1,980 research outputs found

    Cascade Residual Learning: A Two-stage Convolutional Neural Network for Stereo Matching

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    Leveraging on the recent developments in convolutional neural networks (CNNs), matching dense correspondence from a stereo pair has been cast as a learning problem, with performance exceeding traditional approaches. However, it remains challenging to generate high-quality disparities for the inherently ill-posed regions. To tackle this problem, we propose a novel cascade CNN architecture composing of two stages. The first stage advances the recently proposed DispNet by equipping it with extra up-convolution modules, leading to disparity images with more details. The second stage explicitly rectifies the disparity initialized by the first stage; it couples with the first-stage and generates residual signals across multiple scales. The summation of the outputs from the two stages gives the final disparity. As opposed to directly learning the disparity at the second stage, we show that residual learning provides more effective refinement. Moreover, it also benefits the training of the overall cascade network. Experimentation shows that our cascade residual learning scheme provides state-of-the-art performance for matching stereo correspondence. By the time of the submission of this paper, our method ranks first in the KITTI 2015 stereo benchmark, surpassing the prior works by a noteworthy margin.Comment: Accepted at ICCVW 2017. The first two authors contributed equally to this pape

    Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

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    The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target. Gp120 has remarkably high levels of N-linked glycosylation and there is considerable evidence that this “glycan shield” can help protect the virus from antibody-mediated neutralization. In recent years, however, it has become clear that gp120 glycosylation can also be included in the targets of recognition by some of the most potent broadly neutralizing antibodies. Knowing the site-specific glycosylation of gp120 can facilitate the rational design of glycopeptide antigens for HIV vaccine development. While most prior studies have focused on glycan analysis of recombinant forms of gp120, here we report the first systematic glycosylation site analysis of gp120 derived from virions produced by infected T lymphoid cells and show that a single site is exclusively substituted with complex glycans. These results should help guide the design of vaccine immunogens

    Action learning to improve nursing students’ capacity in disaster preparedness

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    2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    Raman scattering and X-ray diffraction study of neutron irradiated GaN epilayers

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    Neutron irradiation induced defects and their effects on the carrier concentration of GaN epilayers are investigated with Raman scattering and X-ray diffraction techniques. Relative to the as-grown sample, the neutronirradiated samples exhibit a clear variation in the position and lineshape of the A 1(LO)-mode Raman peak as well as in the fullwidth at half-maximum height (FWHM) of the XRD rocking curves. Careful curve fitting and adequate calculations give the carrier concentrations of the irradiated GaN. It is found that the defects induced by neutron irradiation act as carrier trap centres which capture the electron carriers so that the carrier concentration of the irradiated GaN is reduced. © 2005 IEEE.published_or_final_versio

    Severe childhood malaria syndromes defined by plasma proteome profiles

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    BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood. Therefore it is important to understand the pathology underlying the development of CM and SMA, as opposed to uncomplicated malaria (UM). Different host responses to infection are likely to be reflected in plasma proteome-patterns that associate with clinical status and therefore provide indicators of the pathogenesis of these syndromes. METHODS AND FINDINGS Plasma and comprehensive clinical data for discovery and validation cohorts were obtained as part of a prospective case-control study of severe childhood malaria at the main tertiary hospital of the city of Ibadan, an urban and densely populated holoendemic malaria area in Nigeria. A total of 946 children participated in this study. Plasma was subjected to high-throughput proteomic profiling. Statistical pattern-recognition methods were used to find proteome-patterns that defined disease groups. Plasma proteome-patterns accurately distinguished children with CM and with SMA from those with UM, and from healthy or severely ill malaria-negative children. CONCLUSIONS We report that an accurate definition of the major childhood malaria syndromes can be achieved using plasma proteome-patterns. Our proteomic data can be exploited to understand the pathogenesis of the different childhood severe malaria syndromes

    Predicting pressure sore risk with the Braden(modified),Norton and WCUMS Scales

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    2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
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