Actitudes medio ambientales en los estudiantes del Máster Universitario en Formación del Profesorado de ESO y Bachillerato, Formación Profesional y Enseñanzas de Idiomas de la Universidad Complutense de Madrid.

Análisis de las actitudes medioambientales presentes en los estudiantes del Máster Universitario en Formación del Profesorado de ESO y Bachillerato,Formación Profesional y Enseñanzas de Idiomas de la Universidad Complutense de Madrid

Peripheral T-cell lymphoma: Molecular profiling recognizes subclasses and identifies prognostic markers

Peripheral T-cell lymphoma (PTCL) is a clinically aggressive disease, with a poor response to therapy and a low overall survival rate of approximately 30% after 5 years. We have analyzed a series of 105 cases with a diagnosis of PTCL using a customized NanoString platform (NanoString Technologies, Seattle, WA) that includes 208 genes associated with T-cell differentiation, oncogenes and tumor suppressor genes, deregulated pathways, and stromal cell subpopulations. A comparative analysis of the various histological types of PTCL (angioimmunoblastic T-cell lymphoma [AITL]; PTCL with T follicular helper [TFH] phenotype; PTCL not otherwise specified [NOS]) showed that specific sets of genes were associated with each of the diagnoses. These included TFH markers, cytotoxic markers, and genes whose expression was a surrogate for specific cellular subpopulations, including follicular dendritic cells, mast cells, and genes belonging to precise survival (NF-κB) and other pathways. Furthermore, the mutational profile was analyzed using a custom panel that targeted 62 genes in 76 cases distributed in AITL, PTCL-TFH, and PTCL-NOS. The main differences among the 3 nodal PTCL classes involved the RHOAG17V mutations (P < .0001), which were approximately twice as frequent in AITL (34.09%) as in PTCL-TFH (16.66%) cases but were not detected in PTCL-NOS. A multivariate analysis identified gene sets that allowed the series of cases to be stratified into different risk groups. This study supports and validates the current division of PTCL into these 3 categories, identifies sets of markers that can be used for a more precise diagnosis, and recognizes the expression of B-cell genes as an IPI-independent prognostic factor for AITL

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Persistence of chemoresistant minimal residual disease (MRD) plasma cells (PCs) is associated with inferior survival in multiple myeloma (MM). Thus, characterization of the minor MRD subclone may represent a unique model to understand chemoresistance, but to our knowledge, the phenotypic and genetic features of the MRD subclone have never been investigated. Here, we compared the antigenic profile of MRD vs diagnostic clonal PCs in 40 elderly MM patients enrolled in the GEM2010MAS65 study and showed that the MRD subclone is enriched in cells overexpressing integrins (CD11a/CD11c/CD29/CD49d/CD49e), chemokine receptors (CXCR4), and adhesion molecules (CD44/CD54). Genetic profiling of MRD vs diagnostic PCs was performed in 12 patients; 3 of them showed identical copy number alterations (CNAs), in another 3 cases, MRD clonal PCs displayed all genetic alterations detected at diagnosis plus additional CNAs that emerged at the MRD stage, whereas in the remaining 6 patients, there were CNAs present at diagnosis that were undetectable in MRD clonal PCs, but also a selected number of genetic alterations that became apparent only at the MRD stage. The MRD subclone showed significant downregulation of genes related to protein processing in endoplasmic reticulum, as well as novel deregulated genes such as ALCAM that is prognostically relevant in MM and may identify chemoresistant PCs in vitro. Altogether, our results suggest that therapy-induced clonal selection could be already present at the MRD stage, where chemoresistant PCs show a singular phenotypic signature that may result from the persistence of clones with different genetic and gene expression profiles. This trial was registered at www.clinicaltrials.gov as #NCT01237249

A randomized, double-blind study on the efficacy of oral domperidone versus placebo for reducing SARS-CoV-2 viral load in mild-to-moderate COVID-19 patients in primary health care

15 p.-3 fig.-3 tab.Introduction:The clinical effect of domperidone against COVID-19 has been investigated in a double-blind phase III clinical trial (EudraCT number 2021-001228-17). Domperidone has shown in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential immudolatory properties through the stimulation of prolactin secretion.Patients and methods:The efficacy of oral domperidone plus standard of care (SOC; n = 87) versus placebo plus SOC (n = 86) was evaluated in a 28-day randomized double-blind multicentre study in primary health care centres. A total of 173 outpatients with mild-to-moderate COVID-19 were included. Three daily doses of 10 mg (30 mg/day) of domperidone or placebo were administered for 7 days. Reduction of viral load on day 4 was the primary efficay endpoint. It was estimated in saliva samples by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), as the cycle thresholds detected ORF1ab, N Protein and S Protein genes.Results:A significant reduction in the viral load was observed (p < 0.001) from baseline to days 4, 7 and 14 of the three genes studied with non-significant differences between domperidone and placebo groups. Twenty-three patients (13.3%) experienced adverse events, 14 patients in the domperidone group (16.1%) and 9 patients in the placebo group (10.5%). No patients needed to be hospitalized.Conclusion: Results do not prove the use of domperidone as antiviral in patients with COVID-19.This research was funded by CSIC (grant no. PIE 201980E024) and by the European Commission: NextGeneration EU (Regulation EU 2020/2094) through CSIC’s Global Health Platform (PTI Salud Global). The study sponsor was Agencia Estatal Consejo Superior de Investigaciones Científicas, M.P. (CSIC), Madrid, Spain. The sponsor was involved in the design, data interpretation, manuscript review and the decision to submit the article for publication.Peer reviewe

REGULACIÓN LEGAL DEL ACOSO LABORAL (I): JURISDICCIÓN SOCIAL

Hasta hace unos años, el centro de trabajo se consideraba un lugar donde los empleados podían sentirse a salvo. Por desgracia, la situación ha cambiado. De hecho, cada día es más frecuente la violencia en el entorno laboral. Podemos encontrar dos categorías diferentes dentro de la violencia en el trabajo: la primera estaría formada por las acciones violentas de un no-empleado a un empleado. Y, la segunda por la violencia ejercida por empleados contra otros empleados (1). En los años 80,..

COMUNIDAD DELITOS Y PRUEBAS EN GOOGLE+

Ahora te puedes unir a la Comunidad "Delitos y Pruebas" en Google+ para intercambiar conocimientos de Criminología y Seguridad con otros usuarios. Te esperamos

XV SESIÓN DEL SEMINARIO INTERNACIONAL PERMANENTE DE DERECHO PENAL Y CRIMINOLOGÍA DE LA UNED: "EL DERECHO PENAL ANTE LA CORRUPCIÓN"

El pasado miércoles, 20 de diciembre, se celebró la XV sesión del Seminario Internacional Permanente de Derecho Penal y Criminología (SIP) de la UNED. El tema central fue "El Derecho Penal ante la corrupción", y contó con dos conferencias: por un lado, Manuel Jaén Vallejo nos habló de las "Últimas reformas penales en materia de corrupción"; y, por otro lado, la ponencia de Nicolás García Rivas se centró en "La financiación ilegal de los partidos políticos". En este enlace tenéis disponible..

GRABACIÓN DEL SEMINARIO SOBRE "TENDENCIAS ACTUALES EN POLÍTICA CRIMINAL"

El pasado 21 de febrero tuvo lugar la XV sesión del Seminario Internacional Permanente de Derecho penal y Criminología, en el Salón de Actos de la Facultad de Ciencias Políticas de la UNED. En esta ocasión, el tema central del seminario fueron las "Tendencias actuales en Política Criminal". Tenéis la grabación en el siguiente enlace de CanalUNED: https://canal.uned.es/series/5a6f70abb1111f53648b456

LIBROS DE GALERAS

Este fin de semana es el último para disfrutar de la exposición "Hombres de la mar, barcos de leyenda" en el Museo Naval de Madrid, cuyo Comisario es el escritor Arturo Pérez Reverte. Como curiosidad, la exposición cuenta con dos Libros de Galeras, donde se registraban los datos de los presos que cumplían este tipo de pena. Destaca la minuciosidad de su elaboración y la precisión de los datos (altura, color de pelo, color de ojos...). El tiempo máximo de la pena de galeras era de 10 años, ..