Measurement of uncertainty costs with dynamic traffic simulations

Non-recurrent congestion in transportation networks occurs as a consequence of stochastic factors affecting demand and supply. Intelligent Transportation Systems such as Advanced Traveler Information Systems (ATIS) and Advanced Traffic Management Systems (ATMS) are designed in order to reduce the impacts of non-recurrent congestion by providing information to a fraction of users or by controlling the variability of traffic flows. For these reasons, the design of ATIS and ATMS requires reliable forecast of non-recurrent congestion. This paper proposes a new method to measure the impacts of non-recurrent congestion on travel costs by taking risk aversion into account. The traffic model is based on the dynamic traffic simulations model METROPOLIS. Incidents are generated randomly by reducing the capacity of the network. Users can instantaneously adapt to the unexpected travel conditions or can also change their behavior via a day-to-day adjustment process. Comparisons with incident-free simulations provide a benchmark for potential travel time savings that can be brought in by a state-of-the-art information system. We measure the impact of variable travel conditions by describing the willingness to pay to avoid risky or unreliable journeys. Indeed, for risk averse drivers, any uncertainty corresponds to a utility loss. This utility loss is computed for several levels of network disruption. The main results of the paper is that the utility loss due to uncertainty is of the same order of magnitude as the total travel costs.

Developments of the pinned photodiode terahertz rectifier

This paper presents we presents a development of the structure of the pinned photodiode terahertz rectifier, in which the metal whisker of the antenna is separated from the semiconductor by a silane oxide layer, in order to reduce the surface defectiveness. The rectifies is the basic component of an image detection system based on the structure of actual CMOS image detectors. The structure combines a nano-antenna, fabricated on the top of a standard image sensor, the rectifier, and the readout electronics. The rectifier device proposed has vertical extension of some tenths of nanometers, can be created at the foot of the nano-whisker at the end of the terahertz antenna, above the storage well

Effect of Static Disorder in an Electron Fabry-Perot Interferometer with Two Quantum Scattering Centers

In a recent paper -- F. Ciccarello \emph{et al.}, New J. Phys. \textbf{8}, 214 (2006) -- we have demonstrated that the electron transmission properties of a one-dimensional (1D) wire with two identical embedded spin-1/2 impurities can be significantly affected by entanglement between the spins of the scattering centers. Such effect is of particular interest in the control of transmission of quantum information in nanostructures and can be used as a detection scheme of maximally entangled states of two localized spins. In this letter, we relax the constraint that the two magnetic impurities are equal and investigate how the main results presented in the above paper are affected by a static disorder in the exchange coupling constants of the impurities. Good robustness against deviation from impurity symmetry is found for both the entanglement dependent transmission and the maximally entangled states generation scheme.Comment: 4 pages, 5 figure

Quantum Error Correction in Spatially Correlated Quantum Noise

We consider quantum error correction of quantum-noise that is created by a local interaction of qubits with a common bosonic bath. The possible exchange of bath bosons between qubits gives rise to spatial and temporal correlations in the noise. We find that these kind of noise correlations have a strong negative impact on quantum error correction.Comment: 4 pages, 1 figure, final version with minor correction

Resonance enhancement of particle production during reheating

We found a consistent equation of reheating after inflation, which shows that for small quantum fluctuations the frequencies of resonance are slighted different from the standard ones. Quantum interference is taken into account and we found that at large fluctuations the process mimics very well the usual parametric resonance but proceed in a different dynamical way. The analysis is made in a toy quantum mechanical model and we discuss further its extension to quantum field theory.Comment: 4 pages, 4 figures(eps), using RevTe

Observable geometric phase induced by a cyclically evolving dissipative process

In a prevous paper (Phys. Rev. Lett. 96, 150403 (2006)) we have proposed a new way to generate an observable geometric phase on a quantum system by means of a completely incoherent phenomenon. The basic idea was to force the ground state of the system to evolve ciclically by "adiabatically" manipulating the environment with which it interacts. The specific scheme we have previously analyzed, consisting of a multilevel atom interacting with a broad-band squeezed vacuum bosonic bath whose squeezing parameters are smoothly changed in time along a closed loop, is here solved in a more direct way. This new solution emphasizes how the geometric phase on the ground state of the system is indeed due to a purely incoherent dynamicsComment: 6 pages, 1 figur

Urban Cholera transmission hotspots and their implications for Reactive Vaccination: evidence from Bissau city, Guinea Bissau

Use of cholera vaccines in response to epidemics (reactive vaccination) may provide an effective supplement to traditional control measures. In Haiti, reactive vaccination was considered but, until recently, rejected in part due to limited global supply of vaccine. Using Bissau City, Guinea-Bissau as a case study, we explore neighborhood-level transmission dynamics to understand if, with limited vaccine and likely delays, reactive vaccination can significantly change the course of a cholera epidemic

Statistical ensemble of gene regulatory networks of macrophage differentiation

Background: Macrophages cover a major role in the immune system, being the most plastic cell yielding several key immune functions. Methods: Here we derived a minimalistic gene regulatory network model for the differentiation of macrophages into the two phenotypes M1 (pro-) and M2 (anti-inflammatory). Results: To test the model, we simulated a large number of such networks as in a statistical ensemble. In other words, to enable the inter-cellular crosstalk required to obtain an immune activation in which the macrophage plays its role, the simulated networks are not taken in isolation but combined with other cellular agents, thus setting up a discrete minimalistic model of the immune system at the microscopic/intracellular (i.e., genetic regulation) and mesoscopic/intercellular scale. Conclusions: We show that within the mesoscopic level description of cellular interaction and cooperation, the gene regulatory logic is coherent and contributes to the overall dynamics of the ensembles that shows, statistically, the expected behaviour

REST APIs: A large-scale analysis of compliance with principles and best practices

Quickly and dominantly, REST APIs have spread over the Web and percolated into modern software development practice, especially in the Mobile Internet where they conveniently enable offloading data and computations onto cloud services. We analyze more than 78GB of HTTP traffic collected by Italy’s biggest Mobile Internet provider over one full day and study how big the trend is in practice, how it changed the traffic that is generated by applications, and how REST APIs are implemented in practice. The analysis provides insight into the compliance of state-of-the-art APIs with theoretical Web engineering principles and guidelines, knowledge that affects how applications should be developed to be scalable and robust. The perspective is that of the Mobile Internet

Therapeutic approach in glioblastoma multiforme with primitive neuroectodermal tumor components: case report and review of the literature

Glioblastoma multiforme (GBM) is the most common and aggressive malignant glioma that is treated with first-line therapy, using surgical resection followed by local radiotherapy and concomitant/adjuvant temozolomide (TMZ) treatment. GBM is characterised by a high local recurrence rate and a low response to therapy. Primitive neuroectodermal tumour (PNET) of the brain revealed a low local recurrence rate; however, it also exhibited a high risk of cerebrospinal fluid (CSF) dissemination. PNET is treated with surgery followed by craniospinal irradiation (CSI) and platinum-based chemotherapy in order to prevent CSF dissemination. GBM with PNET-like components (GBM/PNET) is an emerging variant of GBM, characterised by a PNET-like clinical behaviour with an increased risk of CSF dissemination; it also may benefit from platinum-based chemotherapy upfront or following failure of GBM therapy. The results presented regarding the management of GBM/PNET are based on case reports or case series, so a standard therapeutic approach for GBM/PNET is not defined, constituing a challenging diagnostic and therapeutic dilemma. In this report, a case of a recurrent GBM/PNET treated with surgical resection and radiochemotherapy as Stupp protocol, and successive platinum-based chemotherapy due to the development of leptomeningeal dissemintation and an extracranial metastasis, is discussed. A review of the main papers regarding this rare GBM variant and its therapeutic approach are also reported. In conclusion, GBM/PNET should be treated with a multimodal approach including surgery, chemoradiotherapy, and/or the early introduction of CSI and platinum-based chemotherapy upfront or at recurrence