext screening. The data of the eligible studies were extracted into a preâdesigned word table. This study adhered to the PRISMA checklist and NewcastleâOttawa Scale Bias Assessment tool. Results Sixtyâthree publications were included in this review. Our study shows that among COVIDâ19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVIDâ19 disease would probably also be influenced by the gut, and lung microbiota's composition. Conclusion Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVIDâ19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVIDâ19 and human microbiome