An effective method of accelerating Bose gases using magnetic coils

This is the accepted manuscript. The final published version is available from IOP at http://iopscience.iop.org/1674-1056/23/9/093701.Based on the experimental device which is a non-uniform magnetic field to trap an atom, we show how to obtain a certain velocity of a Bose gas by controlling the magnetic coils. By comparing the relationship of different current supply and delay time versus the ultimate velocity of the atom,we theoretically predict the method of accelerating the gases to an expected velocity. This method is of great convenience and significance for the applications in cold atom physics and precision measurements.This work is supported by the National Fundamental Research Program of China under Grant No. 2011CB921501

6-Benzyl-3-[(6-chloro­pyridin-3-yl)meth­yl]-6,7-dihydro-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-imine

The title compound, C17H14ClN7, crystallizes with two independent mol­ecules in the asymmetric unit. Inter­molecular N—H⋯N and C—H⋯N hydrogen bonds contribute to the stability of the crystal structure. In addition, weak C—H⋯π and π–π stacking [centroid–centroid distances of 3.699 (8) and 3.699 (6) Å] interactions are observed

Seasonal variation in systemic lupus erythematosus and rheumatoid arthritis: an ecological study In based on internet searches

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which immune regulation is disrupted and characterized by intense inflammation and damage to multiple organs or systems. Rheumatoid arthritis (RA) is another systemic autoimmune disease characterized by chronic synovial joint inflammation that leads to disability and poor quality of life. Although the etiologies and pathogenesis of SLE and RA are not fully understood, it is generally accepted that they are both caused by interactions between genetic and environmental factors. In recent years, emerging studies have demonstrated the potential role of seasonality in the development and disease activity of variety of autoimmune diseases [[1], [2], [3]]

Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia

<p>Abstract</p> <p>Background</p> <p>Capillary leak syndrome (CLS) is a rare condition characterized by recurrent episodes of generalized edema and severe hypotension associated with hypoproteinemia. Interleukin-11 (IL-11) is a promising therapeutic agent for thrombocytopenia. A direct correlation between IL-11 and CLS has never been reported previously, particularly in patients with hepatic carcinoma.</p> <p>Case presentation</p> <p>We describe two cases of CLS after IL-11 administration in two males with thrombocytopenia. Case 1 was a 46-year-old man with recurrence of hepatic carcinoma who was treated with IL-11 (3 mg per day). After four days of therapy, hypotension and hypoproteinemia were detected. The chest X-ray and B ultrasound of the abdomen showed pleural effusion and ascites. IL-11 was then discontinued, fluid resuscitation was performed, and fresh frozen plasma and packed red blood cells were transfused into this patient. The patient had recovered after 19 days of treatment.</p> <p>Case 2 was a 66-year-old man who had undergone radiofrequency ablation (RFA) for hepatic carcinoma. He was treated with IL-11 (3 mg per day) for thrombocytopenia. After two days of therapy, this patient complained of dyspnea with bilateral edema of the hands. Laboratory values showed hypoproteinemia. IL-11 was stopped and human albumin was transfused at a rate of 10 g per day. On the 4^thday, fluid resuscitation was performed. The patient had recovered after treatment for two weeks.</p> <p>Conclusions</p> <p>The detection of IL-11-induced CLS supports the hypothesis that CLS could be a severe side effect of IL-11 treatment in some patients. These two case reports also demonstrate that patients with hepatic carcinoma who experience this rare form of CLS after treatment with IL-11 seem to respond to a therapeutic regimen that involves hydroxyethyl starch, albumin, and diuretic therapy. Liver cancer patients might be more susceptible to CLS because of poor liver function and hypersplenia. In addition, bleeding after RFA might be a further inducer of CLS.</p

4-(3-Carb­oxy­phen­yl)pyridinium nitrate

In the title salt, C12H10NO2 +·NO3 −, the dihedral angle between the pyridine ring and the benzene ring of the 4-(3-carb­oxy­phen­yl)pyridinium cation is 30.14 (2)°. Inversion-related pairs of cations are linked into dimers by pairs of O—H⋯O hydrogen bonds. Pairs of dimers are linked by N—H⋯O and C—H⋯O hydrogen bonds involving nitrate anions as acceptors, generating supra­molecular chains along the diagonal of the bc plane

Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population

Nasopharyngeal carcinoma (NPC) is characterized by a high prevalence in Southern China, especially among Cantonese individuals of the Guangdong Province. Epidemiological studies have suggested that frequent exposure to high levels of nitrosamine from preserved foods such as salted fish could be a risk factor for NPC. Cytochrome P450 encompasses a family of enzymes that metabolize carcinogens and CYP2A13, a member of this family, is expressed predominantly in the respiratory tract with the highest levels in the nasal mucosa. In an effort to test whether a correlation exists between CYP2A13 genetic polymorphism and the risk of developing NPC, we sequenced all nine exons and the exon-intron junctions of the CYP2A13 gene in 45 NPC patients. We identified a total of 21 single nucleotide polymorphism (SNPs), including 7 novel SNPs. The most frequent functional variant allele was 74A-1757G-3375T-7233G with a haplotype frequency of 7.8% in the 45 NPC cases. In addition, a stop codon mutation was detected in one case. We then selected the 3 most frequent SNPs and one stop codon mutation to expand our study to a case-control analysis within the Cantonese population. A novel haplotype consisting 8 SNPs in introns, and four additional novel SNPs were identified; but no correlation between CYP2A13 genetic polymorphism and individual susceptibility to NPC was observed