A spin- and angle-resolving photoelectron spectrometer

A new type of hemispherical electron energy analyzer that permits angle and spin resolved photoelectron spectroscopy has been developed. The analyzer permits standard angle resolved spectra to be recorded with a two-dimensional detector in parallel with spin detection using a mini-Mott polarimeter. General design considerations as well as technical solutions are discussed and test results from the Au(111) surface state are presented

Island properties dominate species traits in determining plant colonizations in an archipelago system

The extrinsic determinants hypothesis emphasizes the essential role of environmental heterogeneity in species' colonization. Consequently, high resident species diversity can increase community susceptibility to colonizations because good habitats may support more species that are functionally similar to colonizers. On the other hand, colonization success is also likely to depend on species traits. We tested the relative importance of environmental characteristics and species traits in determining colonization success using census data of 587 vascular plant species collected about 70 yr apart from 471 islands in the archipelago of SW Finland. More specifically, we explored potential new colonization as a function of island properties (e.g. location, area, habitat diversity, number of resident species per unit area), species traits (e.g. plant height, life-form, dispersal vector, Ellenberg indicator values, association with human impact), and species' historical distributions (number of inhabited islands, nearest occurrence). Island properties and species' historical distributions were more effective than plant traits in explaining colonization outcomes. Contrary to the extrinsic determinants hypothesis, colonization success was neither associated with resident species diversity nor habitat diversity per se, although colonization was lowest on sparsely vegetated islands. Our findings lead us to propose that while plant traits related to dispersal and establishment may enhance colonization, predictions of plant colonizations primarily require understanding of habitat properties and species' historical distributions.Peer reviewe

Estimation of Steam Turbine Shafts Fatigue Damage Caused by Torsional Vibrations

В Україні 74 енергоблоки потужністю 150-800 МВт теплових електростанцій із 102 перебувають на межі перевищення паркового ресурсу (220 тис. Годин). З них 17 енергоблоків наближаються до кінця ресурсу парку, а 11 енергоблоків досягли передбачуваного ресурсу (100 тис. Годин). Статистика аварій на електростанціях у різних країнах показує, що більшість з них спричинені тривалим накопиченням збитків від втоми. Серед основних причин пошкодження втоми - пульсація високотемпературних потоків пари в циліндрах турбіни, поперечні та крутильні коливання валів при тривалій експлуатації тощо. Це обумовлює розробку обчислювальних та експериментальних методів визначення втомних пошкоджень вали турбінних установок при динамічних навантаженнях. Оцінка втомних пошкоджень вала парової турбіни К-200-130 базується на 3D-моделі кінцевих елементів. Розрахунки враховують експериментально визначені втомні властивості роторної сталі. Розраховано втомну пошкодження в результаті крутильних коливань валу турбіни, спричинених аномальною роботою турбінного генератора. Зони концентрації напружень в обертових елементах парової турбіни типу К-200-130 встановлені для різних режимів роботи. Запропоновано процедуру прогнозування впливу втоми від пошкоджень на розрахунковий ресурс турбінного агрегату.In Ukraine, 74 power units with a capacity of 150-800 MW of thermal power plants out of 102 are on the verge of exceeding the park resource (220 thousand hours). Of these, 17 power units are close to the end the park resource, and 11 units have reached their estimated resource (100 thousand hours). Statistics of power plants accidents in different countries indicates that most of them are caused by the long term accumulation of fatigue damage. Among the main causes of fatigue damage are the pulsating of high-temperature steam flows in the turbine cylinders, transverse and torsional vibrations of shafts during long-term operation etc. This causes the development of computational and experimental methods for the determination of fatigue damage of turbine units’ shafts under dynamic loads. The evaluation of fatigue damage of steam turbine K-200-130 shaft is based on the 3D finite element model. The calculations take into account experimentally determined fatigue properties of rotor steel. The fatigue damage as a result of torsional vibrations of turbine shaft caused by the abnormal operation of turbine generator is calculated. Zones of stress concentration in the rotating elements of the steam turbine type K-200-130 are established for various operating modes. The procedure to predict the effect of fatigue damage on the estimated resource of turbine unit is proposed.В Украине 74 энергоблока мощностью 150-800 МВт тепловых электростанций из 102 находятся на грани превышения ресурса парка (220 тыс. Часов). Из них 17 энергоблоков близки к исчерпанию ресурса парка, а 11 энергоблоков вышли на расчетный ресурс (100 тыс. Часов). Статистика аварий на электростанциях в разных странах показывает, что большинство из них вызвано длительным накоплением усталостных повреждений. Среди основных причин усталостных повреждений - пульсации высокотемпературных потоков пара в цилиндрах турбины, поперечные и крутильные колебания валов при длительной эксплуатации и т. Д. Это вызывает развитие расчетных и экспериментальных методов определения усталостных повреждений. валы турбоагрегатов при динамических нагрузках. Оценка усталостных повреждений вала паровой турбины К-200-130 проводится на основе трехмерной конечно-элементной модели. В расчетах учтены экспериментально определенные усталостные свойства роторной стали. Рассчитано усталостное повреждение в результате крутильных колебаний вала турбины, вызванных ненормальной работой турбогенератора. Установлены зоны концентрации напряжений во вращающихся элементах паровой турбины типа К-200-130 для различных режимов работы. Предложена методика прогнозирования влияния усталостных повреждений на расчетный ресурс турбоагрегата

HLA-A Confers an HLA-DRB1 Independent Influence on the Risk of Multiple Sclerosis

A recent high-density linkage screen confirmed that the HLA complex contains the strongest genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium analysis using 650 single nucleotide polymorphisms (SNP) markers of the HLA complex mapped the entire genetic effect to the HLA-DR-DQ subregion, reflected by the well-established risk haplotype HLA-DRB1*15,DQB1*06. Contrary to this, in a cohort of 1,084 MS patients and 1,347 controls, we show that the HLA-A gene confers an HLA-DRB1 independent influence on the risk of MS (P = 8.4×10−10). This supports the opposing view, that genes in the HLA class I region indeed exert an additional influence on the risk of MS, and confirms that the class I allele HLA-A*02 is negatively associated with the risk of MS (OR = 0.63, P = 7×10−12) not explained by linkage disequilibrium with class II. The combination of HLA-A and HLA-DRB1 alleles, as represented by HLA-A*02 and HLA-DRB1*15, was found to influence the risk of MS 23-fold. These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS

On the relations between historical epistemology and students’ conceptual developments in mathematics

There is an ongoing discussion within the research field of mathematics education regarding the utilization of the history of mathematics within mathematics education. In this paper we consider problems that may emerge when the historical epistemology of mathematics is paralleled to students’ conceptual developments in mathematics. We problematize this attempt to link the two fields on the basis of Grattan-Guinness’ distinction between “history” and “heritage”. We argue that when parallelism claims are made, history and heritage are often mixed up, which is problematic since historical mathematical definitions must be interpreted in its proper historical context and conceptual framework. Furthermore, we argue that cultural and local ideas vary at different time periods, influencing conceptual developments in different directions regardless of whether historical or individual developments are considered, and thus it may be problematic to uncritically assume a platonic perspective. Also, we have to take into consideration that an average student of today and great mathematicians of the past are at different cognitive levels

Roadmap for a precision-medicine initiative in the Nordic region

The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.Non peer reviewe

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

A wealth of biospecimen samples are stored in modern globally distributed biobanks. Biomedical researchers worldwide need to be able to combine the available resources to improve the power of large-scale studies. A prerequisite for this effort is to be able to search and access phenotypic, clinical and other information about samples that are currently stored at biobanks in an integrated manner. However, privacy issues together with heterogeneous information systems and the lack of agreed-upon vocabularies have made specimen searching across multiple biobanks extremely challenging. We describe three case studies where we have linked samples and sample descriptions in order to facilitate global searching of available samples for research. The use cases include the ENGAGE (European Network for Genetic and Genomic Epidemiology) consortium comprising at least 39 cohorts, the SUMMIT (surrogate markers for micro- and macro-vascular hard endpoints for innovative diabetes tools) consortium and a pilot for data integration between a Swedish clinical health registry and a biobank. We used the Sample avAILability (SAIL) method for data linking: first, created harmonised variables and then annotated and made searchable information on the number of specimens available in individual biobanks for various phenotypic categories. By operating on this categorised availability data we sidestep many obstacles related to privacy that arise when handling real values and show that harmonised and annotated records about data availability across disparate biomedical archives provide a key methodological advance in pre-analysis exchange of information between biobanks, that is, during the project planning phase

Variation in the Structure of Bird Nests between Northern Manitoba and Southeastern Ontario

Traits that converge in appearance under similar environmental conditions among phylogenetically independent lineages are thought to represent adaptations to local environments. We tested for convergence in nest morphology and composition of birds breeding in two ecologically different locations in Canada: Churchill in northern Manitoba and Elgin in southeastern Ontario. We examined nests from four families of passerine birds (Turdidae: Turdus, Parulidae: Dendroica, Emberizidae: Passerculus and Fringillidae: Carduelis) where closely related populations or species breed in both locations. Nests of American Robins, Yellow Warblers, and Carduelis finches had heavier nest masses, and tended to have thicker nest-walls, in northern Manitoba compared with conspecifics or congenerics breeding in southeastern Ontario. Together, all species showed evidence for wider internal and external nest-cup diameters in northern Manitoba, while individual species showed varying patterns for internal nest-cup and external nest depths. American Robins, Yellow Warblers, and Carduelis finches in northern Manitoba achieved heavier nest masses in different ways. American Robins increased all materials in similar proportions, and Yellow Warblers and Common Redpolls used greater amounts of select materials. While changes in nest composition vary uniquely for each species, the pattern of larger nests in northern Manitoba compared to southeastern Ontario in three of our four phylogenetically-independent comparisons suggests that birds are adapting to similar selective pressures between locations