Populations of models, Experimental Designs and coverage of parameter space by Latin Hypercube and Orthogonal Sampling

In this paper we have used simulations to make a conjecture about the coverage of a $t$ dimensional subspace of a $d$ dimensional parameter space of size $n$ when performing $k$ trials of Latin Hypercube sampling. This takes the form $P(k,n,d,t)=1-e^{-k/n^{t-1}}$. We suggest that this coverage formula is independent of $d$ and this allows us to make connections between building Populations of Models and Experimental Designs. We also show that Orthogonal sampling is superior to Latin Hypercube sampling in terms of allowing a more uniform coverage of the $t$ dimensional subspace at the sub-block size level.Comment: 9 pages, 5 figure

The Value of the Civil Reserve Air Fleet: How Much Could the DoD Spend on Incentives?

This study evaluated the value of the Civil Reserve Air Fleet (CRAF) program to the DoD and explored the amount that could be spent to remove potential obstacles to participation with aviation insurance and lost market share. In comparing the value of the CRAF and the cost of current incentives, it was determined that up to $1.4 million could be spent on additional incentives, annually. For multiple aircraft losses and liability claims, the Air Force would need to tap into the Defense Business Operating Fund. Therefore, a sensitivity analysis was conducted and found that for low valued aircraft, such as the DC8, the cost due to loss would exceed the cost of commercial insurance at relatively low incident rates. Thus, it may be appropriate for the DoD to absorb the cost of commercial war risk insurance for certain missions, thereby eliminating the expense resulting from a large claim. The cost due to lost market share was measured by the minimum cost required to re-enter a city pair market. At highly desirable airports, this cost is approximately$51,200 per month. However, this research found no conclusive evidence that would warrant additional monetary incentives to reduce the risk of lost market share

Road traffic offending and an inner-London magistrates’ court (1913-1963)

This article examines the impact of the growing number of prosecutions for road traffic offences at Clerkenwell Court in central London. The average number of cases heard in each courtroom remained stationary and additional traffic prosecutions were accommodated by reductions in prosecutions for drunkenness or disorderly behaviour and for regulatory offences. This change in police prosecution policy impacted on the court’s proceedings and increased the court’s workload because motorists were more likely than drunks to argue their cases and to employ legal representatives. Sentencing patterns, the memoirs of magistrates and court clerks and other published documents indicate that the court staff viewed traffic offending as essentially ‘regulatory’ and distinguished it from ‘serious crime’ except when somebody was killed or a court order was ignored. The court prioritised its own resources to deal with ‘serious crime’ at the expense of traffic prosecutions. The results of this study support Howard Taylor’s thesis that resource constraints had an important influence on police prosecution policies, but show that not only police resources but also court resources and the discretionary powers of individual magistrates were important factors in prosecution patterns

Crime Legends in Old and New Media

This project explores the contemporary meanings and persistence of the crime legend. A case study approach was used: three crime legends with a considerable history of public debunking were chosen. These cases were: the market in snuff films, the theft of vital organs for black-market transplant, and the abduction of children from theme park restrooms. Current versions circulating in Internet newsgroups and via electronic mail lists were collected. Discussions in Internet newsgroups were examined and twenty regular newsgroup participants were interviewed. The public newsgroup communication environment is such that salience is established by the interlocutors themselves, rather than by the researcher, as had been the case with previous approaches of both qualitative and quantitative approaches. News reports about these legends, and fictional film and television depictions of the crimes in these legends were also sought out for content analysis. Multiple sources of data were sought in order to address the hard-to-document nature of rumors and urban legends. The news media do not appear to be a significant intentional vector of crime legends. This finding suggests that the crime legend remains a largely word-of-mouth, and now e-mail based form which travels mainly through informal, personal networks of dissemination. Styles of belief and disbelief were found to be varied and mutually dependent: the resonance of each tale involves the consideration and rejection of skepticism. Most believers engaged in conditional or instrumental forms of belief, finding them useful as truths regardless of their basis in conventional evidence. This situation suggests that rumors and legends can be sustained in the absence of fervent or strictly literal believers. This inquiry also revealed that specific legends are deployed to adapt to generalized fear, or that fear which results from a sense of ontological insecurity (Giddens, 1990). Following Giddens\u27 formulation, this insecurity is intertwined with distrust stemming from an uncertain relationship between the individual and the social protection expected in the past from both formal state activities and informal routines which were seen to provide safety in numbers. Crime legends, understood as social practices as well as texts, concentrate, individualize, and normalize public, safety threats

Joint Replenishment and Supply Chain Actions in the Retail Grocery Industry: Two Essays

This study investigated supply chain management practices in the retail grocery industry from two perspectives. First, the operational performance objectives were examined by developing and testing a periodic review, joint replenishment model and heuristic. Joint replenishment policies, designed to coordinate the ordering of multiple items, can reduce inventory costs by synchronizing transportation and replenishment decisions (Cetinkaya and Lee, 2000). A fully specified model was developed taking into account the cost disadvantage of over-declared shipments. Based on the performance of the Full model, a Truck heuristic was proposed to fill a truck with each order. By varying the model parameters, the study demonstrated the large impact transportation costs had on total inventory costs and the viability of the Truck heuristic, even for moderate differences in transportation rates. A simulation study tested violations of the demand normality assumption and found the Full model suboptimized the order interval and base stock levels under non-normal demand conditions. The result was a 2 percent cost increase over the expected costs in the Full model. The primary cost drivers were positive or negative deviations from truckload shipments and higher than expected demand during the order interval and replenishment period. The second essay examined the strategic objectives of the retail grocer using the Schumpeterian perspective to relate supply chain actions, market-based actions, and firm performance in a longitudinal study. A structured content method was used to code articles reporting on supply chain and market-based activities. The study found that higher levels of supply chain and market-based actions, a source of competitive advantage, resulted in higher sales growth. Unexpectedly, firms engaged in a broad range of supply chain activities realized a decline in sales, suggesting that a more narrow focus on specific supply chain programs provided greater financial benefits to firms in the retail grocery industry. An exploratory study using cluster analysis found grocery retailers used a variety of strategies. Larger firms were more likely to focus on market-based strategies and realized the largest sales growth. Smaller firms, on the other hand, tended to choose balanced or supply chain-focused strategies, while still realizing average sales growth

A mouse model for HIV-1 entry

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody’s ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions

Thermal Starch Properties in Corn Belt and Exotic Corn Inbred Lines and Their Crosses

More knowledge is needed about variability of starch functional traits in adapted and exotic germplasm and possible genetic effects of these traits before conducting rigorous inheritance studies and breeding programs for starch quality. We studied and compared the range of variability for starch functional traits in a set of Corn Belt inbred lines with a set of exotic inbred lines from Argentina, Uruguay, and South Africa. Reciprocal hybrids of some of the lines within each set were compared with their parents. Functional traits were examined by using differential scanning calorimetry on starch extracted from single kernels of genotypes. The set of Corn Belt lines had a wider range of values for most traits than did the set of exotic lines. For both sets of lines, the maximum value for peak height index was as high as that previously reported for the waxy endosperm mutant. Although the Corn Belt lines exhibited a wider range of values for range of retrogradation than the exotic lines, the exotic lines showed a wider range of values for percentage retrogradation. Hybrid values were not consistently higher, lower, midpoint, or similar with respect to the values of their parents. This was true regardless of germplasm type or functional trait. Reciprocal cross values showed trends suggesting reciprocal differences, although there was no trend suggesting greater effect of the female parent. These traits seem to be controlled by many modifying effects in addition to major effects. Results indicate that sufficient variability exists in Corn Belt germplasm to conduct breeding and inheritance studies effectively and that there should be potential for breeding for functional traits

Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina

The size of an organ is largely determined by the number of cells it contains, which in turn is regulated by two opposing processes, cell proliferation and cell death, however, it is generally not clear how cell proliferation and cell death are coordinated during development. Here, we characterize the zebrafish dou yan mi234 mutation that results in a dramatic reduction of retinal size and a disruption of retinal differentiation and lamination. The retinal size reduction is caused by increased retinal cell death in a non–cell-autonomous manner during early development. The phenotypic defect in dou yan mi234 arises coincident with the onset of retinal neurogenesis and differentiation. Interestingly, unlike many other small eye mutations, the mutation does not increase the level of cell death in the brain, suggesting that the brain and retina use different mechanisms to maintain cell survival. Identification and further study of the dou yan gene will enhance our understanding of the molecular mechanisms regulating retinal cellular homeostasis, i.e., the balance between cell proliferation and cell death. Developmental Dynamics 236:1295–1306, 2007. © 2007 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56024/1/21148_ftp.pd

Southeastern Association of Law Libraries Annual Meeting

The 2009 SEAALL Annual Meeting was held in Athens Georgia, April 16-18, 2009

Height, selected genetic markers and prostate cancer risk:Results from the PRACTICAL consortium

Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions. Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height 4180cm are at a 22% increased risk as compared to men with height o173cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group. Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.</p