Diseño de un modelo práctico para la creación de cursos virtuales de aprendizaje orientados a estudiantes que inician en la Universidad Tecnológica de Pereira caso práctico curso matemáticas

Durante el transcurso de la carrera de un estudiante se van evidenciando los diferentes problemas claves por los cuales se da el bajo rendimiento académico. Uno de los problemas más destacados es que los estudiantes no tienen buenas bases en el área de las matemáticas antes de ingresar a la universidad y mientras cursan las materias básicas desertan por no poder alcanzar los logros propuestos. Por esta razón en la Universidad Tecnológica de Pereira se inició el semestre de articulación en el que se busca subsanar estas falencias en los estudiantes para reducir la deficiencia académica. Con la implementación de este semestre de articulación se evidencio la falta de ayudas virtuales específicas para estos estudiantes que apenas inician su vida universitaria

Certificación energética de edificios sanitarios de la Gerencia de Atención Especializada de Valladolid-Este

Este proyecto tiene como finalidad última la obtención y registro de dos certificados de eficiencia energética de centros sanitarios pertenecientes a la gerencia de atención especializada Valladolid-Este. Para ello se comienza introduciendo la necesidad de la certificación energética, así como los conceptos fundamentales del proceso: demanda, consumo, emisiones, balance energético...A continuación se revisan las progresivas directivas europeas referidas a la certificación energética de edificios, además del grado de implantación de las mismas en cada uno de los países miembros de la UE. Se realiza además una exposición más detallada de la situación de la certificación energética en España, así como de su legislación y métodos de cálculo. Por ´ultimo se lleva a cabo la obtención y registro de dos certificados de eficiencia energética; el primero mediante la opción general Calener GT y el segundo mediante la opción simplificada CE3X.Departamento de Ingeniería Energética y FluidomecánicaGrado en Ingeniería Mecánic

The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells

Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive hepatic insufficiency associated with high mortality unless liver transplantation is performed. We have hypothesized that the deficiency of critical nutrients such as essential omega-3 fatty acids might play a role in the progression of liver cirrhosis. Here we evaluated by LC-MS/MS the liver content of omega-3 docosahexaenoic fatty acid (DHA) in cirrhotic patients and investigated the effect of DHA in a murine model of liver injury and in the response of hepatic stellate cells (HSCs) (the main producers of collagen in the liver) to pro-fibrogenic stimuli. We found that cirrhotic livers exhibit a marked depletion of DHA and that this alteration correlates with the progression of the disease. Administration of DHA exerts potent anti-fibrogenic effects in an acute model of liver damage. Studies with HSCs show that DHA inhibits fibrogenesis more intensely than other omega-3 fatty acids. Data from expression arrays revealed that DHA blocks TGFβ and NF-κB pathways. Mechanistically, DHA decreases late, but not early, SMAD3 nuclear accumulation and inhibits p65/RelA-S536 phosphorylation, which is required for HSC survival. Notably, DHA increases ADRP expression, leading to the formation of typical quiescence-associated perinuclear lipid droplets. In conclusion, a marked depletion of DHA is present in the liver of patients with advanced cirrhosis. DHA displays anti-fibrogenic activities on HSCs targeting NF-κB and TGFβ pathways and inducing ADPR expression and quiescence in these cells.This study was supported by European FEDER funding and grants from the Ministry of Economy (SAF2015-70971-R), Gobierno de Navarra 0011-1365-2016-000308, Fundación Echevano, Fundación Unicaja, and Fondo de Investigación Sanitaria (PI16/02081), financed by the Instituto de Salud Carlos III

Algae in acid mine drainage and relationships with pollutants in a degraded mining ecosystem

Acid mine drainage represents an extreme environment with high concentrations of potentially toxic elements and low pH values. These aquatic habitats are characterised by harsh conditions for biota, being dominated by acidophilic organisms. The study site, São Domingos mine, located in one of the largest metallogenetic provinces in the world, the Iberian Pyrite Belt, was closed without preventive measures. To identify the algae species and understand the relationships with abiotic parameters of the ecosystem, water and biological material were collected and analysed. Digital terrain models were obtained with an unmanned aerial vehicle for geomorphological and hydrologic characterisation of the mine degraded landscape. The results show two types of algal colours that seem to represent different degrees of photosynthetic activity. Optical and scanning electron microscopy revealed 14 taxa at the genus level, divided into eight classes. The genus Mougeotia is the most abundant multicellular algae. With respect to unicellular algae, diatoms are ubiquitous and abundant. Abiotic analyses expose typical features of acid mine drainage and support an inverse relationship between chemical contamination and biological diversity. Factorial correspondence analysis indicates three groups of attributes and samples by their relationship with specific toxic elements. This analysis also suggests a close association between Spirogyra and Pb, together composing a structurally simple ecosystem. The highest contamination in the river system is related to the hydrologic patterns obtained from photogrammetric products, such as the digital surface model and flow map accumulation, indicating the input of leachates from the section having the finest sulfide-rich wastes. Information about the algae community and their association with flow patterns of toxic elements is a relevant tool from a biomonitoring perspective.info:eu-repo/semantics/publishedVersio

Diseño y cálculo estructural de una nave industrial destinada a la fabricación de muelles de carga y pasarelas

Diseño y cálculo de la estructura de un edificio industrial destinado a albergar el proceso de fabricación de muelles de carga y pasarelas. Se comprueba a través de cálculos manuales y el programa CYPE 3D, que los elementos de la estructura son capaces de soportar las diversas acciones por las que se ven sometidos.<br /

México y Jalisco en la coyuntura: segundo semestre de 1997

Análisis de coyuntura sobre los principales sucesos del segundo semestre de 1997 en Jalisco, a nivel político, económico y social: la transición política y las elecciones locales de noviembre de ese año, el impacto en México de la crisis de las economías asiáticas, el tema de la inseguridad pública y la cuestión de Chiapas.ITESO, A.C

The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells

Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive hepatic insufficiency associated with high mortality unless liver transplantation is performed. We have hypothesized that the deficiency of critical nutrients such as essential omega-3 fatty acids might play a role in the progression of liver cirrhosis. Here we evaluated by LC-MS/MS the liver content of omega-3 docosahexaenoic fatty acid (DHA) in cirrhotic patients and investigated the effect of DHA in a murine model of liver injury and in the response of hepatic stellate cells (HSCs) (the main producers of collagen in the liver) to pro-fibrogenic stimuli. We found that cirrhotic livers exhibit a marked depletion of DHA and that this alteration correlates with the progression of the disease. Administration of DHA exerts potent anti-fibrogenic effects in an acute model of liver damage. Studies with HSCs show that DHA inhibits fibrogenesis more intensely than other omega-3 fatty acids. Data from expression arrays revealed that DHA blocks TGFβ and NF-κB pathways. Mechanistically, DHA decreases late, but not early, SMAD3 nuclear accumulation and inhibits p65/RelA-S536 phosphorylation, which is required for HSC survival. Notably, DHA increases ADRP expression, leading to the formation of typical quiescence-associated perinuclear lipid droplets. In conclusion, a marked depletion of DHA is present in the liver of patients with advanced cirrhosis. DHA displays anti-fibrogenic activities on HSCs targeting NF-κB and TGFβ pathways and inducing ADPR expression and quiescence in these cells

A Reduced Order Model formulation for left atrium flow: an Atrial Fibrillation case

A data-driven Reduced Order Model (ROM) based on a Proper Orthogonal Decomposition - Radial Basis Function (POD-RBF) approach is adopted in this paper for the analysis of blood flow dynamics in a patient-specific case of Atrial Fibrillation (AF). The Full Order Model (FOM) is represented by incompressible Navier-Stokes equations, discretized with a Finite Volume (FV) approach. Both the Newtonian and the Casson's constitutive laws are employed. The aim is to build a computational tool able to efficiently and accurately reconstruct the patterns of relevant hemodynamics indices related to the stasis of the blood in a physical parametrization framework including the cardiac output in the Newtonian case and also the plasma viscosity and the hematocrit in the non-Newtonian one. Many FOM-ROM comparisons are shown to analyze the performance of our approach as regards errors and computational speed-up.Comment: 21 pages, 14 figure

Acid Mine Drainage Precipitates at the Nanometric Scale – Properties and Environmental Role

The mineral-water interactions responsible for mobilization of dissolved toxic elements in mine drainage often generate colloids that commonly occur at the nanometric scale. This study presents typical properties of these materials, mostly composed by iron-rich products. The samples were obtained in a variety of contexts, representing mine waters as well as natural acid rock drainage. It concludes by noting the potential influence of the waste and/or the host rocks on the hydrogeochemistry of the systems. Further, the water properties could control the morphology and mineralogy of this very fine material, and consequently its environmental role