X-ray rocking curve study of Si-implanted GaAs, Si, and Ge

Crystalline properties of Si-implanted GaAs, Si, and Ge have been studied by Bragg case double-crystal x-ray diffraction. Sharp qualitative and quantitative differences were found between the damage in GaAs on one hand and Si and Ge on the other. In Si and Ge the number of defects and the strain increase linearly with dose up to the amorphous threshold. In GaAs the increase in these quantities is neither linear nor monotonic with dose. At a moderate damage level the GaAs crystal undergoes a transition from elastic to plastic behavior. This transition is accompanied by the creation of extended defects, which are not detected in Si or Ge

Potential sinks for geologic storage of carbon dioxide generated by power plants in North and South Carolina

Duke Energy Progress Energy Santee Cooper Power SCANA CorporationBureau of Economic Geolog

First Measurements with NeXtRAD, a Polarimetric X/L Band Radar Network

NeXtRAD is a fully polarimetric, X/L Band radar network. It is a development of the older NetRAD system and builds on the experience gained with extensive deployments of NetRAD for sea clutter and target measurements. In this paper we will report on the first measurements with NeXtRAD, looking primarily at sea clutter and some targets, as well as early attempts at calibration using corner reflectors, and an assessment of the polarimetric response of the system. We also highlight innovations allowing for efficient data manipulation post measurement campaigns, as well as the plans for the coming years with this system

EXAMINATION OF IRRADIATED EXPERIMENTAL NRU FUEL RODS. Final Report on Program 6.1.25

Examination of flat, natural uranium plates mechnnically clad with aluminum sheaths revealed a tendency for thermal contact between clad and core to diminish as a result of elongation and roughening of the uranium. The assemblies containing beta-quenched uranium showed less damage than those in which material rolled in the high alpha range was used. A clad rod having square cross section was found to have failed by typical internal aqueous attack of the core material. Cause of initial perforation cannot be assigned with certainty. (auth

Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds

Animals used in sport should be treated as required to ensure animal welfare but any such use of medication should also be controlled to ensure integrity. Pharmacokinetic studies on groups of six greyhounds were performed to measure plasma and urine levels of carprofen and firocoxib to inform medication control advice. Using the standard methodology for medication control the Irrelevant Plasma Concentration was determined as 20 ng/mL and 2 ng/mL for carprofen and firocoxib respectively. The Irrelevant Urine Concentration was also determined as 0.3 ng/ml and 2 ng/mL for carprofen and firocoxib respectively. These Irrelevant Plasma and Urine Concentrations will allo

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling

Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition

A field-deployed 810 GHz receiver incorporating a superconducting mixer developed for Herschel space telescope and a SiGe low noise amplifier

We have constructed an 810 GHz receiver system incorporating a HIFI Band-3 superconductor-insulator-superconductor (SIS) mixer developed for Herschel space observatory and a wide-band SiGe low noise amplifier (LNA) designed at Caltech. The instrument is currently installed at the RLT telescope (elevation 5500 m) in northern Chile. Hot/cold (280K/72K) load measurements performed at the telescope yield noise temperatures of 225 K (Y-factor = 1.7) including receiver optics. First-light observations indicate that the receiver is highly sensitive and functions stably. We present details of the receiver system, its performance at the telescope, and first-light observations with a Herschel mixer