Pharmacological action of lithium in the pathogenesis of psoriasis

The influence of lithium on psoriasis has been demonstrated by different studies. Lithium can induce a new onset or exacerbate pre-existing psoriasis. Different mechanisms are implicated in the pharmacological mode of action of lithium in relation to the onset of psoriasis. On the molecular level, it is well established that cAMP plays a key role in the pathogenesis of lithium-induced psoriasis. Lithium may also affect the protein kinase C-inositol-biphosphate pathway by an inhibition of inositol-1-biphosphate, resulting in the alteration of cellular transduction signals. On the cellular level, lithium has a mitogen effect and acts by blocking cellular differentiation. It also exerts a chemotactic action on neutrophil polymorphonuclear cells.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Dermatologie et psychotropes

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Une excroissance bizarre de l'ombilic chez un enfant de un mois

We report the case of an umbilical polyp, derived from omphalo mesenteric remnants in an one-month-old female child. This rare abnormality results from a closure defect of the vitelline duct. The vitelline duct normally closes between the 5th and the 7th weeks of intra embryonic development but can lead to several pathologies in case of closure defects, giving rise to abdominal (Meckel diverticulum, vitteline cyst) or ombilical symptoms (umbilical fistula, umbilical sinus and umbilical polyp). These desorders have a 2% incidence, and may induce clinical symptoms of varied gravity ranging from clinical silence to acute abdomen. We seized the opportunity of this rare clinical observation to review the nosology of vitellin duct defects at the light of embryologic data.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Eosinophilic pustular folliculitis associated with hodgkin's disease

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fulminant group A streptococcal necrotizing fasciitis of the head and neck region

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Mid-portion agenesis of corpus callosum in a presumed Baller-Gerold syndrome.

We report an association of trigonocephaly and thumb hypoplasia in a 6.5-year-old boy, diagnosed as Baller-Gerold syndrome. In addition to craniosynostosis and radial limb defect, which are constant in this syndrome, our patient presents two unusual features: the first is an epidermal nevus and the second is an agenesis of the middle portion of corpus callosum. This unique type of callosal agenesis in the context of a polymalformative disorder supports the hypothesis that partial agenesis of corpus callosum may be due to an event occurring before the 12th week gestation with continued development of the midline structures.Case ReportsJournal Articleinfo:eu-repo/semantics/publishe

Hysteresis identification using nonlinear state-space models

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an assumption may be a hard requirement to handle in real applications, since hysteresis is a highly individualistic nonlinear behaviour. The present paper adopts a black-box approach based on nonlinear state-space models to identify hysteresis dynamics. This approach is shown to provide a general framework to hysteresis identification, featuring flexibility and parsimony of representation. Nonlinear model terms are constructed as a multivariate polynomial in the state variables, and parameter estimation is performed by minimising weighted least-squares cost functions. Technical issues, including the selection of the model order and the polynomial degree, are discussed, and model validation is achieved in both broadband and sine conditions. The study is carried out numerically by exploiting synthetic data generated via the Bouc-Wen equations

Nonlinear System Identification: An Overview of Common Approaches

International audienceNonlinear mathematical models are essential tools in various engineering and scientific domains, where more and more data are recorded by electronic devices. How to build nonlinear mathematical models essentially based on experimental data is the topic of this entry. Due to the large extent of the topic, this entry provides only a rough overview of some well-known results, from gray-box to black-box system identification