4 research outputs found
Biodiversity of the human oral mycobiome in health and disease
The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and highâthroughput sequencing such as nextâgeneration sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral cohabituĂ©s. Their diversity is perplexing, and functionality yet to be deciphered. Here, we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives
Assessment of cell sheet constructs with periodontal ligament stem cells and endothelial cells for periodontal regeneration
abstractDentistryDoctoralDoctor of Philosoph