Pathophysiology of Bradykinin-Mediated Angioedema: The Role of the Complement System

The “complement system” is one of the effector pathways of the immune system against microorganisms and tumor cells. The complement system can be activated through three major pathways: classical, lectin, and alternative. The sequential activation through the generation of complex enzymes from inactive zymogens produces a cascade in which a capable enzyme generates a large number of active downstream molecules

Short‐Term Prophylaxis in Odontostomatological, Maxillofacial and ENT Procedures in Patients with Hereditary Angioedema Due to C1‐Inhibitor Deficiency

Oestrogens, trauma, infections or stress has been described as triggers for angioedema (AE) attacks in patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE). Microtrauma can precipitate the onset of acute AE attacks, and thus, dental-oral procedures carry a high risk of triggering them and also an increased risk of death from asphyxiation due to the AE location. In the past, without proper specific treatment, the overall mortality after dental surgery in patients with C1-INH-HAE was up to 30–40%. Some dental-oral, medical and/or surgical procedures are susceptible to receive “short-term prophylaxis” (STP) in order to reduce the risk of AE. We describe the published case reports of dental-oral, maxillofacial and ear, nose and throat (ENT) procedures in patients with C1-INH-HAE. Different consensus algorithms and clinical guidelines have been published for managing dental-oral, maxillofacial and otolaryngological procedures (DOMFOPs) and will be reviewed below. Based on the clinical experience of the Department of Allergology of the University Hospital La Paz (Madrid) and the University General Hospital Nuestra Señora del Prado (Talavera de la Reina), these algorithms have been updated and modified. We advise to classify procedures according to the risk of producing AE as minor, intermediate and major risks

Evolutionary differences in the execution of Wason selection task with abstract and deontic material

En la presente investigación se estudia el razonamiento condicional de sujetos pertenecientes a los estadios de operaciones concretas y operaciones formales mediante la Tarea de Selección de Wason. La tarea consiste en presentar cuatro tarjetas y una regla que enuncia la relación existente entre los elementos que contienen. El sujeto tiene que comprobar si la regla es o no cierta levantando el menor número de tarjetas posible. Esta tarea ha sido presentada en dos versiones: una con contenido abstracto y otra con contenido deóntico facilitador. Se pretende encontrar diferencias en la ejecución debidas a las modalidades de la tarea y a las características de pensamiento de cada grupo de sujetos.In this research, we study the conditional reasoning of individuals belonging to concrete operational stages and to formal operational stages by means of Wason Selection Task. The task consists in showing four cards and a rule formulating the relationship existing among the elements they contain. The individual has to check if the rule is true or not, turning over the minimum number of cards. This task has been submitted into two versions: one with abstract content and the other with facilitator deontic content. It is intended, therefore, to find out the performance differences due to the arrangements of the task and the characteristics of thinking of each group of individuals.peerReviewe

Current and Future Asthma Treatments: Phenotypical Approach on the Path to Personalized Medicine in Asthma

Despite widely available and effective treatments, achieving asthma control is still an unmet need for many patients. One of the explanations resides perhaps in the heterogeneity of the disease. Asthma is in fact, as we understand it today, a complex syndrome made up of numerous disease variants or asthma phenotypes; when the different underlying mechanisms are identified, the more ambitious term “endotype” is used, with consequent therapeutic implications. Remarkable efforts have been made to identify the features of difficult-to-control (usually severe) asthma, which are different from those described for mild-to-moderate asthma, setting the stage for the development of new and even individualized therapies. As different drugs target different pathways, it is necessary to determine the individual profile of pathophysiological abnormalities for each patient. The most fascinating options of the new asthma treatments are the monoclonal antibodies targeted against key inflammatory cytokines, and the most proximately available treatments within the next years are discussed here. Also, current evidence and understanding of somehow older therapeutic options, such as anticholinergics, thermoplasty, or omalizumab, are reviewed from a phenotypical approach

Mobile app-control diabetes

En este proyecto se ha desarrollado una aplicación móvil desarrollada para la plataforma Android y pensada principalmente para la monitorización de las personas que padecen diabetes. En ella se informará de las actividades físicas realizadas mediante el uso de la API de Google Fit, además del tiempo de actividad, una estimación de las calorias consumidas, y una observación/consejo de tipo nutricional en función de dichas calorias. El usuario dispondrá de una sección de configuración donde podrá establecer un límite calórico, y datos de contacto que permitan realizer alertas automáticas (lamadas, sms, emails) en caso de existir peligro de hipoglucemia. En la realización del proyecto se ha llevado a cabo una fase de extracción de requisitos de la aplicación así como un diseño de misma. En la implementación se ha seguido una metodología de desarrollo SCRUM y en el interfaz se ha seguido el principio de diseño de simplicidad y funcionalidad. Por ultimo, se han realizado las unidades de tests necesarias para comprobar, mínimamente, la funcionalidad de la app

Eficacia y seguridad de la profilaxis a corto plazo con andrógenos atenuados y/o concentrado plasmático de C1 inhibidor en la relación de procedimientos odontoestomatológicos, maxilofaciales y otorrinolaringológicos en pacientes con angiodema hereditario por déficit de la proteína inhibidor de la C1 Esterasa funcionalmente activa

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 17-10-2017Esta tesis tiene embargado el acceso al texto completo hasta el 17-04-201

Motion Detection by Microcontroller for Panning Cameras

Motion detection is the first essential process in the extraction of information regarding moving objects. The approaches based on background difference are the most used with fixed cameras to perform motion detection, because of the high quality of the achieved segmentation. However, real time requirements and high costs prevent most of the algorithms proposed in literature to exploit the background difference with panning cameras in real world applications. This paper presents a new algorithm to detect moving objects within a scene acquired by panning cameras. The algorithm for motion detection is implemented on a Raspberry Pi microcontroller, which enables the design and implementation of a low-cost monitoring system.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech