Research progress in intravesical instillation for non-muscle invasive bladder cancer

Bladder cancer is the most common malignant tumor of the urinary system， which seriously affects patients’ health and life. Transurethral resection of bladder tumor is the main treatment for non-muscle invasive bladder cancer （NMIBC）， whereas high recurrence rate after surgery remains the main challenge. To prevent tumor recurrence， intravesical instillation is often performed postoperatively by clinicians. In this article， traditional intravesical instillation， new drugs and therapeutic regimens were illustrated and summarized， aiming to provide valuable reference for clinical treatment of NMIBC

Progress in immune checkpoint inhibitor-based combined regimens in the treatment of metastatic urothelial carcinoma

Metastatic urothelial carcinoma （mUC） yields poor prognosis and is difficult to treat. Immunotherapy strategies have developed rapidly in recent years， and clinical prognosis of mUC patients has been significantly improved. However， immune checkpoint inhibitors （ICIs） alone have limited efficacy， and some ICIs monotherapy indications for mUC have also been withdrawn in recent years. Therefore， combined therapy based on ICIs has become a research hotspot in the treatment of mUC. At present， multiple clinical studies of ICIs combined with chemotherapy， antibody-drug conjugates， and dual immunotherapy for multiple lines of treatment of mUC have proved that combined therapy possesses promising development prospect. In this article， latest progress in ICI-based combined treatment for mUC was reviewed， aiming to provide reference for clinicians

Performance Diagnosis and Analysis of a Thermal Power Turbine Unit in a Power Plant

In order to further improve the operation level of the provincial grid direct thermal power units, optimize the data quality of the provincial thermal power unit system, diagnose and analyze the operation data of the thermal power unit system, and comprehensively analyze and evaluate the unit regulation ability from the aspects of heating capacity, the minimum startup mode of the whole plant, and the load capacity of the heating state, so as to provide support for the accurate scheduling of the unit

TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma

BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics data of ccRCC samples were obtained from public databases, and 5 pairs of ccRCC tissue samples were collected from the operating room. Wilcox, chi-square test, Kaplan-Meier method, receiver operating characteristic curve, regression analysis, meta-analysis, and correlation analysis were used to clarify the relationship of TPD52L2 with clinical features, prognosis, and immune microenvironment. Functional enrichment analysis was performed to reveal the potential pathways in which TPD52L2 participates in the progression of ccRCC. The siRNA technique was used to knockdown in the expression level of TPD52L2 in 786-O cells to verify its effect on ccRCC progression.ResultsFirst, TPD52L2 was found to be upregulated in ccRCC at both mRNA and protein levels. Second, TPD52L2 was significantly associated with poor prognosis and served as an independent prognostic factor. Moreover, TPD52L2 expression was regulated by DNA methylation, and some methylation sites were associated with ccRCC prognosis. Third, TPD52L2 overexpression may participate in the pathological process through various signaling pathways such as cytokine-cytokine receptor interactions, PI3K-Akt, IL-17, Wnt, Hippo signaling pathway, and ECM-receptor interactions. Interestingly, TPD52L2 expression level was also closely related to the abundance of various immune cells, immune checkpoint expression, and TMB. Finally, in vitro experiments confirmed that knocking down TPD52L2 can inhibit the proliferation, migration, and invasion abilities of ccRCC cells.ConclusionThis study for the first time revealed the upregulation of TPD52L2 expression in ccRCC, which is closely associated with poor prognosis of patients and is a potentially valuable therapeutic and efficacy assessment target for immunotherapy

Analysis of Heating Transformation of Nuclear Power Units

Under the current national conditions and policy support, nuclear heating has flourished. Domestic nuclear power units mainly generate electricity, and nuclear heating as a clean energy source is one of the main ways to solve winter heating in the north. This paper first compares and analyzes the two different ways of nuclear heating, then takes the nuclear heating of Haiyang Nuclear Power Station as an example, based on the mature experience of steam extraction heating transformation of thermal power units, makes an economic analysis on the steam extraction transformation of PWR nuclear power units from the characteristics of the thermal system combined with the Spot market, and finally makes an economic evaluation on the Cogeneration nuclear power units

The prognostic significance of circulating plasma cells in newly diagnosed multiple myeloma patients

ObjectiveMultiple myeloma (MM) is a highly characteristic tumor that is influenced by numerous factors that determine its prognosis. Studies indicate that the presence of circulating plasma cells (cPCs) is a detrimental factor that significantly impacts the prognosis of patients with MM.MethodsThis study retrospectively analyzed the prognostic value of cPCs quantified by 10-color flow cytometry in 145 newly diagnosed MM (NDMM) cases in the First Affiliated Hospital of Soochow University from November 2018 to February 2021. The study was approved by the Ethics Committee of the hospital (2021 No. 93).ResultsOf the 145 patients, 99 (68.2%) were detected cPCs. Through receiver operating characteristics (ROC) analysis, an optimal threshold of 0.165% was identified as a predictor for overall survival (OS). The median progression-free survival (PFS) was 33 months in patients with cPCs ≥0.165%, whereas those with cPCs <0.165% had a PFS of <33 months (p=0.001). The median OS was not reached for two groups; the 3-year OS for patients with cPCs ≥0.165% was 71% compared with 87% for those with cPCs <0.165% (p=0.003). In transplant patients, cPCs ≥0.165% also predicted worse prognosis. Similarly, when considering cytogenetic risk factors in conjunction with cPC levels, comparable results were obtained. To evaluate whether the Revised International Staging System (R-ISS) groups could be further stratified based on different prognostic factors related to cPCs, our study revealed similar median PFS and OS rates in R-ISS II stage patients with cPCs ≥0.165% compared to those in the III stage (p=0.659 and 0.249, respectively).ConclusionThis study demonstrates that a high ratio of cPCs serves as a reliable indicator for predicting a poorer prognosis in MM cases. Furthermore, incorporating the R-ISS system and cytogenetic risk factors alongside the level of cPCs enhances the accuracy of prognostic predictions for patients with MM

Research on the Application of Operational Optimization Expert Analysis System Technology

At present, the national power system is gradually achieving separation of government and enterprise, and corporate restructuring; Implement the separation of network factories and bidding for online access, and gradually establish a modern enterprise system. Effectively carrying out energy conservation and consumption reduction work, reducing the cost of power generation and supply, is an inevitable requirement for the survival and development of power enterprises themselves.To effectively carry out energy-saving and consumption reduction work, as a group power generation company and power plant, it is necessary to solve the following problems: how to evaluate the actual and expected level of unit performance, how to quantitatively determine the impact of various factors on unit performance, how to improve operational level to reduce energy consumption, how to assess and evaluate the implementation of energy-saving work from a management perspective, and so on. Therefore, it is necessary to have a complete and scientific expert analysis system for optimizing power plant operation

Research on operation of low-pressure cylinder zero output heat supply retrofit unit

This paper introduces the technical route of the zero output heat supply transformation of low pressure cylinders in Shandong Province, the operation after the transformation, the impact on power grid dispatching, and the constraints on the normal operation of some units after the transformation, providing technical support for power generation enterprises to accurately implement the “three transformation linkage” transformation scheme and the accurate dispatching of the power dispatching cente

Diagnosis and Analysis of Thermal Power Plant Operation in Heating Season

In order to further improve the operation level of the thermal power units of the provincial grid thermal power plant, optimize the data quality of the online monitoring system of the provincial thermal power units, through the diagnosis and analysis of the operation data of the thermal power online monitoring system, and from an all-round perspective, analyze and evaluate the peak shaving and frequency modulation capabilities of the heat supply units of the thermal power plant from the aspects of the load carrying capacity of the heat supply units, the optimization of the startup mode of the whole plant, and the heating capacity, to provide support for the accurate scheduling of the heat supply units. This paper analyzes the heat supply, peak regulation and frequency regulation capacity of the whole thermal power plant through the operation data, draws the peak regulation interval and heat supply capacity interval, and provides support for the optimal operation of the whole plant

Prospect of Peak Regulation Capacity Improvement through Flexibility Transformation of Combined Heat and Power Units in Shandong Province

With the high proportion of renewable energy connected to the grid, peak shaving demand surge, which needs to enhance the flexibility of coal power with a larger proportion to support the stable operation of the grid. At present, the capacity of the combined heat and power unit accounts for about 87 % of direct dispatching coal-fired power plants by Shandong power grid. The flexible operation ability of the combined heat and power unit is poor, and its flexible transformation is urgent. This paper summarizes the current relatively mature flexibility transformation technology of combined heat and power unit, including low pressure cylinder zero output transformation (cylinder cutting transformation), bypass load regulation, thermal energy storage and electrical energy storage transformation technology, and puts forward to encourage the flexibility transformation of in-service combined heat and power unit, and actively promote the research and application of the intelligent heating network, the integration of thermal and electricity, and the clean heating construction and clean heating technology