12 research outputs found
Microwave Assisted Synthesis of Py-Im Polyamides
Get PDFMicrowave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps
Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras
No full textAn oxidative enol ether rearrangement was the key methodology in the construction of steroid-spiroketal-RGD peptides. Biological studies demonstrated potent integrin CD11b/CD18 antagonistic effects. © 2009 American Chemical Society
Benzotriazole-Assisted Solid-Phase Assembly of Leu-Enkephalin, Amyloid β segment 34−42, and other “Difficult” Peptide Sequences
No full text4-Methoxybenzyloxymethyl Group, a Racemization-Resistant Protecting Group for Cysteine in Fmoc Solid Phase Peptide Synthesis
No full textDirect Solid-Phase Synthesis of the β-Amyloid (1−42) Peptide Using Controlled Microwave Heating
No full textAcylation of Glucagon-Like Peptide-2: Interaction with Lipid Membranes and In Vitro Intestinal Permeability
No full textEfficient Microwave-Assisted One Shot Synthesis of Peptaibols Using Inexpensive Coupling Reagents
No full textMechanistic Studies of the Triggered Release of Liposomal Contents by Matrix Metalloproteinase-9
No full textSolid-Phase Synthesis of Difficult Peptide Sequences at Elevated Temperatures: A Critical Comparison of Microwave and Conventional Heating Technologies
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